Glykobiologigruppen

2024

Interplay between glypican-1, amyloid-β and tau phosphorylation in human neural stem cells

Cheng, F., Fransson, L. Å. & Mani, K., 2024 aug., I: Neuroscience. 553, s. 121-127 7 s.

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Dichotomous Effects of Glypican-4 on Cancer Progression and Its Crosstalk with Oncogenes

Chérouvrier Hansson, V., Cheng, F., Georgolopoulos, G. & Mani, K., 2024 apr., I: International Journal of Molecular Sciences. 25, 7, 3945.

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2023

Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells

Cheng, F., Fransson, L. Å. & Mani, K., 2023 apr. 1, I: Glycobiology. 33, 4, s. 325-341 17 s.

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Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior

Cheng, F., Hansson, V. C., Georgolopoulos, G. & Mani, K., 2023, I: Oncotarget. 14, 1, s. 219-235 17 s.

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2022

The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

Wilson, L. F. L., Dendooven, T., Hardwick, S. W., Echevarría-Poza, A., Tryfona, T., Krogh, K. B. R. M., Chirgadze, D. Y., Luisi, B. F., Logan, D. T., Mani, K. & Dupree, P., 2022 juni 8, I: Nature Communications. 13, 3314, 3314.

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Complex modulation of cytokine-induced α-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells

Cheng, F., Fransson, L. Å. & Mani, K., 2022 apr. 1, I: Glycobiology. 32, 4, s. 333-342

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Assays for Evaluation of Substrates for and Inhibitors of β-1,4-Galactosyltransferase 7

Tykesson, E., Persson, A., Mani, K. & Ellervik, U., 2022, Methods in Molecular Biology. Humana Press, s. 477-486 10 s. (Methods in Molecular Biology; vol. 2303).

Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Kapitel samlingsverk › Forskning › Peer review

Isolation and Characterization of Heparan Sulfate Containing Amyloid Precursor Protein Degradation Products

Mani, K., 2022, Methods in Molecular Biology. Humana Press, s. 279-288 10 s. (Methods in Molecular Biology; vol. 2303).

Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Kapitel samlingsverk › Forskning › Peer review

Production and HPLC-Based Disaccharide Analysis of Xyloside-Primed Glycosaminoglycans

Persson, A., Tykesson, E., Ellervik, U. & Mani, K., 2022, Methods in Molecular Biology. Humana Press, s. 173-182 10 s. (Methods in Molecular Biology; vol. 2303).

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2021

Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1

Cheng, F., Fransson, L. Å. & Mani, K., 2021 aug. 7, I: Glycobiology. 31, 7, s. 800-811 12 s.

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2020

Proinflammatory cytokines induce accumulation of glypican-1-derived heparan sulfate and the C-terminal fragment of β-cleaved APP in autophagosomes of dividing neuronal cells

Cheng, F., Fransson, L. Å. & Mani, K., 2020, I: Glycobiology. 30, 8, s. 539-549 11 s.

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2019

The cyanobacterial neurotoxin β-N-methylamino-L-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells

Cheng, F., Fransson, L. Å. & Mani, K., 2019, I: Experimental Cell Research. 379, 2, s. 172-181 10 s.

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2018

The GAGOme: a cell-based library of displayed glycosaminoglycans

Chen, Y. H., Narimatsu, Y., Clausen, T. M., Gomes, C., Karlsson, R., Steentoft, C., Spliid, C. B., Gustavsson, T., Salanti, A., Persson, A., Malmström, A., Willén, D., Ellervik, U., Bennett, E. P., Mao, Y., Clausen, H. & Yang, Z., 2018 nov., I: Nature Methods. 15, 11, s. 881-888

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Fine-tuning the structure of glycosaminoglycans in living cells using xylosides

Persson, A., Ellervik, U. & Mani, K., 2018 juli 1, I: Glycobiology. 28, 7, s. 499-511 13 s.

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Structural and Biophysical Characterization of Human EXTL3: Domain Organization, Glycosylation, and Solution Structure

Awad, W., Kjellström, S., Svensson Birkedal, G., Mani, K. & Logan, D. T., 2018 feb. 20, I: Biochemistry. 57, 7, s. 1166-1177 12 s.

