Stem Cells and Leukemia

Forskningsoutput

Forskningsoutput per år 2015 2017 2018 2021 2022 2023 2024

• 25 Artikel i vetenskaplig tidskrift
• 6 Doktorsavhandling (sammanläggning)
• 2 Översiktsartikel
• 1 Preprint (i preprint-arkiv)

Forskningsoutput per år

Forskningsoutput per år

Sökresultat

• 2024

  Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation

  Huuhtanen, J., Adnan-Awad, S., Theodoropoulos, J., Forstén, S., Warfvinge, R., Dufva, O., Bouhlal, J., Dhapola, P., Duàn, H., Laajala, E., Kasanen, T., Klievink, J., Ilander, M., Jaatinen, T., Olsson-Strömberg, U., Hjorth-Hansen, H., Burchert, A., Karlsson, G., Kreutzman, A. & Lähdesmäki, H. & 1 andra, Mustjoki, S., 2024, I: Leukemia. 38, 1, s. 109–125 17 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Antigen Recognition 100%
  • Single Cell Analysis 100%
  • Chronic Myeloid Leukemia 100%
  • Protein Tyrosine Kinase Inhibitor 100%
  • Natural Killer Cell 44%

• Single-cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response

  Fritze, J., Lang, S., Sommarin, M., Soneji, S. & Ahlenius, H., 2024, I: Frontiers in Neuroscience. 18, 1400963.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång
• 2023

  Single-cell multiomics of human fetal hematopoiesis define a developmental-specific population and a fetal signature

  Sommarin, M. N. E., Olofzon, R., Palo, S., Dhapola, P., Soneji, S., Karlsson, G. & Böiers, C., 2023 sep., I: Blood Advances. 7, 18, s. 5325-5340 16 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Cells 100%
  • Blood 100%
  • Adult 80%
  • Gene 66%
  • Hematopoietic Stem Cell 66%

• In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations

  Safi, F., Dhapola, P., Erlandsson, E., Ulfsson, L. G., Calderón, A. S., Böiers, C. & Karlsson, G., 2023 mars 17, I: STAR Protocols. 4, 1, 101965.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Experiment 100%
  • Hematopoietic Stem Cell 100%

• Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays.

  Safi, F., 2023, Lund: Lund University, Faculty of Medicine. 107 s.

  Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

  Öppen tillgång

  Fil

  • Lineages 100%
  • Differentiation 39%
  • Cell Surface 19%
  • Mouse 10%
  • Transcription Factors 10%
  240 Nedladdningar (Pure)

• Human Bone Marrow Microenvironment in Health and Disease

  Bräunig, S., 2023, Lund: Lund University, Faculty of Medicine. 89 s.

  Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

  Öppen tillgång

  Fil

  • Disease 100%
  • Health 100%
  • Bone Marrow 100%
  • Bone Marrow Microenvironment 100%
  • Stem Cell 75%
  259 Nedladdningar (Pure)

• Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

  Li, H., Bräunig, S., Dhapolar, P., Karlsson, G., Lang, S. & Scheding, S., 2023, I: eLife. 12, e81656.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Stromal Cell 100%
  • Bone Marrow 100%
  • Hematopoiesis 50%
  • Velocity 33%
  • RNA 33%

• Pediatric Leukemia: Mechanisms of Initiation and Suppression

  Eldeeb, M., 2023, Lund: Lund University, Faculty of Medicine. 94 s.

  Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

  Öppen tillgång

  Fil
  226 Nedladdningar (Pure)

• Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

  Konturek-Ciesla, A., Dhapola, P., Zhang, Q., Säwén, P., Wan, H., Karlsson, G. & Bryder, D., 2023, I: Cell Reports. 42, 4, 112304.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Differentiation 100%
  • Lymphopoiesis 33%
  • Immunity 16%
  • Transplant Procedure 16%
  • Lineages 16%
• 2022

  Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

  Safi, F., Dhapola, P., Warsi, S., Sommarin, M., Erlandsson, E., Ungerbäck, J., Warfvinge, R., Sitnicka, E., Bryder, D., Böiers, C., Thakur, R. K. & Karlsson, G., 2022 maj 10, I: Cell Reports. 39, 6, 110798.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Chromatin 100%
  • Hematopoietic Stem Cell 100%
  • Lineages 100%
  • Differentiation 28%
  • Myeloid 25%

• Genome-wide association study on 13 167 individuals identifies regulators of blood CD34⁺cell levels

  Lopez de Lapuente Portilla, A., Ekdahl, L., Cafaro, C., Ali, Z., Miharada, N., Thorleifsson, G., Žemaitis, K., Lamarca Arrizabalaga, A., Thodberg, M., Pertesi, M., Dhapola, P., Bao, E., Niroula, A., Bali, D., Norddahl, G., Ugidos Damboriena, N., Sankaran, V. G., Karlsson, G., Thorsteinsdottir, U. & Larsson, J. & 2 andra, Stefansson, K. & Nilsson, B., 2022 mars 17, I: Blood. 139, 11, s. 1659-1669 11 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Genome-Wide Association Study 100%
  • Hematopoietic Stem Cell 100%
  • CXCR4 18%
  • Chromatin 9%
  • Genetic Variation 9%

• Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems

  Dhapola, P., 2022, Lund: Lund University, Faculty of Medicine. 91 s.

  Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

  • Hematopoietic Stem Cell 100%
  • Hematopoietic System 100%
  • Chromatin 22%
  • Defence Mechanisms 22%
  • RNA Sequencing 22%

• Novel Insights into Haematopoietic Stem Cell Regulation and Function

  Warsi, S., 2022, Lund: Lund University, Faculty of Medicine. 82 s.

  Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

  Öppen tillgång

  Fil

  • Regulatory Mechanism 100%
  • Hematopoietic Stem Cell 100%
  • Conditioning 27%
  • Mouse Model 9%
  • Cell Function 9%
  201 Nedladdningar (Pure)

• Scarf enables a highly memory-efficient analysis of large-scale single-cell genomics data

  Dhapola, P., Rodhe, J., Olofzon, R., Bonald, T., Erlandsson, E., Soneji, S. & Karlsson, G., 2022, I: Nature Communications. 13, 4616.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Sampling 100%
  • Experiment 100%
  • RNA Sequencing 100%
  • Embedding 100%
  • Single-Cell Analysis 100%

• Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells

  Warsi, S., Dahl, M., Smith, E. M. K., Rydström, A., Mansell, E., Sigurdsson, V., Sjöberg, J., Soneji, S., Rörby, E., Siva, K., Grahn, T. H. M., Liu, Y., Blank, U., Karlsson, G. & Karlsson, S., 2022, I: Haematologica. 107, 12, s. 2884-2896 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Hematopoietic Stem Cell 100%
  • Regulatory Mechanism 25%
  • Cell Proliferation 25%
  • Transplant Procedure 25%
  • Protein 16%
• 2021

  CellexalVR: A virtual reality platform to visualize and analyze single-cell omics data

  Legetth, O., Rodhe, J., Lang, S., Dhapola, P., Wallergård, M. & Soneji, S., 2021 nov., I: iScience. 24, 11, 103251.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

• Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs

  Pfisterer, U., Bräunig, J., Brattås, P., Heidenblad, M., Karlsson, G. & Fioretos, T., 2021 juli 1, I: Genes, Chromosomes and Cancer. 60, 7, s. 504-524 21 s.

  Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

  Öppen tillgång

  • Single Cell Analysis 100%
  • Single-Cell Sequencing 100%
  • Malignant Neoplasm 100%
  • Single-Cell Analysis 66%
  • Transcriptome 50%

• Genome-wide association study on 13,167 individuals identifies regulators of hematopoietic stem and progenitor cell levels in human blood

  Lopez de Lapuente Portilla, A., Ekdahl, L., Cafaro, C., Ali, Z., Miharada, N., Thorleifsson, G., Zemaitis, K., Lamarca Arrizabalaga, A., Thodberg, M., Pertesi, M., Dhapola, P., Bao, E. L., Niroula, A., Bali, D., Norddahl, G. L., Ugidos Damboriena, N., Sankaran, V. G., Karlsson, G., Thorsteinsdottir, U. & Larsson, J. & 2 andra, Stefánsson, K. & Nilsson, B., 2021 apr. 3, bioRxiv.

