Surface Guided Helical Tomotherapy for Total Marrow Irradiation

Aktivitet: Examination och handledarskapHandledning av masterstudenter


Background: Total marrow irradiation (TMI) is a helical tomotheraphy treatment used as conditioning regimen for leukemia patients prior to stem cell transplantation. A margin is applied to the clinical target volume (CTV) to ensure adequate dose coverage, i.e. planned target volume (PTV) margin. By applying as small margin as possible the dose to organs at risk (OAR) is minimized. The PTV margin depends on the positioning deviation of the CTV. During patient positioning on the couch prior to irradiation an optical surface scanning system (OSS) can be used. By projecting visual light onto the patient surface and detecting
the reflective light, the position of the patient ́s live surface can be calculated. The live surface is compared to a reference surface, i.e. the planned position, and any deviations are corrected for prior to treatment.
This application is called surface guided radiotherapy (SGRT).
Purpose: To evaluate if the dose to OARs for patients undergoing TMI on a Tomotherapy unit can be reduced, by applying smaller treatment margins due to improved patient positioning using surface guided radiotherapy.
Period2021 sep. 152022 jan. 15
Examinerad/handledd personHedda Enocson
Examination/handledning vid

Ämnesklassifikation (UKÄ)

  • Naturvetenskap