Utvecklingshematopoes

2023

A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia

Eldeeb, M., Yuan, O., Guzzi, N., Thi Ngoc, P. C., Konturek-Ciesla, A., Kristiansen, T. A., Muthukumar, S., Magee, J., Bellodi, C., Yuan, J. & Bryder, D., 2023 feb. 28, I: Cell Reports. 42, 2, 112099.

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Temporal dynamics of TNF-mediated changes in hematopoietic stem cell function and recovery

Rundberg Nilsson, A., Hidalgo, I., Bryder, D. & Pronk, C. J., 2023 apr. 21, I: iScience. 26, 4, 106341.

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Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

Konturek-Ciesla, A., Dhapola, P., Zhang, Q., Säwén, P., Wan, H., Karlsson, G. & Bryder, D., 2023, I: Cell Reports. 42, 4, 112304.

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2022

Antigen-Presenting B Cells Program the Efferent Lymph T Helper Cell Response

Alsén, S., Cervin, J., Deng, Y., Szeponik, L., Wenzel, U. A., Karlsson, J., Cucak, H., Livingston, M., Bryder, D., Lu, Q., Johansson-Lindbom, B. & Yrlid, U., 2022 mars, I: Frontiers in Immunology. 13, 813203.

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A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut

Vergani, S., Muleta, K. G., Da Silva, C., Doyle, A., Kristiansen, T. A., Sodini, S., Krausse, N., Montano, G., Kotarsky, K., Nakawesi, J., Åkerstrand, H., Vanhee, S., Gupta, S. L., Bryder, D., Agace, W. W., Lahl, K. & Yuan, J., 2022, I: Immunity. 55, 10, s. 1829-1842.e6

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A somatic mutation in moesin drives progression into acute myeloid leukemia

Yuan, O., Ugale, A., de Marchi, T., Anthonydhason, V., Konturek-Ciesla, A., Wan, H., Eldeeb, M., Drabe, C., Jassinskaja, M., Hansson, J., Hidalgo, I., Velasco-Hernandez, T., Cammenga, J., Magee, J. A., Niméus, E. & Bryder, D., 2022, I: Science Advances. 8, 16, eabm9987.

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Bmi1 induction protects hematopoietic stem cells against pronounced long-term hematopoietic stress

Hidalgo, I., Wahlestedt, M., Yuan, O., Zhang, Q., Bryder, D. & Pronk, C. J., 2022, I: Experimental Hematology. 109, s. 35-44

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Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

Safi, F., Dhapola, P., Warsi, S., Sommarin, M., Erlandsson, E., Ungerbäck, J., Warfvinge, R., Sitnicka, E., Bryder, D., Böiers, C., Thakur, R. K. & Karlsson, G., 2022 maj 10, I: Cell Reports. 39, 6, 110798.

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Developmental cues license megakaryocyte priming in murine hematopoietic stem cells

Kristiansen, T. A., Zhang, Q., Vergani, S., Boldrin, E., Krausse, N., André, O., Nordenfelt, P., Sigvardsson, M., Bryder, D., Ungerbäck, J. & Yuan, J., 2022, I: Blood Advances. 6, 24 , s. 6228-6241 27 s.

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Scarf enables a highly memory-efficient analysis of large-scale single-cell genomics data

Dhapola, P., Rodhe, J., Olofzon, R., Bonald, T., Erlandsson, E., Soneji, S. & Karlsson, G., 2022, I: Nature Communications. 13, 4616.

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2021

Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics

Takahashi, M., Barile, M., Chapple, R. H., Tseng, Y. J., Nakada, D., Busch, K., Fanti, A. K., Säwén, P., Bryder, D., Höfer, T. & Göttgens, B., 2021, I: Stem Cell Reports. 16, 4, s. 741-753 13 s.

