Retinal degeneration: Molekylär patologi

Forskningsoutput

Forskningsoutput per år 1982 1982 1984 1985 1998 2018 2019 2021 2022 2023 2024

• 26 Artikel i vetenskaplig tidskrift
• 3 Doktorsavhandling (sammanläggning)
• 2 Översiktsartikel
• 1 Kapitel samlingsverk

Forskningsoutput per år

Forskningsoutput per år

Sökresultat

• 2024

  Integrative Kinase Activity Profiling and Phosphoproteomics of rd10 Mouse Retina during cGMP-Dependent Retinal Degeneration

  Roy, A., Zhou, J., Nolet, M., Welinder, C., Zhu, Y., Paquet-Durand, F., Groten, J., Tomar, T. & Ekström, P., 2024 mars, I: International Journal of Molecular Sciences. 25, 6, 3446.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Kinase 100%
  • Phosphotransferase 100%
  • Phosphoproteomics 100%
  • Peptide 40%
  • CREB 40%
• 2023

  The Phosphoproteome of the Rd1 Mouse Retina, a Model of Inherited Photoreceptor Degeneration, Changes after Protein Kinase G Inhibition

  Zhou, J., Welinder, C. & Ekström, P., 2023 juni, I: International Journal of Molecular Sciences. 24, 12, 9836.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Gene 100%
  • Gene Therapy 100%
  • Protein 100%
  • Mouse Model 100%
  • Peptide 100%

• Pyruvate Kinase 2, an Energy Metabolism Related Enzyme, May Have a Neuroprotective Function in Retinal Degeneration

  Zhou, J. & Ekström, P., 2023, I: ASN Neuro. 15

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Retinal Degeneration 100%
  • Enzyme 100%
  • Neuroprotective Agent 100%
  • Wellbeing 50%
  • Glucose Transporter 50%

• The photoreceptor protective cGMP-analog Rp-8-Br-PET-cGMPS interacts with cGMP-interactors PKGI, PDE1, PDE6, and PKAI in the degenerating mouse retina

  Rasmussen, M., Tolone, A., Paquet-Durand, F., Welinder, C., Schwede, F. & Ekström, P., 2023, I: Journal of Comparative Neurology. 531, 8, s. 935-951 17 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Photoreceptor 100%
  • Positron Emission Tomography 100%
  • Retina 100%
  • Cyclic Guanosine Monophosphate 100%
  • Protein Binding 40%
• 2022

  A Potential Role of Cyclic Dependent Kinase 1 (CDK1) in Late Stage of Retinal Degeneration

  Zhou, J. & Ekström, P., 2022 juli 7, I: Cells. 11, 14, 2143.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Retinal Degeneration 100%
  • Photoreceptor 33%
  • Neurodegeneration 16%
  • In Vivo 16%
  • Cell Death 16%

• The stereospecific interaction sites and target specificity of cGMP analogs in mouse cortex

  Rasmussen, M., Welinder, C., Schwede, F. & Ekström, P., 2022, I: Chemical Biology and Drug Design. 99, 2, s. 206-221

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Stereospecificity 100%
  • Protein 66%
  • Binding Site 33%
  • Binding Protein 33%
  • Phosphate 33%
• 2021

  The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach

  Rasmussen, M., Welinder, C., Schwede, F. & Ekström, P., 2021 juni 1, I: Journal of Neurochemistry. 157, 6, s. 2173-2186 14 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Protein 100%
  • Proteomics 100%
  • Photoreceptor 60%
  • Retinal Degeneration 40%
  • Vision 20%
  187 Nedladdningar (Pure)

• cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology

  Zhou, J., Rasmussen, M. & Ekström, P., 2021, I: Experimental Eye Research. 212, 108752.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Retinitis pigmentosa 100%
  • Gene 100%
  • Retina 100%
  • Explant 66%
  • Phosphorylation 50%
• 2019

  Modulation of Calcium Overload and Calpain Activity

  Paquet-Durand, F., Ekström, P. & Marigo, V., 2019, I: RSC Drug Discovery Series. 2019-January, 66, s. 48-60 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Calcium 100%
  • Homeostasis 66%
  • Photoreceptor 66%
  • Light 33%
  • Cell Membrane 33%

• Modulation of cGMP-signalling to Prevent Retinal Degeneration

  Marigo, V., Ekström, P., Schwede, F., Rentsch, A. & Paquet-Durand, F., 2019, I: RSC Drug Discovery Series. 2019-January, 66, s. 88-98 11 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Retinal Degeneration 100%
  • Cyclic Guanosine Monophosphate 100%
  • Photoreceptor 57%
  • Retina 14%
  • Genetics 14%
• 2018

  Acute tissue reactions, inner segment pathology, and effects of the antioxidant α1-microglobulin in an in vitro model of retinal detachment

  Ghosh, F., Åkerström, B., Bergwik, J., Abdshill, H., Gefors, L. & Taylor, L., 2018 apr. 18, I: Experimental Eye Research. 173, s. 13-23 11 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Explant 100%
  • Heat Shock Protein 100%
  • Microglobulin 100%
  • Retinal Detachment 100%
  • Retina 100%

• Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

  Vighi, E., Trifunovic, D., Veiga-Crespo, P., Rentsch, A., Hoffmann, D., Sahaboglu, A., Strasser, T., Kulkarni, M., Bertolotti, E., Van Den Heuvel, A., Peters, T., Reijerkerk, A., Euler, T., Ueffing, M., Schwede, F., Genieser, H. G., Gaillard, P., Marigo, V., Ekström, P. & Paquet-Durand, F., 2018 mars 27, I: Proceedings of the National Academy of Sciences of the United States of America. 115, 13, s. E2997-E3006

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Drug Delivery System 100%
  • Retina Degeneration 100%
  • Cyclic Guanosine Monophosphate 100%
  • Therapeutic Procedure 28%
  • Disease 28%
• 2006

  Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina.