  Forskningsoutput: Working paper/Preprint › Preprint (i preprint-arkiv)

  • Genome-Wide Association Study 100%
  • Hematopoietic Stem Cell 100%
  • Gene 9%
  • Human 9%
  • Regulatory Mechanism 9%

• Defining the Emerging Blood System During Development at Single-Cell Resolution

  Karlsson, G., Sommarin, M. N. E. & Böiers, C., 2021, I: Frontiers in Cell and Developmental Biology. 9, 660350.

  Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

  Öppen tillgång

  • Cells 100%
  • Development 100%
  • Blood 100%
  • Hematopoiesis 100%
  • Hematopoietic Stem Cell 50%

• Human Primary Airway Basal Cells Display a Continuum of Molecular Phases from Health to Disease in Chronic Obstructive Pulmonary Disease

  Wijk, S. C., Prabhala, P., Michaliková, B., Sommarin, M., Doyle, A., Lang, S., Kanzenbach, K., Tufvesson, E., Lindstedt, S., Leigh, N. D., Karlsson, G., Bjermer, L., Westergren Thorsson, G. & Magnusson, M., 2021, I: American Journal of Respiratory Cell and Molecular Biology. 65, 1, s. 103-113

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Gene 100%
  • Basal Cell 100%
  • Regeneration 66%
  • Cell Culture 66%
  • Phenotype 33%

• Resolving the Cellular Heterogeneity of Human Hematopoietic Stem and Progenitor Cells. The influence of cellular heterogeneity on ontogeny, ageing and leukemia.

  Sommarin, M., 2021, Lund: Lund University, Faculty of Medicine. 82 s.

  Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

  Öppen tillgång

  Fil
  210 Nedladdningar (Pure)
• 2020

  S100A6 is a critical regulator of hematopoietic stem cells.

  Tan Grahn, H. M., Niroula, A., Vegvari, A., Oburoglu, L., Pertesi, M., Warsi, S., Safi, F., Miharada, N., C. Garcia, S., Siva, K., Liu, Y., Rörby, E., Nilsson, B., Zubarev, R. A. & Karlsson, S., 2020 juni 19, I: Leukemia.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Hematopoietic Stem Cell 100%
  • Calcium 16%
  • Stem Cell Self-Renewal 16%
  • Protein 8%
  • Reduction (Chemistry) 8%

• Loss of Cxcr5 alters neuroblast proliferation and migration in the aged brain

  Fritze, J., Ginisty, A., McDonald, R., Quist, E., Stamp, E., Monni, E., Dhapola, P., Lang, S. & Ahlenius, H., 2020, I: Stem Cells. 38, 9, s. 1175-1187

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Brain 100%
  • Inflammation 75%
  • Neuron 50%
  • Rostral Migratory Stream 25%
  • Chemokine 25%
• 2018

  Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

  Säwen, P., Eldeeb, M., Erlandsson, E., Kristiansen, T. A., Laterza, C., Kokaia, Z., Karlsson, G., Yuan, J., Soneji, S., Mandal, P. K., Rossi, D. J. & Bryder, D., 2018 dec. 18, I: eLife. 7, e41258.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Aging 100%
  • Adult 71%
  • Age 28%
  • Lineages 28%
  • Lifespan 14%

• Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

  Bartoschek, M., Oskolkov, N., Bocci, M., Lövrot, J., Larsson, C., Sommarin, M., Madsen, C., Lindgren, D., Pekar, G., Karlsson, G., Ringnér, M., Bergh, J., Björklund, Å. K. & Pietras, K., 2018 dec. 4, I: Nature Communications. 9, 1, 5150.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Gene 100%
  • Protein 100%
  • Mouse Model 100%
  • Fat 100%

• A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

  Sommarin, M. N. E., Warfvinge, R., Safi, F. & Karlsson, G., 2018 okt. 25, I: Journal of visualized experiments : JoVE. 140