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2020

Continuous mitotic activity of primitive hematopoietic stem cells in adult mice

Morcos, M. N. F., Zerjatke, T., Glauche, I., Munz, C. M., Ge, Y., Petzold, A., Reinhardt, S., Dahl, A., Anstee, N. S., Bogeska, R., Milsom, M. D., Säwén, P., Wan, H., Bryder, D., Roers, A. & Gerbaulet, A., 2020, I: Journal of Experimental Medicine. 217, 6, e20191284.

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Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis

Yang, W., Trahan, G. D., Howell, E. D., Speck, N. A., Jones, K. L., Gillen, A. E., Riemondy, K., Hesselberth, J., Bryder, D. & Ernst, P., 2020 feb. 11, I: Stem Cell Reports. 14, 2, s. 285-299 15 s.

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2019

Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL-AF9-Driven AML

Velasco-Hernandez, T., Soneji, S., Hidalgo, I., Erlandsson, E., Cammenga, J. & Bryder, D., 2019, I: Stem Cell Reports. 12, 1, s. 112-121 10 s.

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Loss of MafA and MafB expression promotes islet inflammation.

Singh, T., Colberg, J. K., Sarmiento, L., Chaves, P., Hansen, L., Bsharat, S., Cataldo, L. R., Dudenhöffer-Pfeifer, M., Fex, M., Bryder, D., Holmberg, D., Sitnicka, E., Cilio, C., Prasad, R. B. & Artner, I., 2019 juni 24, I: Scientific Reports. 9, 1, 9074.

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2018

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

Säwen, P., Eldeeb, M., Erlandsson, E., Kristiansen, T. A., Laterza, C., Kokaia, Z., Karlsson, G., Yuan, J., Soneji, S., Mandal, P. K., Rossi, D. J. & Bryder, D., 2018 dec. 18, I: eLife. 7, e41258.

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Rapid and efficient induction of functional astrocytes from human pluripotent stem cells

Canals, I., Ginisty, A., Quist, E., Timmerman, R., Fritze, J., Miskinyte, G., Monni, E., Hansen, M. G., Hidalgo, I., Bryder, D., Bengzon, J. & Ahlenius, H., 2018 aug. 20, I: Nature Methods. 15, 9, s. 693-696 4 s.

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SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies

Davidsson, J., Puschmann, A., Tedgård, U., Bryder, D., Nilsson, L. & Cammenga, J., 2018 maj, I: Leukemia. 32, 5, s. 1106-1115

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2017

Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor

Wahlestedt, M., Ladopoulos, V., Hidalgo, I., Sanchez Castillo, M., Hannah, R., Säwén, P., Wan, H., Dudenhöffer-Pfeifer, M., Magnusson, M., Norddahl, G. L., Göttgens, B. & Bryder, D., 2017 nov. 21, I: Cell Reports. 21, 8, s. 2251-2263 13 s.

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Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

Komorowska, K., Doyle, A., Wahlestedt, M., Subramaniam, A., Debnath, S., Chen, J., Soneji, S., Van Handel, B., Mikkola, H. K. A., Miharada, K., Bryder, D., Larsson, J. & Magnusson, M., 2017 dec. 19, I: Cell Reports. 21, 12, s. 3514-3523 10 s.

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Utvecklingshematopoes

A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia

Temporal dynamics of TNF-mediated changes in hematopoietic stem cell function and recovery

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

Antigen-Presenting B Cells Program the Efferent Lymph T Helper Cell Response

A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut

A somatic mutation in moesin drives progression into acute myeloid leukemia

Bmi1 induction protects hematopoietic stem cells against pronounced long-term hematopoietic stress

Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

Developmental cues license megakaryocyte priming in murine hematopoietic stem cells

Scarf enables a highly memory-efficient analysis of large-scale single-cell genomics data

Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics

Continuous mitotic activity of primitive hematopoietic stem cells in adult mice

Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis

Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL-AF9-Driven AML

Loss of MafA and MafB expression promotes islet inflammation.

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

Rapid and efficient induction of functional astrocytes from human pluripotent stem cells

SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies

Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor

Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment

The slippery slope of hematopoietic stem cell aging

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells

Utvecklingshematopoes

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