Amr Al-Haidari

Forskare, knuten till universitetet, Cancer Immunologist, PhD, Principle investigator

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Personlig profil

Forskning

Background

The tumor microenvironment (TME) has become one of the most intriguing topics in cancer research. The ability to manipulate the TME has shown promising results in the development of cancer therapeutics especially in the immunotherapy field. TME stromal cells display multifaceted anti and pro-carcinogenic roles underscoring the importance of manipulating the TME for developing effective therapy. Within the TME, exosomes are key players mediating communication across stromal cells and provide cancer cells with essential cues that promote the carcinogenesis and metastasis processes. Thus, understanding how exosomes regulate the TME would provide valuable insight into how primary tumors define the secondary tissues for subsequent cancer metastasis.

My research goal is to decipher the mechanism by which immune cells-derived exosomes mediate long distant communication with secondary tissues to promote premetastatic niche formation as a basis to develop cancer biomarkers and exosome-based targeted therapy to prevent metastasis. Two research theme areas in exosomes medical research are of major interest:


1. Cancer therapeutics
The role of exosomes in reprogramming distant organ’s stromal cells to form premetastatic niche as a basis to develop exosome-based targeted therapy in cancer to prevent metastasis.

2. Cancer biomarkers
The use of exosomes by means of liquid biopsy to develop tumor diagnostic and prognostic markers.

 

Current project: Exosomes as an MRD detection source in acute leukemias

Leukemia is a heterogeneous blood cancer characterized by multiple genetic and epigenetic aberrations resulting in the uncontrolled growth of immature myeloid or lymphoid cells. Despite the advances in leukemia therapy, the disease relapse is responsible for the vast majority of death cases among leukemic patients. Measurable residual disease (MRD) is considered as a gold standard clinical practice for the therapy decision-making process to achieve long-lasting remission based on the detection and quantification of pre and post-therapy-remaining leukemic blasts. However, relapse among negative MRD patients has been frequently reported highlighting the importance of other sensitive alternatives to detect MRD below the sensitivity of the existing MRD-detecting assays.

Exosomes have emerged as a novel non-invasive approach of liquid biopsy to diagnose and monitor patients allowing to bypass limitations posed by other conventional methods. These nano-scale particles feature selective markers inherited from their parental leukemic cells. The ability to immunophenotype leukemic cell-derived exosomes using multiparametric flow cytometry addresses an important question of whether they can be used for sensitive MRD detection. Therefore, translating this new diagnostic tool into clinical practice not only would revolutionize the detection of MRD in leukemic patients but also would offer a simple non-invasive method for sampling patients with hematological malignancies.

Student projects

Current student: Asyel Jabbar

Degree thesis: Bachelor's degree

Project title:  Validation of exosome’s yield and purity for clinical biomarkers discovery using polymer precipitation and size exclusion chromatography methods

Fingeravtryck

Utforska forskningsämnen där Amr Al-Haidari är aktiv. Dessa ämnesetiketter kommer från personens arbeten. Tillsammans bildar de ett unikt fingeravtryck.
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Nätverk

Externa samarbeten med länder/områden de senaste 5 åren