Deniz Kirik

Sökresultat

• 2022

  A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells

  Moriarty, N., Gantner, C. W., Hunt, C. P. J., Ermine, C. M., Frausin, S., Viventi, S., Ovchinnikov, D. A., Kirik, D., Parish, C. L. & Thompson, L. H., 2022 mars 3, I: Cell Stem Cell. 29, 3, s. 434-448.e5

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Pluripotent Stem Cells 100%
  • Mesencephalon 88%
  • Cell- and Tissue-Based Therapy 81%
  • Genetic Therapy 79%
  • Dopamine 72%

• Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks

  Marciano, S., Ionescu, T. M., Saw, R. S., Cheong, R. Y., Kirik, D., Maurer, A., Pichler, B. J. & Herfert, K., 2022 okt. 4, I: Proceedings of the National Academy of Sciences of the United States of America. 119, 40, e2122552119.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Neuroimaging 79%
  • Brain 42%
  • Genes 35%
  • Gene Editing 30%

• High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping

  Frantz, D., Karamahmutoglu, T., Schaser, A. J., Kirik, D. & Berrocal, E., 2022 sep. 1, I: Biomedical Optics Express. 13, 9, s. 4907-4925 19 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Lighting 100%
  • Microscopy 75%
  • illumination 68%
  • microscopy 62%
  • Light 49%

• Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats

  Tugba, E. K., Medine, G. I. O., Ozlem, A., Deniz, K. & Filiz, O. Y., 2022, I: Pharmacology Biochemistry and Behavior. 213, 173317.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Absence Epilepsy 100%
  • Serotonin 78%
  • Synaptic Transmission 66%
  • Seizures 54%
  • Dopamine 22%
• 2021

  Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease

  Huynh, B., Fu, Y., Kirik, D., Shine, J. M. & Halliday, G. M., 2021, I: Movement Disorders. 36, 9, s. 2085-2093

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Locus Coeruleus 100%
  • Substantia Nigra 89%
  • Prosencephalon 89%
  • Parkinson Disease 69%
  • Adrenergic Neurons 54%

• DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease

  Arkan, S., Ljungberg, M., Kirik, D. & Hansen, C., 2021 okt., I: Neurobiology of Disease. 158, 105477.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleinopathies 100%
  • Pars Compacta 69%
  • Parkinson Disease 59%
  • Animal Models 51%
  • Cell Death 40%

• Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model

  Cheong, R. Y., Baldo, B., Sajjad, M. U., Kirik, D. & Petersén, Å., 2021 juni 1, I: Neuropathology and Applied Neurobiology. 47, 4, s. 564-578 15 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Huntington Disease 100%
  • Body Weight Changes 54%
  • Corpus Striatum 43%
  • Central Nervous System 33%
  • Adenosine A2A Receptors 31%

• Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome

  Petty, A., Cui, X., Ali, A., Du, Z., Srivastav, S., Kesby, J. P., Kirik, D., Howes, O. & Eyles, D., 2021, I: Scientific Reports. 11, 1, 4294.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Schizophrenia 100%
  • Animal Models 88%
  • Phenotype 73%
  • Dopamine 64%
  • Animals 61%

• Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease

  Marmion, D. J., Rutkowski, A. A., Chatterjee, D., Hiller, B. M., Werner, M. H., Bezard, E., Kirik, D., McCown, T., Gray, S. J. & Kordower, J. H., 2021, I: Neurobiology of Disease. 148, 105184.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Multiple System Atrophy 100%
  • alpha-Synuclein 72%
  • Primates 70%
  • Rodentia 62%
  • Inclusion Bodies 26%
• 2020

  Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

  Landeck, N., Strathearn, K. E., Ysselstein, D., Buck, K., Dutta, S., Banerjee, S., Lv, Z., Hulleman, J. D., Hindupur, J., Lin, L. K., Padalkar, S., Stanciu, L. A., Lyubchenko, Y. L., Kirik, D. & Rochet, J. C., 2020, I: Molecular Neurodegeneration. 15, 1, 49.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • Synucleinopathies 20%
  • Parkinson Disease 18%
  • Membranes 17%
  • Dopaminergic Neurons 15%

• Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

  Gantner, C. W., de Luzy, I. R., Kauhausen, J. A., Moriarty, N., Niclis, J. C., Bye, C. R., Penna, V., Hunt, C. P. J., Ermine, C. M., Pouton, C. W., Kirik, D., Thompson, L. H. & Parish, C. L., 2020, I: Cell Stem Cell. 26, 4, s. 511-526.e5

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Glial Cell Line-Derived Neurotrophic Factor 100%
  • Parkinson Disease 63%
  • Stem Cells 55%
  • Pluripotent Stem Cells 53%
  • Dopaminergic Neurons 47%
• 2019

  Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia

  Petty, A., Cui, X., Tesiram, Y., Kirik, D., Howes, O. & Eyles, D., 2019, I: npj Schizophrenia. 5, 1, 6.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Dopamine 100%
  • Schizophrenia 96%
  • Animal Models 85%
  • Amphetamine 43%
  • GTP Cyclohydrolase 20%

• Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

  Elfarrash, S., Jensen, N. M., Ferreira, N., Betzer, C., Thevathasan, J. V., Diekmann, R., Adel, M., Omar, N. M., Boraie, M. Z., Gad, S., Ries, J., Kirik, D., Nabavi, S. & Jensen, P. H., 2019, I: Acta Neuropathologica Communications. 7, 1, 213.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • alpha-Synuclein 79%
  • Serine 21%
  • Microinjections 16%
  • Synucleinopathies 10%

• SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease

  Baldo, B., Gabery, S., Soylu-Kucharz, R., Cheong, R. Y., Henningsen, J. B., Englund, E., McLean, C., Kirik, D., Halliday, G. & Petersén, 2019, I: Neuropathology and Applied Neurobiology. 45, 4, s. 361-379

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Huntington Disease 100%
  • Metabolic Networks and Pathways 90%
  • Brain 44%
  • Orexins 43%
  • Lateral Hypothalamic Area 42%
• 2018

  In vivo quantification of glial activation in minipigs overexpressing human α-synuclein

  Lillethorup, T. P., Glud, A. N., Landeck, N., Alstrup, A. K. O., Jakobsen, S., Vang, K., Doudet, D. J., Brooks, D. J., Kirik, D., Hinz, R., Sørensen, J. C. & Landau, A. M., 2018, I: Synapse. 72, 12, e22060.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Miniature Swine 88%
  • Substantia Nigra 70%
  • Neuroglia 58%
  • Dependovirus 48%

• Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs

  Lillethorup, T. P., Glud, A. N., Alstrup, A. K. O., Noer, O., Nielsen, E. H. T., Schacht, A. C., Landeck, N., Kirik, D., Orlowski, D., Sørensen, J. C. H., Doudet, D. J. & Landau, A. M., 2018, I: Scientific Reports. 8, 1, 15715.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Miniature Swine 100%
  • 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile 89%
  • (R)-(11C)1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide 86%
  • Proteasome Endopeptidase Complex 77%
  • lactacystin 74%

• Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice

  Hansen, M. G., Ledri, L. N., Kirik, D., Kokaia, M. & Ledri, M., 2018 jan. 9, I: Frontiers in Cellular Neuroscience. 11, 433.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Parvalbumins 100%
  • Synapses 71%
  • gamma-Aminobutyric Acid 37%
  • Seizures 30%
  • Optogenetics 25%

• Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay

  Baldo, B., Sajjad, M. U., Cheong, R. Y., Bigarreau, J., Vijayvargia, R., McLean, C., Perrier, A. L., Seong, I. S., Halliday, G., Petersén, Å. & Kirik, D., 2018, I: eNeuro. 5, 4

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Huntingtin Protein 100%
  • Mutant Proteins 73%
  • Huntington Disease 31%
  • polyglutamine 30%
  • Induced Pluripotent Stem Cells 6%
• 2017

  Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats

  Naughton, C., O'Toole, D., Kirik, D. & Dowd, E., 2017 jan. 1, I: Behavioural Brain Research. 316, s. 160-168 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Rotenone 87%
  • Pesticides 73%
  • Parkinson Disease 55%
  • Genes 26%

• Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

  Mandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J. & Kordower, J. H., 2017 juni 16, I: Acta Neuropathologica Communications. 5, 1, s. 47

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Multiple System Atrophy 100%
  • alpha-Synuclein 90%
  • Primates 70%
  • Rodentia 62%
  • Oligodendroglia 55%