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LC-MS/MS characterization of xyloside-primed glycosaminoglycans with cytotoxic properties reveals structural diversity and novel glycan modifications

Persson, A., Toledo, A. G., Vorontsov, E., Nasir, W., Willén, D., Noborn, F., Ellervik, U., Mani, K., Nilsson, J. & Larson, G., 2018 jan. 1, I: Journal of Biological Chemistry. 293, 26, s. 10202-10219 18 s.

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Common traffic routes for imported spermine and endosomal glypican-1-derived heparan sulfate in fibroblasts

Cheng, F., Fransson, L. Å. & Mani, K., 2018, I: Experimental Cell Research. 364, 2, s. 133-142

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2017

Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1

Cheng, F., Fransson, L. Å. & Mani, K., 2017, I: Experimental Cell Research. 360, 2, s. 171-179

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Nucleolin is a nuclear target of heparan sulfate derived from glypican-1

Cheng, F., Belting, M., Fransson, L. Å. & Mani, K., 2017, I: Experimental Cell Research. 354, 1, s. 31-39

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228 Nedladdningar (Pure)

Structural and Functional Analyses of Xyloside-primed Glycosaminoglycans

Persson, A., 2017, Lund: Lund University: Faculty of Medicine. 93 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

2016

Xyloside-primed chondroitin sulfate/dermatan sulfate from breast carcinoma cells with a defined disaccharide composition has cytotoxic effects in vitro

Persson, A., Tykesson, E., Westergren-Thorsson, G., Malmström, A., Ellervik, U. & Mani, K., 2016 juli, I: Journal of Biological Chemistry. 291, 28, s. 14871-14882 12 s.

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Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.

Cheng, F., Bourseau-Guilmain, E., Belting, M., Fransson, L.-Å. & Mani, K., 2016, I: Glycobiology. 26, 6, s. 623-634 12 s.

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460 Nedladdningar (Pure)

2015

Exploration of the active site of β4GalT7: modifications of the aglycon of aromatic xylosides.

Siegbahn, A., Thorsheim, K., Ståhle, J., Manner, S., Hamark, C., Persson, A., Tykesson, E., Mani, K., Westergren-Thorsson, G., Widmalm, G. & Ellervik, U., 2015, I: Organic and Biomolecular Chemistry. 13, 11, s. 3351-3362

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212 Nedladdningar (Pure)

Rapid nuclear transit and impaired degradation of amyloid beta and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts.

Cheng, F., Fransson, L.-Å. & Mani, K., 2015, I: Glycobiology. 25, 5, s. 548-556

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Structural aspects of N-glycosylations and the C-terminal region in human glypican-1.

Awad, W., Adamczyk, B., Örnros, J., Karlsson, N. G., Mani, K. & Logan, D. T., 2015, I: Journal of Biological Chemistry. 290, 38, s. 22991-23008

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Suppression of glypican-1 autodegradation by NO-deprivation correlates with nuclear accumulation of amyloid beta in normal fibroblasts.

Cheng, F., Fransson, L.-Å. & Mani, K., 2015, I: Glycoconjugate Journal. 32, 9, s. 675-684

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2014

APP/APLP2 expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.

Cheng, F., Cappai, R., Lidfeldt, J., Belting, M., Fransson, L.-Å. & Mani, K., 2014, I: Journal of Biological Chemistry. 289, 30, s. 20871-20878

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231 Nedladdningar (Pure)

GPC1 (glypican 1)

Abdelhady, W. A., Logan, D. & Mani, K., 2014, I: Atlas of Genetics and Cytogenetics in Oncology and Haematology. 18, 7, s. 461-464

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Rules for priming and inhibition of glycosaminoglycan biosynthesis; probing the beta 4GalT7 active site

Siegbahn, A., Manner, S., Persson, A., Tykesson, E., Thorsheim, K., Ochocinska, A., Ronnols, J., Sundin, A., Mani, K., Westergren-Thorsson, G., Widmalm, G. & Ellervik, U., 2014, I: Chemical Science. 5, 9, s. 3501-3508

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Short and efficient synthesis of a daunosamine donor from L-fucal

Ohlin, M., Manner, S., Lofgren, J., Persson, A. & Ellervik, U., 2014, I: RSC Advances. 4, 24, s. 12486-12489

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2013

Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration.

