Xylose as a carrier for boron containing compounds.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other tumor cell lines.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinska grundvetenskaper
Originalspråkengelska
Sidor (från-till)2451-2454
TidskriftBioorganic & Medicinal Chemistry Letters
Volym18
Utgivningsnummer7
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa