Brain Repair and Imaging in Neural Systems (BRAINS)

Forskningsoutput

Forskningsoutput per år 1997 2000 2005 2007 2008 2009 2010 2012 2013 2023

• 157 Artikel i vetenskaplig tidskrift
• 11 Översiktsartikel
• 11 Doktorsavhandling (sammanläggning)
• 7 Publicerat konferensabstract
• 13 Mer
  • 6 Debate/Note/Editorial
  • 4 Letter
  • 2 Kapitel samlingsverk
  • 1 Konferenspaper i proceeding

Forskningsoutput per år

Forskningsoutput per år

Sökresultat

• 2023

  Cell-specific switch for epileptiform activity: critical role of interneurons in the mouse subicular network

  Wickham, J., Ledri, M., Andersson, M. & Kokaia, M., 2023 jan. 5, (E-pub ahead of print) I: Cerebral Cortex. s. 1-13 bhac493.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Interneurons 100%
  • Parvalbumins 86%
  • Light 38%
  • 4-Aminopyridine 34%
  • Neurons 24%

• Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

  Ahl, M., Taylor, M. K., Avdic, U., Lundin, A., Andersson, M., Amandusson, Å., Kumlien, E., Compagno Strandberg, M. & Ekdahl, C. T., 2023 mars, I: Heliyon. 9, 3, e13938.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Seizures 100%
  • Interleukin-6 29%
  • Immunologic Factors 27%
  • Frontal Lobe Epilepsy 19%
  • Temporal Lobe Epilepsy 15%

• Reduced epilepsy development in synapsin 2 knockout mice with autistic behavior following early systemic treatment with interleukin-6 receptor antibody

  Bäckström, F., Ahl, M., Wickham, J. & Ekdahl, C. T., 2023 feb. 26, (E-pub ahead of print) I: Epilepsy Research. 191, s. 1-12 107114.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synapsins 100%
  • Interleukin-6 Receptors 92%
  • Knockout Mice 64%
  • Epilepsy 59%
  • Seizures 47%
• 2022

  A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells

  Moriarty, N., Gantner, C. W., Hunt, C. P. J., Ermine, C. M., Frausin, S., Viventi, S., Ovchinnikov, D. A., Kirik, D., Parish, C. L. & Thompson, L. H., 2022 mars 3, I: Cell Stem Cell. 29, 3, s. 434-448.e5

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Pluripotent Stem Cells 100%
  • Mesencephalon 88%
  • Cell- and Tissue-Based Therapy 81%
  • Genetic Therapy 79%
  • Dopamine 72%

• Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks

  Marciano, S., Ionescu, T. M., Saw, R. S., Cheong, R. Y., Kirik, D., Maurer, A., Pichler, B. J. & Herfert, K., 2022 okt. 4, I: Proceedings of the National Academy of Sciences of the United States of America. 119, 40, e2122552119.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Neuroimaging 79%
  • Brain 42%
  • Genes 35%
  • Gene Editing 30%

• Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients

  Hellem, M. N. N., Cheong, R. Y., Tonetto, S., Vinther-Jensen, T., Hendel, R. K., Larsen, I. U., Nielsen, T. T., Hjermind, L. E., Vogel, A., Budtz-Jørgensen, E., Petersén, Å. & Nielsen, J. E., 2022 juni, I: Parkinsonism and Related Disorders. 99, s. 23-29 7 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Huntington Disease 100%
  • Oxytocin 98%
  • Cerebrospinal Fluid 78%
  • Cognitive Dysfunction 73%
  • Cognition 42%

• High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping

  Frantz, D., Karamahmutoglu, T., Schaser, A. J., Kirik, D. & Berrocal, E., 2022 sep. 1, I: Biomedical Optics Express. 13, 9, s. 4907-4925 19 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Lighting 100%
  • Microscopy 75%
  • illumination 68%
  • microscopy 62%
  • Light 49%

• Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats

  Tugba, E. K., Medine, G. I. O., Ozlem, A., Deniz, K. & Filiz, O. Y., 2022, I: Pharmacology Biochemistry and Behavior. 213, 173317.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Absence Epilepsy 100%
  • Serotonin 78%
  • Synaptic Transmission 66%
  • Seizures 54%
  • Dopamine 22%
• 2021

  Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease

  Huynh, B., Fu, Y., Kirik, D., Shine, J. M. & Halliday, G. M., 2021, I: Movement Disorders. 36, 9, s. 2085-2093

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Locus Coeruleus 100%
  • Substantia Nigra 89%
  • Prosencephalon 89%
  • Parkinson Disease 69%
  • Adrenergic Neurons 54%

• DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease

  Arkan, S., Ljungberg, M., Kirik, D. & Hansen, C., 2021 okt., I: Neurobiology of Disease. 158, 105477.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleinopathies 100%
  • Pars Compacta 69%
  • Parkinson Disease 59%
  • Animal Models 51%
  • Cell Death 40%

• Early white matter pathology in the fornix of the limbic system in Huntington disease

  Gabery, S., Kwa, J. E., Cheong, R. Y., Baldo, B., Ferrari Bardile, C., Tan, B., McLean, C., Georgiou-Karistianis, N., Poudel, G. R., Halliday, G., Pouladi, M. A. & Petersén, Å., 2021, I: Acta Neuropathologica. 142, 5, s. 791-806

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Limbic System 100%
  • Huntington Disease 87%
  • White Matter 71%
  • Pathology 49%
  • Oligodendroglia 23%

• Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model

  Cheong, R. Y., Baldo, B., Sajjad, M. U., Kirik, D. & Petersén, Å., 2021 juni 1, I: Neuropathology and Applied Neurobiology. 47, 4, s. 564-578 15 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Huntington Disease 100%
  • Body Weight Changes 54%
  • Corpus Striatum 43%
  • Central Nervous System 33%
  • Adenosine A2A Receptors 31%

• Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome

  Petty, A., Cui, X., Ali, A., Du, Z., Srivastav, S., Kesby, J. P., Kirik, D., Howes, O. & Eyles, D., 2021, I: Scientific Reports. 11, 1, 4294.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Schizophrenia 100%
  • Animal Models 88%
  • Phenotype 73%
  • Dopamine 64%
  • Animals 61%

• Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease

  Marmion, D. J., Rutkowski, A. A., Chatterjee, D., Hiller, B. M., Werner, M. H., Bezard, E., Kirik, D., McCown, T., Gray, S. J. & Kordower, J. H., 2021, I: Neurobiology of Disease. 148, 105184.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Multiple System Atrophy 100%
  • alpha-Synuclein 72%
  • Primates 70%
  • Rodentia 62%
  • Inclusion Bodies 26%
• 2020

  Parkinson’s disease laterality: a ¹¹C-PE2I PET imaging study

  Barker, R. A., Bjartmarz, H., Björklund, A., Winkler, C. & TRANSEURO consortium, 2020 jan., I: Journal of Neurology.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • N-(3-iodoprop-2-enyl)-2-beta-carbomethoxy-3-(4-methylphenyl)nortropane 100%
  • Corpus Striatum 49%
  • Parkinson Disease 42%
  • Dopamine Plasma Membrane Transport Proteins 15%
  • Movement Disorders 14%

• Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

  Landeck, N., Strathearn, K. E., Ysselstein, D., Buck, K., Dutta, S., Banerjee, S., Lv, Z., Hulleman, J. D., Hindupur, J., Lin, L. K., Padalkar, S., Stanciu, L. A., Lyubchenko, Y. L., Kirik, D. & Rochet, J. C., 2020, I: Molecular Neurodegeneration. 15, 1, 49.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • Synucleinopathies 20%
  • Parkinson Disease 18%
  • Membranes 17%
  • Dopaminergic Neurons 15%

• Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

  Gantner, C. W., de Luzy, I. R., Kauhausen, J. A., Moriarty, N., Niclis, J. C., Bye, C. R., Penna, V., Hunt, C. P. J., Ermine, C. M., Pouton, C. W., Kirik, D., Thompson, L. H. & Parish, C. L., 2020, I: Cell Stem Cell. 26, 4, s. 511-526.e5

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Glial Cell Line-Derived Neurotrophic Factor 100%
  • Parkinson Disease 63%
  • Stem Cells 55%
  • Pluripotent Stem Cells 53%
  • Dopaminergic Neurons 47%
• 2019

  Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia

  Petty, A., Cui, X., Tesiram, Y., Kirik, D., Howes, O. & Eyles, D., 2019, I: npj Schizophrenia. 5, 1, 6.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Dopamine 100%
  • Schizophrenia 96%
  • Animal Models 85%
  • Amphetamine 43%
  • GTP Cyclohydrolase 20%

• Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

  Elfarrash, S., Jensen, N. M., Ferreira, N., Betzer, C., Thevathasan, J. V., Diekmann, R., Adel, M., Omar, N. M., Boraie, M. Z., Gad, S., Ries, J., Kirik, D., Nabavi, S. & Jensen, P. H., 2019, I: Acta Neuropathologica Communications. 7, 1, 213.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • alpha-Synuclein 79%
  • Serine 21%
  • Microinjections 16%
  • Synucleinopathies 10%

• SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease

  Baldo, B., Gabery, S., Soylu-Kucharz, R., Cheong, R. Y., Henningsen, J. B., Englund, E., McLean, C., Kirik, D., Halliday, G. & Petersén, 2019, I: Neuropathology and Applied Neurobiology. 45, 4, s. 361-379

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Huntington Disease 100%
  • Metabolic Networks and Pathways 90%
  • Brain 44%
  • Orexins 43%
  • Lateral Hypothalamic Area 42%
• 2018

  In vivo quantification of glial activation in minipigs overexpressing human α-synuclein

  Lillethorup, T. P., Glud, A. N., Landeck, N., Alstrup, A. K. O., Jakobsen, S., Vang, K., Doudet, D. J., Brooks, D. J., Kirik, D., Hinz, R., Sørensen, J. C. & Landau, A. M., 2018, I: Synapse. 72, 12, e22060.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Miniature Swine 88%
  • Substantia Nigra 70%
  • Neuroglia 58%
  • Dependovirus 48%

• Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs

  Lillethorup, T. P., Glud, A. N., Alstrup, A. K. O., Noer, O., Nielsen, E. H. T., Schacht, A. C., Landeck, N., Kirik, D., Orlowski, D., Sørensen, J. C. H., Doudet, D. J. & Landau, A. M., 2018, I: Scientific Reports. 8, 1, 15715.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Miniature Swine 100%
  • 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile 89%
  • (R)-(11C)1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide 86%
  • Proteasome Endopeptidase Complex 77%
  • lactacystin 74%

• Multivoxel 1H-MR Spectroscopy Biometrics for Preoprerative Differentiation Between Brain Tumors

  Durmo, F., Rydelius, A., Cuellar Baena, S., Askaner, K., Lätt, J., Bengzon, J., Englund, E., Chenevert, T. L., Björkman-Burtscher, I. M. & Sundgren, P. C., 2018 dec., I: Tomography : a journal for imaging research. 4, 4, s. 172-181 10 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Brain Neoplasms 100%
  • Glioma 99%
  • Magnetic Resonance Spectroscopy 90%
  • Choline 78%
  • Neoplasm Metastasis 33%

• Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice

  Hansen, M. G., Ledri, L. N., Kirik, D., Kokaia, M. & Ledri, M., 2018 jan. 9, I: Frontiers in Cellular Neuroscience. 11, 433.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Parvalbumins 100%
  • Synapses 71%
  • gamma-Aminobutyric Acid 37%
  • Seizures 30%
  • Optogenetics 25%

• Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

  Baldo, B., Sajjad, M. U., Cheong, R. Y., Bigarreau, J., Vijayvargia, R., McLean, C., Perrier, A. L., Seong, I. S., Halliday, G., Petersén, Å. & Kirik, D., 2018, I: eNeuro. 5, 4

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Huntingtin Protein 100%
  • Mutant Proteins 73%
  • Huntington Disease 31%
  • polyglutamine 30%
  • Induced Pluripotent Stem Cells 6%
• 2017

  Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats

  Naughton, C., O'Toole, D., Kirik, D. & Dowd, E., 2017 jan. 1, I: Behavioural Brain Research. 316, s. 160-168 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Rotenone 87%
  • Pesticides 73%
  • Parkinson Disease 55%
  • Genes 26%

• Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

  Mandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J. & Kordower, J. H., 2017 juni 16, I: Acta Neuropathologica Communications. 5, 1, s. 47

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Multiple System Atrophy 100%
  • alpha-Synuclein 90%
  • Primates 70%
  • Rodentia 62%
  • Oligodendroglia 55%

• Toxic effects of human and rodent variants of alpha-synuclein in vivo

  Landeck, N., Buck, K. & Kirik, D., 2017 feb. 1, I: European Journal of Neuroscience. 45, 4, s. 536-547 12 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • alpha-Synuclein 100%
  • human SNCB protein 93%
  • Rodentia 69%
  • Poisons 61%
  • rat Snca protein 40%
• 2016

  A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein

  Landeck, N., Hall, H., Ardah, M. T., Majbour, N. K., El-Agnaf, O. M. A., Halliday, G. & Kirik, D., 2016 aug. 22, I: Molecular Neurodegeneration. 11, 1, 125.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • human SNCA protein 100%
  • alpha-Synuclein 75%
  • Parkinson Disease 30%
  • human PLK2 protein 21%
  • Post Translational Protein Processing 18%

• Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T.