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Fluorescence Activated Cell Sorting 100%
  • Volume 66%
  • Gene Expression Profiling 66%
  • Gene 33%
  • Synthesis 33%

• Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis

  Jensen, C. T., Åhsberg, J., Sommarin, M. N. E., Strid, T., Somasundaram, R., Okuyama, K., Ungerbäck, J., Kupari, J., Airaksinen, M. S., Lang, S., Bryder, D., Soneji, S., Karlsson, G. & Sigvardsson, M., 2018 juli 2, I: Journal of Experimental Medicine. 215, 7, s. 1947-1963 17 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Lymphopoiesis 100%
  • Lineages 66%
  • Gene 50%
  • In Vivo 50%
  • Expression Analysis 50%
• 2017

  Don't judge a cell by its cover: heterogeneity within early lymphoid progenitors

  Karlsson, G., Sigvardsson, M. & Böiers, C., 2017 dec. 15, I: EMBO Journal. 36, 24, s. 3552-3554 3 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

• The stem cell regulator PEDF is dispensable for maintenance and function of hematopoietic stem cells

  Rörby, E., Billing, M., Dahl, M., Warsi, S., Andradottir, S., Miharada, K., Siva, K., Jönsson, J.-I., Blank, U., Karlsson, G. & Karlsson, S., 2017 aug. 31, I: Scientific Reports. 7, 10134.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Transplant Procedure 100%
  • Growth 100%
  • Lineages 50%
  • Hematopoietic System 50%

• Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition

  Guibentif, C., Rönn, R. E., Böiers, C., Lang, S., Saxena, S., Soneji, S., Enver, T., Karlsson, G. & Woods, N.-B., 2017 apr. 4, I: Cell Reports. 19, 1, s. 10-19 10 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Single-Cell Analysis 100%
  • Hematopoietic Cell 100%
  • Single Cell Analysis 100%
  • Gene 50%
  • Hematopoietic Stem Cell 50%

• Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

  Warfvinge, R., Geironson Ulfsson, L., Sommarin, M. N. E., Lang, S., Karlsson, C., Roschupkina, T., Stenke, L., Stentoft, J., Olsson-Strömberg, U., Hjorth-Hansen, H., Mustjoki, S., Soneji, S., Richter, J. & Karlsson, G., 2017 apr., I: Blood. 129, 17, s. 2384-2394

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Myeloid 100%
  • Cell Subpopulation 100%
  • Tyrosine Kinase Inhibitor 71%
  • Cell Population 37%
  • Surface Property 14%
• 2016

  Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

  Capellera-Garcia, S., Pulecio, J., Dhulipala, K., Siva, K., Rayon-Estrada, V., Singbrant, S., Sommarin, M. N. E., Walkley, C. R., Soneji, S., Karlsson, G., Raya, Á., Sankaran, V. G. & Flygare, J., 2016 juni 14, I: Cell Reports. 15, 11, s. 2550-2562 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Lineages 100%
  • Fibroblast 50%
  • Murine 50%
  • Oncogene C Myc 50%
  • Differentiation 25%

• A network including TGFβ/Smad4, Gata2 and p57 regulates proliferation of mouse hematopoietic progenitor cells.

  Billing, M., Rörby, E., May, G., Tipping, A. J., Soneji, S., Brown, J., Salminen, M., Karlsson, G., Enver, T. & Karlsson, S., 2016, I: Experimental Hematology. 44, 5, s. 399-409

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Hematopoietic Stem Cell 100%
  • Transforming Growth Factor 100%
  • Hematopoietic Cell 28%
  • Gene 14%
  • Cell Function 14%
  254 Nedladdningar (Pure)
• 2015

  SCExV: a webtool for the analysis and visualisation of single cell qRT-PCR data.

  Lang, S., Ugale, A., Erlandsson, E., Karlsson, G., Bryder, D. & Soneji, S., 2015, I: BMC Bioinformatics. 16, 320.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Software 100%
  • Heterogeneous Population 100%
  211 Nedladdningar (Pure)