Personlig profil
Forskning
Dr. Charlotte Ling is a Professor at Lund University and a principle investigator of the Epigenetics and Diabetes Unit at Lund University Diabetes Centre (LUDC), Sweden. She obtained her PhD in Endocrinology at University of Gothenburg, Sweden in 2002. After a postdoc at Lund University, where she studied genetics of type 2 diabetes, she dedicated her research to the study of epigenetic mechanisms causing type 2 diabetes and metabolic disease. Her research group has over the last two decades pioneered the field of epigenetics in type 2 diabetes. They have made several groundbreaking discoveries such as genome-wide epigenetic modifications in pancreatic islets, skeletal muscle, adipose tissue and the liver from patients with type 2 diabetes compared with non-diabetic control subjects. Dr. Ling’s research group has also shown that genetic and non-genetic factors such as SNPs, exercise, diet, obesity and age alter the genome-wide epigenetic pattern in human primary tissues for type 2 diabetes. Dr. Ling is frequently invited to write review papers and book chapters and to give lectures (e.g. ADA, IDF, Keystone and Endocrine Society) on the topic ‘Epigenetics in Type 2 Diabetes’. She is still dissecting the impact of epigenetics in the pathogenesis of type 2 diabetes. More recently, she is trying to translate her epigenetic findings to biomarkers and novel therapies for precision medicine to improve prediction, prevention and treatments of type 2 diabetes.
Ämnesklassifikation (UKÄ)
- Medicinsk epigenetik och epigenomik
Fria nyckelord
- epigenetik
- muskel
- fettväv
- lever
- bukspottkörtel
- typ 2 diabetes
- DNA metylering
Expertis relaterad till FN:s globala mål
2015 godkände FN:s medlemsstater 17 Globala mål för en hållbar utveckling, för att utrota fattigdomen, skydda planeten och garantera välstånd för alla. Den här personens arbete relaterar till följande Globala mål:
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SDG 3 – God hälsa och välbefinnande
Fingeravtryck
- 1 Liknande profiler
Samarbeten under de senaste fem åren
Forskningsoutput
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Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes
Ofori, J. K., Ruhrmann, S., Lindström, A., Perfilyev, A., Martin, M., Karagiannopoulos, A., Scisciola, L., Kost, K., Jönsson, J., Nilsson, Å., Kantor, B., Rots, M. G., Dudenhöffer-Pfeifer, M., Wendt, A., Rönn, T., Eliasson, L., Bacos, K. & Ling, C., 2026 apr. 24, (E-pub ahead of print) I: Nature Metabolism.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
Öppen tillgång -
Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes
Sehgal, R., Haacke, N., Maguolo, A., Solari, F. A., Jähnert, M., Gottmann, P., Nilsson, E., Vaag, A., Fischer-Posovszky, P., Werberger, A., Birkenfeld, A. L., Fritsche, A., Häring, H. U., Sickmann, A., Vogel, H., Ling, C., Ouni, M. & Schürmann, A., 2025 dec., I: BMC Medicine. 23, 1, 678.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
Öppen tillgång -
Evaluating cell-specific gene expression using single-cell and single-nuclei RNA-sequencing data from human pancreatic islets of the same donors
Engström, K., Nilsson, Å., Ofori, J. K., Wierup, N., Bacos, K. & Ling, C., 2025 dec., I: Scientific Reports. 15, 1, 36133.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
Öppen tillgång -
Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood
Maguolo, A., Jönsson, J., Perfilyev, A., Vaag, A., Malchau Carlsen, E., Nørgaard, K., Franks, P. W., Renault, K. M. & Ling, C., 2025 dec., I: Clinical Epigenetics. 17, 1, 123.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
Öppen tillgång -
Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity
Heikkinen, A., Esser, V. F. C., Lee, S. H. T., Lundgren, S., Hakkarainen, A., Lundbom, J., Kuula, J., Groop, P. H., Heinonen, S., Villicaña, S., Bell, J. T., Maguolo, A., Nilsson, E., Ling, C., Vaag, A., Pajukanta, P., Kaprio, J., Pietiläinen, K. H., Li, S. & Ollikainen, M., 2025 dec., I: Nature Communications. 16, 1, 4374.Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
Öppen tillgång
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Farmakoepigenetik för precisionsmedicin inom typ 2 diabetes
Ling, C. (PI)
Swedish Government Agency for Innovation Systems (Vinnova)
2026/02/01 → 2029/01/31
Projekt: Forskning
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Do pharmacotherapy reverse type 2 diabetes-associated epigenetic modifications and thereby dysfunction in individual islet cells?
Ling, C. (PI)
2025/12/01 → 2026/11/30
Projekt: Forskning
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Epigenetic biomarker tools for prediction of response to treatment and complications in people with type 2 diabetes
Ling, C. (PI)
2025/11/01 → 2028/10/31
Projekt: Forskning
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Investigating the associations between diabetes mellitus, epigenetic biomarkers and bone complications
Vollmer, S. (Forskarstuderande), Ling, C. (Handledare), Maguolo, A. (Biträdande handledare), Fagher, K. (Biträdande handledare), García-Calzón, S. (Biträdande handledare), Lindström, A. (Forskare) & Maurin, L. (Forskare)
2025/02/01 → …
Projekt: Avhandling
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Blood-based epigenetic biomarkers for prediction of macrovascular events in individuals with type 2 diabetes
Ling, C. (PI)
2025/01/01 → 2027/12/31
Projekt: Forskning
Aktiviteter
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chair of review panel in medicine
Ling, C. (ordförande)
2021Aktivitet: Konsultverksamhet, expertuppdrag och medlemskap › Sakkunnig/expert i peer review-panel eller kommitté (ej publikationer)
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Epigenomic signatures of type 2 diabetes
Ling, C. (Inbjuden talare)
2021Aktivitet: Föredrag eller presentation › Inbjuden talare
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Epigenetic and metabolic abnormalities in type 2 diabetes
Ling, C. (Inbjuden talare)
2021Aktivitet: Föredrag eller presentation › Inbjuden talare
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Type 2 diabetes and epigenetic alterations in human pancreatic islets
Ling, C. (Inbjuden talare)
2019Aktivitet: Föredrag eller presentation › Inbjuden talare
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Epigenetic mechanisms in human obesity and type 2 diabetes
Ling, C. (Inbjuden talare)
2019Aktivitet: Föredrag eller presentation › Inbjuden talare
Priser och utmärkelser
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Distinguished professor award
Ling, C. (Mottagare), 2021
Pris: Pris (inklusive medaljer och utmärkelser)
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Novo Nordisk Distinguished Investigator Grant in Endocrinology and metabolism, Five-year
Ling, C. (Mottagare), 2021
Pris: Pris (inklusive medaljer och utmärkelser)
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The DPLU/LUDC Nordic Prize for an Outstanding Young Diabetes Investigator, Sweden
Ling, C. (Mottagare), 2016
Pris: Pris (inklusive medaljer och utmärkelser)
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Medeon award, Medeon Science Park, Sweden
Ling, C. (Mottagare), 2013
Pris: Pris (inklusive medaljer och utmärkelser)