• Toxic effects of human and rodent variants of alpha-synuclein in vivo

  Landeck, N., Buck, K. & Kirik, D., 2017 feb. 1, I: European Journal of Neuroscience. 45, 4, s. 536-547 12 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • alpha-Synuclein 100%
  • human SNCB protein 93%
  • Rodentia 69%
  • Poisons 61%
  • rat Snca protein 40%
• 2016

  A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein

  Landeck, N., Hall, H., Ardah, M. T., Majbour, N. K., El-Agnaf, O. M. A., Halliday, G. & Kirik, D., 2016 aug. 22, I: Molecular Neurodegeneration. 11, 1, 125.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • human SNCA protein 100%
  • alpha-Synuclein 75%
  • Parkinson Disease 30%
  • human PLK2 protein 21%
  • Post Translational Protein Processing 18%

• Assessment of brain metabolite correlates of AAV-mediated overexpression of human alpha-synuclein in cortical neurons by in vivo(1) H-MR spectroscopy at 9.4 T.

  Cuellar-Baena, S., Landeck, N., Sonnay, S., Buck, K., Mlynarik, V., in 't Zandt, R. & Kirik, D., 2016, I: Journal of Neurochemistry. 137, 5, s. 806-819

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • human SNCA protein 100%
  • Ascorbate 70%
  • Lactic Acid 56%
  • Magnetic Resonance Spectroscopy 53%
  • 1H NMR Spectroscopy 52%
• 2015

  A doctor's dilemma

  Kirik, D. & Pain, E., 2015 nov. 20, I: Science (New York, N.Y.). 350, 6263, s. 998

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

  • Sweden 100%
  • Genetic Therapy 94%
  • Career Choice 72%
  • Neurosciences 54%
  • Turkey 54%

• Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.

  Cederfjäll, E., Broom, L. & Kirik, D., 2015, I: Molecular Therapy. 23, 5, s. 896-906

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • GTP Cyclohydrolase 100%
  • Gene Transfer Techniques 81%
  • Dihydrofolates 80%
  • Tetrahydrofolate Dehydrogenase 63%
  • Corpus Striatum 61%
  159 Nedladdningar (Pure)

• Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.

  Soylu, R., Adlesic, N., Baldo, B., Kirik, D. & Petersén, Å., 2015, I: Scientific Reports. 5, 14598.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Brown Adipose Tissue 100%
  • Hypothalamus 75%
  • Huntington Disease 60%
  • Zona Incerta 41%
  • Neuropeptide Receptors 40%
  235 Nedladdningar (Pure)

• Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.

  Kuzdas-Wood, D., Fellner, L., Premstaller, M., Borm, C., Bloem, B., Kirik, D., Wenning, G. K. & Stefanova, N., 2015, I: BMC Neuroscience. 16, 1, 86.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • Multiple System Atrophy 87%
  • Oligodendroglia 72%
  • Corpus Striatum 64%
  • Quinolinic Acid 31%

• Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.

  Buck, K., Landeck, N., Ulusoy, A., Majbour, N. K., El-Agnaf, O. M. A. & Kirik, D., 2015, I: Neurobiology of Disease. 78, Mar 25, s. 100-114

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Substantia Nigra 70%
  • Dopaminergic Neurons 69%
  • Phosphotransferases 51%
  • Phosphorylation 45%

• Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.

  Gabery, S., Georgiou-Karistianis, N., Hult Lundh, S., Cheong, R., Churchyard, A., Chua, P., Stout, J. C., Egan, G. F., Kirik, D. & Petersén, Å., 2015, I: PLoS ONE. 10, 2, e0117593.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • Huntington Disease 100%
  • Hypothalamus 83%
  • Magnetic Resonance Imaging 59%
  • Sleep 17%
  • Emotional Regulation 13%
  412 Nedladdningar (Pure)
• 2014

  Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease.