  Azadi, S., Paquet-Durand, F., Medstrand, P., van Veen, T. & Ekström, P., 2006, I: Molecular and Cellular Neuroscience. 31, 4, s. 759-773

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Retina 100%
  • Phosphorylation 100%
  • Photoreceptor 40%
  • Isoform 33%
  • Gene 20%
• 2005

  Decreased glutathione transferase levels in rd1/rd1 mouse retina: Replenishment protects photoreceptors in retinal explants.

  Ahuja, P., Caffé, R., Ahuja, S. P., Ekström, P. & van Veen, T., 2005, I: Neuroscience. 131, 4, s. 935-943

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Photoreceptor 100%
  • Retina 100%
  • Staining Technique 11%
  • Ganglion Cell 11%
  • Suppression 11%
• 2000

  Leukemia inhibitory factor null mice: Unhampered in vitro outgrowth of sensory axons but reduced stimulatory potential by nerve segments

  Ekström, P. A. R., Kerekes, N. & Hökfelt, T., 2000 mars 10, I: Neuroscience Letters. 281, 2-3, s. 107-110 4 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Dorsal Root Ganglion 100%
  • In Vivo 33%
  • Sciatic Nerve 33%
• 1999

  Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neurons

  Wiklund, P. & Ekström, P., 1999 nov. 19, I: Neuroscience Letters. 275, 3, s. 155-158 4 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
• 1998

  The immune modulator Linomide prevents neuronal death in injured peripheral nerves of the mouse

  Ekström, P., Hedlund, G., Karlsson, J. & Andersson, G., 1998 maj 11, I: NeuroReport. 9, 7, s. 1337-1341 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Neuronal Death 100%
  • Peripheral Nerve 100%
  • Cell Death 50%
  • Nervous System Disorder 50%
  • Neuron 50%

• Use of explant cultures of peripheral nerves of adult vertebrates to study axonal regeneration in vitro

  Tonge, D., Edström, A. & Ekström, P., 1998 mars 2, I: Progress in Neurobiology. 54, 4, s. 459-480 22 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Peripheral Nerve 100%
  • Axoplasmic Transport 20%
  • Dorsal Root Ganglion 20%
• 1997

  Effects of glial cell line-derived neurotrophic factor on axonal growth and apoptosis in adult mammalian sensory neurons in vitro

  Leclere, P., Ekström, P., Edström, A., Priestley, J., Averill, S. & Tonge, D. A., 1997 okt. 17, I: Neuroscience. 82, 2, s. 545-558

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Neuron 100%
  • Gene 50%
  • Calcitonin 50%
  • Neurotrophin 50%
  • Staining Technique 25%
• 1991

  A Fast Axonally Transported Protein of the Frog Sciatic Sensory Axons Undergoes Similar Qualitative Changes During Regeneration In Vitro and In Vivo

  Remgård, P., Ekström, P. A. R. & Edström, A., 1991, I: Journal of Neurochemistry. 57, 6, s. 1907-1912 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • In Vivo 100%
• 1985

  Effect of Estramustine Phosphate on the Assembly of Isolated Bovine Brain Microtubules and Fast Axonal Transport in the Frog Sciatic Nerve

  Kanje, M., Ekström, P., Edström, A., Deinum, J., Wallin, M. & Hartley-Asp, B., 1985 maj 1, I: Cancer Research. 45, 5, s. 2234-2239 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Phosphate 100%
  • Prostate Carcinoma 100%

• Ca2+-activated protease activity in frog sciatic nerve: Characterization and effect on rapidly transported axonal proteins

  Kanje, M., Lazarewicz, J., Ekström, P. & Edström, A., 1985 feb. 18, I: Brain Research. 327, 1-2, s. 29-36 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Protein 100%
  • Protease 100%
  • Sciatic Nerve 100%
  • Homogenate 28%
  • Protein Catabolism 14%
• 1984

  Inhibition of Fast Axonal Transport by erythro‐9‐[3‐(2‐Hydroxynonyl)]Adenine

  Ekström, P. & Kanje, M., 1984, I: Journal of Neurochemistry. 43, 5, s. 1342-1345 4 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Adenosine Triphosphatase 100%
  • Phosphate 50%

• Is protease activity involved in fast axonal transport?

  EDSTRÖM, A., EKSTRÖM, P. & KANJE, M., 1984, I: Acta Physiologica Scandinavica. 121, 4, s. 379-384 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Fast Axonal Transport 100%
  • Axoplasmic Transport 50%
  • Neurofilament 25%
  • Sciatic Nerve 25%
• 1982

  Divalent cations and fast axonal transport in chemically desheathed (triton X-treated) frog sciatic nerve

  Kanje, M., Edström, A. & Ekström, P., 1982 juni 3, I: Brain Research. 241, 1, s. 67-74 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Calcium Ion 100%
  • Solution 30%
  • Ringer Solution 20%
  • Smooth Muscle 20%
  • Triton X-100 20%

• Effects of phenothiazines and dibenzazepines on axonal transport and microtubule assembly in vitro

  EKSTRÖM, P., KANJE, M. & EDSTRÖM, A., 1982, I: Acta Physiologica Scandinavica. 116, 2, s. 121-125 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Dibenzazepine Derivative 100%
  • Lofepramine 50%
  • Thioridazine 50%
  • Chlorpromazine 25%