  Cuellar-Baena, S., Landeck, N., Sonnay, S., Buck, K., Mlynarik, V., in 't Zandt, R. & Kirik, D., 2016, I: Journal of Neurochemistry. 137, 5, s. 806-819

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • human SNCA protein 100%
  • Ascorbate 70%
  • Lactic Acid 56%
  • Magnetic Resonance Spectroscopy 53%
  • 1H NMR Spectroscopy 52%
• 2015

  A doctor's dilemma

  Kirik, D. & Pain, E., 2015 nov. 20, I: Science (New York, N.Y.). 350, 6263, s. 998

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

  • Sweden 100%
  • Genetic Therapy 94%
  • Career Choice 72%
  • Neurosciences 54%
  • Turkey 54%

• Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.

  Cederfjäll, E., Broom, L. & Kirik, D., 2015, I: Molecular Therapy. 23, 5, s. 896-906

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • GTP Cyclohydrolase 100%
  • Gene Transfer Techniques 81%
  • Dihydrofolates 80%
  • Tetrahydrofolate Dehydrogenase 63%
  • Corpus Striatum 61%
  163 Nedladdningar (Pure)

• Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.

  Soylu, R., Adlesic, N., Baldo, B., Kirik, D. & Petersén, Å., 2015, I: Scientific Reports. 5, 14598.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Brown Adipose Tissue 100%
  • Hypothalamus 75%
  • Huntington Disease 60%
  • Zona Incerta 41%
  • Neuropeptide Receptors 40%
  247 Nedladdningar (Pure)

• Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.

  Kuzdas-Wood, D., Fellner, L., Premstaller, M., Borm, C., Bloem, B., Kirik, D., Wenning, G. K. & Stefanova, N., 2015, I: BMC Neuroscience. 16, 1, 86.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • Multiple System Atrophy 87%
  • Oligodendroglia 72%
  • Corpus Striatum 64%
  • Quinolinic Acid 31%

• Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.

  Buck, K., Landeck, N., Ulusoy, A., Majbour, N. K., El-Agnaf, O. M. A. & Kirik, D., 2015, I: Neurobiology of Disease. 78, Mar 25, s. 100-114

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Substantia Nigra 70%
  • Dopaminergic Neurons 69%
  • Phosphotransferases 51%
  • Phosphorylation 45%

• The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.

  Roybon, L., Mastracci, T. L., Li, J., Stott, S., Leiter, A. B., Sussel, L., Brundin, P. & Li, J-Y., 2015, I: PLoS ONE. 10, 6, e0128035.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Olfactory Bulb 100%
  • Rodentia 72%
  • Transcription Factors 65%
  • Neurons 53%
  • Basic Helix-Loop-Helix Transcription Factors 20%
  183 Nedladdningar (Pure)

• TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells.

  Fasching, L., Kapopoulou, A., Sachdeva, R., Petri, R., Jönsson, M., Männe, C., Turelli, P., Jern, P., Cammas, F., Trono, D. & Jakobsson, J., 2015, I: Cell Reports. 10, 1, s. 20-28

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Endogenous Retroviruses 100%
  • Histone 78%
  • Stem Cells 54%
  • Modification 40%
  • Co-Repressor Proteins 18%
  281 Nedladdningar (Pure)

• Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.

  Gabery, S., Georgiou-Karistianis, N., Hult Lundh, S., Cheong, R., Churchyard, A., Chua, P., Stout, J. C., Egan, G. F., Kirik, D. & Petersén, Å., 2015, I: PLoS ONE. 10, 2, e0117593.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Huntington Disease 100%
  • Hypothalamus 83%
  • Magnetic Resonance Imaging 59%
  • Sleep 17%
  • Emotional Regulation 13%
  425 Nedladdningar (Pure)
• 2014

  Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease.