Awad, W., Svensson Birkedal, G., Thunnissen, M. M. G. M., Mani, K. & Logan, D. T., 2013, I: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 12, s. 2524-2533

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Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products

Cheng, F., Ruscher, K., Fransson, L.-Å. & Mani, K., 2013, I: Glycobiology. 23, 12, s. 1510-1519

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Synthesis and biology of oligoethylene glycol linked naphthoxylosides.

Thorsheim, K., Persson, A., Johnsson, R., Löfgren, J., Mani, K. & Ellervik, U., 2013, I: Bioorganic & Medicinal Chemistry. 21, 11, s. 3310-3317

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336 Nedladdningar (Pure)

Tumor Selective Antiproliferative Naphthoxylosides

Aili, U., 2013, Glycobiology, Dept of Experimental Medical Science. 94 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

2012

Crystal structure of N-glycosylated human glypican-1 core protein: Structure of two loops evolutionarily conserved in vertebrate glypican-1.

Svensson Birkedal, G., Awad, W., Håkansson, M., Mani, K. & Logan, D., 2012, I: Journal of Biological Chemistry. 287, 17, s. 14040-14051

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151 Nedladdningar (Pure)

Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage.

Cheng, F., Svensson Birkedal, G., Fransson, L.-Å. & Mani, K., 2012, I: Glycobiology. 22, 11, s. 1480-1485

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2011

Characterization and Crystallization of Anchorless Glypican-1

Svensson Birkedal, G., 2011, Department of Experimental Medical Science, Lund Univeristy. 125 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Suppression of amyloid beta a11-immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, no-catalyzed degradation.

Cheng, F., Cappai, R., Ciccotosto, G. D., Svensson Birkedal, G., Multhaup, G., Fransson, L.-Å. & Mani, K., 2011, I: Journal of Biological Chemistry. 286, 31, s. 27559-27572

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166 Nedladdningar (Pure)

Synthesis, conformation and biology of naphthoxylosides.

Siegbahn, A., Aili, U., Ochocinska, A., Olofsson, M., Rönnols, J., Mani, K., Widmalm, G. & Ellervik, U., 2011, I: Bioorganic & Medicinal Chemistry. 19, s. 4114-4126

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The Structural Role of N-Linked Glycans on Human Glypican-1

Svensson Birkedal, G., Wittsten, A. H., Linse, S. & Mani, K., 2011, I: Biochemistry. 50, 43, s. 9377-9387

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2010

Attenuation of tumor growth by formation of antiproliferative glycosaminoglycans correlates with low acetylation of histone H3.

Aili, U., Johnsson, R., Fransson, L.-Å., Ellervik, U. & Mani, K., 2010, I: Cancer Research. 70, 9, s. 3771-3779

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2009

Antiproliferative effects of peracetylated naphthoxylosides.

Aili, U., Jacobsson, M., Johnsson, R., Mani, K. & Ellervik, U., 2009, I: Bioorganic & Medicinal Chemistry Letters. 19, s. 1763-1766

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Chemical and Thermal Unfolding of Glypican-1: Protective Effect of Heparan Sulfate against Heat-Induced Irreversible Aggregation

Svensson Birkedal, G., Linse, S. & Mani, K., 2009, I: Biochemistry. 48, 42, s. 9994-10004

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Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.

Cheng, F., Johnsson, R., Nilsson, J., Fransson, L.-Å., Ellervik, U. & Mani, K., 2009, I: Cancer Letters. 273, s. 148-154

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S-Nitrosylation of secreted recombinant human glypican-1.

Svensson Birkedal, G. & Mani, K., 2009, I: Glycoconjugate Journal. 26, s. 1247-1257

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2008

2007

Effects of oxygen-sulfur substitution on glycosaminoglycan-priming naphthoxylosides.

Jacobsson, M., Mani, K. & Ellervik, U., 2007, I: Bioorganic & Medicinal Chemistry. 15, 15, s. 5283-5299

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Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis

Johnsson, R., Mani, K. & Ellervik, U., 2007, I: Bioorganic & Medicinal Chemistry Letters. 17, 8, s. 2338-2341

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Glykobiologigruppen

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