  Sahin, G., Thompson, L., Lavisse, S., Özgür, M., Rbah-Vidal, L., Dollé, F., Hantraye, P. & Kirik, D., 2014, I: PLoS ONE. 9, 3, e90759.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Dopamine Receptors 100%
  • Dyskinesias 97%
  • Dopamine 74%
  • Parkinson Disease 74%
  • Corpus Striatum 21%
  183 Nedladdningar (Pure)

• Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

  Ledri, M., Grönning Madsen, M., Nikitidou, L., Kirik, D. & Kokaia, M., 2014, I: Journal of Neuroscience. 34, 9, s. 3364-3377

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Optogenetics 100%
  • Interneurons 81%
  • Light 31%
  • Action Potentials 19%
  • Epilepsy 18%
  244 Nedladdningar (Pure)

• Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease

  Moloney, T. C., Hyland, R., O'Toole, D., Paucard, A., Kirik, D., O'Doherty, A., Gorman, A. M. & Dowd, E., 2014, I: CNS Neuroscience & Therapeutics. 20, 1, s. 50-58

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Synucleins 100%
  • Dependovirus 81%
  • HSP70 Heat-Shock Proteins 80%
  • alpha-Synuclein 79%
  • Viral Genes 77%

• Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.

  Hall, H., Reyes, S., Landeck, N., Bye, C., Leanza, G., Double, K., Thompson, L., Halliday, G. & Kirik, D., 2014, I: Brain. 137, Jul 24, s. 2493-2508

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Cholinergic Agents 100%
  • Parkinson Disease 89%
  • Dementia 89%
  • Pathology 67%
  • Synucleins 58%

• Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

  Berglind, F., Ledri, M., Sørensen, A. T., Nikitidou, L., Melis, M., Bielefeld, P., Kirik, D., Deisseroth, K., Andersson, M. & Kokaia, M., 2014, I: Neurobiology of Disease. 65, s. 133-141

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Optogenetics 100%
  • Seizures 59%
  • Epilepsy 48%
  • Hippocampus 30%
  • Neurons 23%
  589 Nedladdningar (Pure)
• 2013

  Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration

  Xilouri, M., Brekk, O. R., Landeck, N., Pitychoutis, P. M., Papasilekas, T., Papadopoulou-Daifoti, Z., Kirik, D. & Stefanis, L., 2013, I: Brain. 136, s. 2130-2146

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Chaperone-Mediated Autophagy 100%
  • alpha-Synuclein 71%
  • Substantia Nigra 17%
  • Lysosome-Associated Membrane Glycoproteins 16%
  • Parkinson Disease 9%

• Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors.

  Hall, H., Jewett, M., Landeck, N., Nilsson, N., Schagerlöf, U., Leanza, G. & Kirik, D., 2013, I: PLoS ONE. 8, 5, e64844.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • human SNCA protein 100%
  • Ventral Tegmental Area 77%
  • Cholinergic Agents 59%
  • Dopaminergic Neurons 49%
  • Parkinson Disease 39%
  169 Nedladdningar (Pure)

• Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

  Cederfjäll, E., Nilsson, N., Sahin, G., Chu, Y., Nikitidou, E., Björklund, T., Kordower, J. H. & Kirik, D., 2013, I: Scientific Reports. 3, 2157.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

  • GTP Cyclohydrolase 100%
  • Tyrosine 3-Monooxygenase 69%
  • Parkinson Disease 53%
  • Primates 16%
  • Behavior Rating Scale 10%
  189 Nedladdningar (Pure)

• Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntingtons disease

  Hult Lundh, S., Nilsson, N., Soylu, R., Kirik, D. & Petersén, Å., 2013, I: Human Molecular Genetics. 22, 17, s. 3485-3497

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • Huntington Disease 100%
  • Transgenic Mice 80%
  • Anxiety 40%
  • Depression 29%
  • Psychiatry 25%
  217 Nedladdningar (Pure)

• Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

  Febbraro, F., Sahin, G., Farran, A., Soares, S., Jensen, P. H., Kirik, D. & Romero-Ramos, M., 2013, I: Neurobiology of Disease. 56, s. 47-58

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • alpha-Synuclein 100%
  • Parkinson Disease 69%
  • Pathology 52%
  • Serine 37%
  • Phosphorylation 15%

• The behavioural and neuropathological impact of intranigral AAV-alpha-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats

  Mulcahy, P., O'Doherty, A., Paucard, A., O'Brien, T., Kirik, D. & Dowd, E., 2013, I: Behavioural Brain Research. 243, s. 6-15

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Rotenone 100%
  • alpha-Synuclein 90%
  • Pesticides 83%
  • Parkinson Disease 63%
  • Synucleinopathies 35%