  Sahin, G., Thompson, L., Lavisse, S., Özgür, M., Rbah-Vidal, L., Dollé, F., Hantraye, P. & Kirik, D., 2014, I: PLoS ONE. 9, 3, e90759.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Dopamine Receptors 100%
  • Dyskinesias 97%
  • Dopamine 74%
  • Parkinson Disease 74%
  • Corpus Striatum 21%
  198 Nedladdningar (Pure)

• Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

  Ledri, M., Grönning Madsen, M., Nikitidou, L., Kirik, D. & Kokaia, M., 2014, I: Journal of Neuroscience. 34, 9, s. 3364-3377

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Optogenetics 100%
  • Interneurons 81%
  • Light 31%
  • Action Potentials 19%
  • Epilepsy 18%
  259 Nedladdningar (Pure)

• Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease

  Moloney, T. C., Hyland, R., O'Toole, D., Paucard, A., Kirik, D., O'Doherty, A., Gorman, A. M. & Dowd, E., 2014, I: CNS Neuroscience & Therapeutics. 20, 1, s. 50-58

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • Dependovirus 81%
  • HSP70 Heat-Shock Proteins 80%
  • alpha-Synuclein 79%
  • Viral Genes 77%

• Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.

  Hall, H., Reyes, S., Landeck, N., Bye, C., Leanza, G., Double, K., Thompson, L., Halliday, G. & Kirik, D., 2014, I: Brain. 137, Jul 24, s. 2493-2508

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Cholinergic Agents 100%
  • Parkinson Disease 89%
  • Dementia 89%
  • Pathology 67%
  • Synucleins 58%

• Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

  Berglind, F., Ledri, M., Sørensen, A. T., Nikitidou, L., Melis, M., Bielefeld, P., Kirik, D., Deisseroth, K., Andersson, M. & Kokaia, M., 2014, I: Neurobiology of Disease. 65, s. 133-141

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Optogenetics 100%
  • Seizures 59%
  • Epilepsy 48%
  • Hippocampus 30%
  • Neurons 23%
  602 Nedladdningar (Pure)
• 2013

  A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

  Hansen, C., Björklund, T., Petit, G., Lundblad, M., Murmu, R., Brundin, P. & Li, J-Y., 2013, I: Neurobiology of Disease. 56C, April,30, s. 145-155

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Green Fluorescent Proteins 70%
  • Bacterial Artificial Chromosomes 36%
  • Parkinson Disease 33%
  • Pars Compacta 17%

• Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration

  Xilouri, M., Brekk, O. R., Landeck, N., Pitychoutis, P. M., Papasilekas, T., Papadopoulou-Daifoti, Z., Kirik, D. & Stefanis, L., 2013, I: Brain. 136, s. 2130-2146

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Chaperone-Mediated Autophagy 100%
  • alpha-Synuclein 71%
  • Substantia Nigra 17%
  • Lysosome-Associated Membrane Glycoproteins 16%
  • Parkinson Disease 9%

• Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors.

  Hall, H., Jewett, M., Landeck, N., Nilsson, N., Schagerlöf, U., Leanza, G. & Kirik, D., 2013, I: PLoS ONE. 8, 5, e64844.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • human SNCA protein 100%
  • Ventral Tegmental Area 77%
  • Cholinergic Agents 59%
  • Dopaminergic Neurons 49%
  • Parkinson Disease 39%
  180 Nedladdningar (Pure)

• Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

  Cederfjäll, E., Nilsson, N., Sahin, G., Chu, Y., Nikitidou, E., Björklund, T., Kordower, J. H. & Kirik, D., 2013, I: Scientific Reports. 3, 2157.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • GTP Cyclohydrolase 100%
  • Tyrosine 3-Monooxygenase 69%
  • Parkinson Disease 53%
  • Primates 16%
  • Behavior Rating Scale 10%
  190 Nedladdningar (Pure)

• Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: Behavior, positron emission tomography, immunohistochemistry

  Mackey, S., Jing, Y., Flores, J., Dinelle, K. & Doudet, D. J., 2013, I: Experimental Neurology. 247, s. 19-24

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • dihydrotetrabenazine 100%
  • Proteasome Inhibitors 90%
  • lactacystin 85%
  • Ubiquitin 76%
  • Positron-Emission Tomography 70%

• Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntingtons disease

  Hult Lundh, S., Nilsson, N., Soylu, R., Kirik, D. & Petersén, Å., 2013, I: Human Molecular Genetics. 22, 17, s. 3485-3497

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Huntington Disease 100%
  • Transgenic Mice 80%
  • Anxiety 40%
  • Depression 29%
  • Psychiatry 25%
  230 Nedladdningar (Pure)

• Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

  Febbraro, F., Sahin, G., Farran, A., Soares, S., Jensen, P. H., Kirik, D. & Romero-Ramos, M., 2013, I: Neurobiology of Disease. 56, s. 47-58

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • alpha-Synuclein 100%
  • Parkinson Disease 69%
  • Pathology 52%
  • Serine 37%
  • Phosphorylation 15%