• Transduced Wild-Type but Not P301S Mutated Human Tau Shows Hyperphosphorylation in Transgenic Mice Overexpressing A30P Mutated Human Alpha-Synuclein

  Oksman, M., Wisman, L., Jiang, H., Miettinen, P., Kirik, D. & Tanila, H., 2013, I: Neurodegenerative Diseases. 12, 2, s. 91-102

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • human SNCA protein 100%
  • Transgenic Mice 56%
  • Neurons 22%
  • Spatial Memory 19%
  • Synucleinopathies 12%

• Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

  Reyes, S., Fu, Y., Double, K. L., Cottam, V., Thompson, L. H., Kirik, D., Paxinos, G., Watson, C., Cooper, H. M. & Halliday, G. M., 2013, I: Neurobiology of Aging. 34, 3, s. 873-886

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • homeobox protein PITX3 100%
  • Dopaminergic Neurons 82%
  • Homeobox Genes 73%
  • Parkinson Disease 66%
  • Colorectal Neoplasms 62%

• Variability in Neuronal Expression of Dopamine Receptors and Transporters in the Substantia Nigra

  Reyes, S., Cottam, V., Kirik, D., Double, K. L. & Halliday, G. M., 2013, I: Movement Disorders. 28, 10, s. 1351-1359

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Dopamine Plasma Membrane Transport Proteins 100%
  • Dopamine Receptors 91%
  • Substantia Nigra 87%
  • Mesencephalon 84%
  • Dopaminergic Neurons 60%
• 2012

  alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

  Lastres-Becker, I., Ulusoy, A., Innamorato, N. G., Sahin, G., Rabano, A., Kirik, D. & Cuadrado, A., 2012, I: Human Molecular Genetics. 21, 14, s. 3173-3192

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • alpha-Synuclein 100%
  • Parkinson Disease 69%
  • Inflammation 49%
  • Heme Oxygenase-1 39%
  • Dopaminergic Neurons 34%
  244 Nedladdningar (Pure)

• Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.

  Ledri, M., Nikitidou, L., Erdelyi, F., Szabo, G., Kirik, D., Deisseroth, K. & Kokaia, M., 2012, I: European Journal of Neuroscience. 36, 1, s. 1971-1983

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Optogenetics 100%
  • Dentate Gyrus 84%
  • Synapses 70%
  • Neuropeptide Y 49%
  • Hippocampus 27%

• Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.

  Gabery, S., Sajjad, M. U., Hult Lundh, S., Soylu, R., Kirik, D. & Petersén, Å., 2012, I: European Journal of Neuroscience. 36, 6, s. 2789-2800

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Huntington Disease 100%
  • Prosencephalon 96%
  • Cerebral Cortex 83%
  • Serogroup 82%
  • Green Fluorescent Proteins 64%

• Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.

  Cederfjäll, E., Sahin, G., Kirik, D. & Björklund, T., 2012, I: Molecular Therapy. 20, 7, s. 1315-1326

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Fil

  • GTP Cyclohydrolase 100%
  • Dihydroxyphenylalanine 82%
  • Tyrosine 3-Monooxygenase 69%
  • Tyrosine 58%
  • Parkinson Disease 53%
  159 Nedladdningar (Pure)

• Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.

  Mulcahy, P., O'Doherty, A., Paucard, A., O'Brien, T., Kirik, D. & Dowd, E., 2012, I: Neuroscience. 203, s. 170-179

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synucleins 100%
  • Rotenone 87%
  • alpha-Synuclein 79%
  • Pesticides 73%
  • Parkinson Disease 55%

• Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue.

  Hall, H., Cuellar-Baena, S., Denisov, V. & Kirik, D., 2012, I: Journal of Neurochemistry.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Choline O-Acetyltransferase 100%
  • Choline 87%
  • Acetylcholine 86%
  • Magnetic Resonance Spectroscopy 68%
  • NMR Spectroscopy 54%

• Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons

  Ulusoy, A., Björklund, T., Buck, K. & Kirik, D., 2012, I: Neurobiology of Disease. 47, 3, s. 367-377

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • alpha-Synuclein 100%
  • Substantia Nigra 89%
  • Dopamine 70%
  • Dopaminergic Neurons 62%
  • Neurons 51%