Herwig Schüler

Sökresultat

• 2024

  A multidomain PARP14 construct suitable for bacterial expression

  Chatzicharalampous, C. & Schüler, H., 2024 aug. 19, I: Protein Expression and Purification. 224, 8 s., 106580.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Poly ADP Ribose Polymerase 100%
  • Protein 66%
  • Enzyme 16%
  • In Vitro Study 16%
  • Nucleic Acid 16%

• PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype

  Sturniolo, I., Váróczy, C., Regdon, Z., Mázló, A., Muzsai, S., Bácsi, A., Intili, G., Hegedűs, C., Boothby, M. R., Holechek, J., Ferraris, D., Schüler, H. & Virág, L., 2024 apr., I: International Journal of Molecular Sciences. 25, 7, 3601.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Phenotype 100%
  • Macrophage 100%
  • Polarization 28%
  • Anticancer 28%
  • Poly ADP Ribose Polymerase 28%
• 2023

  PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities

  Đukić, N., Strømland, Ø., Elsborg, J. D., Munnur, D., Zhu, K., Schuller, M., Chatrin, C., Kar, P., Duma, L., Suyari, O., Rack, J. G. M., Baretić, D., Crudgington, D. R. K., Groslambert, J., Fowler, G., Wijngaarden, S., Prokhorova, E., Rehwinkel, J., Schüler, H. & Filippov, D. V. & 5 andra, Sanyal, S., Ahel, D., Nielsen, M. L., Smith, R. & Ahel, I., 2023 sep. 15, I: Science Advances. 9, 37, 18 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Poly ADP Ribose Polymerase 100%
  • Transferase 100%
  • Macrodomain 100%
  • Protein 40%
  • Immunity 33%

• PARP14 is a writer, reader, and eraser of mono-ADP-ribosylation

  Torretta, A., Chatzicharalampous, C., Ebenwaldner, C. & Schüler, H., 2023 juli 26, I: The Journal of biological chemistry. 299, 9, 105096.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Mono Adenosine Diphosphate Ribosylation 100%
  • Macrodomain 100%
  • Adenosine Diphosphate Ribose 14%

• Combining pharmacophore models derived from DNA-encoded chemical libraries with structure-based exploration to predict Tankyrase 1 inhibitors

  Montoya, A. L., Glavatskikh, M., Halverson, B. J., Yuen, L. H., Schüler, H., Kireev, D. & Franzini, R. M., 2023 jan. 15, I: European Journal of Medicinal Chemistry. 246, s. 114980 16 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Inhibitor 100%
  • Deoxyribonucleic Acid 100%
  • Ligand 40%
  • Electron Affinity 20%
  • IC50 20%
• 2022

  14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation

  Ebenwaldner, C., Hornyak, P., García-Saura, A. G., Torretta, A., Anoosheh, S., Hofer, A. & Schüler, H., 2022 dec., I: Pathogens. 11, 12, 1497.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Protein 100%
  • SH2 Domain 100%
  • Actin 100%
  • Exoenzyme 100%
  • Cladistics 16%
• 2021

  System-wide identification and prioritization of enzyme substrates by thermal analysis

  Saei, A. A., Beusch, C. M., Sabatier, P., Wells, J. A., Gharibi, H., Meng, Z., Chernobrovkin, A., Rodin, S., Näreoja, K., Thorsell, A.-G., Karlberg, T., Cheng, Q., Lundström, S. L., Gaetani, M., Végvári, Á., Arnér, E. S. J., Schüler, H. & Zubarev, R. A., 2021 feb. 26, I: Nature Communications. 12, 1, 13 s., 1296.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Drug Discovery 100%
  • Thioredoxin Reductase 1 100%
  • Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 100%
  • Diseases 100%
  • Thermostability 100%

• MacroGreen, a simple tool for detection of ADP-ribosylated proteins

  García-Saura, A. G., Herzog, L. K., Dantuma, N. P. & Schüler, H., 2021, I: Communications Biology. 4, 1, 919.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

• PARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis

  García-Saura, A. G. & Schüler, H., 2021, I: Cells. 10, 3

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Histone 100%
  • Urea 100%
  • Poly ADP Ribose Polymerase 100%
  • Species 25%
  • Regulatory Mechanism 25%
• 2020

  Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

  Nowak, K., Rosenthal, F., Karlberg, T., Bütepage, M., Thorsell, A.-G., Dreier, B., Grossmann, J., Sobek, J., Imhof, R., Lüscher, B., Schüler, H., Plückthun, A., Leslie Pedrioli, D. M. & Hottiger, M. O., 2020 okt. 15, I: Nature Communications. 11, 1, 14 s., 5199.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Adenosine Diphosphate Ribose 100%
  • Adenosine Diphosphate 100%
  • ADP-ribosylation 75%
  • Protein Tertiary Structure 33%
  • Binding Affinity 33%
• 2019

  A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD⁺-Dependent Enzymes

  Yuen, L. H., Dana, S., Liu, Y., Bloom, S. I., Thorsell, A.-G., Neri, D., Donato, A. J., Kireev, D., Schüler, H. & Franzini, R. M., 2019 apr. 3, I: Journal of the American Chemical Society. 141, 13, s. 5169-5181 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Enzyme 100%
  • Chemical Library 100%
  • Protein Ligand 33%
  • Adenosine Diphosphate 33%
• 2018

  A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity

  Kirby, I. T., Kojic, A., Arnold, M. R., Thorsell, A.-G., Karlberg, T., Vermehren-Schmaedick, A., Sreenivasan, R., Schultz, C., Schüler, H. & Cohen, M. S., 2018 dec. 20, I: Cell Chemical Biology. 25, 12, s. 1547-1553.e12

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Subcellular Localization 100%
  • Poly ADP Ribose Polymerase 100%
  • Enzymatic Activity 100%
  • Mono Adenosine Diphosphate Ribosylation 50%
  • Nuclear Membrane 25%

• 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

  Karlberg, T., Hornyak, P., Pinto, A. F., Milanova, S., Ebrahimi, M., Lindberg, M., Püllen, N., Nordström, A., Löverli, E., Caraballo, R., Wong, E. V., Näreoja, K., Thorsell, A.-G., Elofsson, M., De La Cruz, E. M., Björkegren, C. & Schüler, H., 2018 sep. 17, I: Nature Communications. 9, 1, 3785.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Pseudomonas 100%
  • 14-3-3 Protein 100%
  • Phosphopeptide 25%
  • Vibrio 25%

• A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

  Favalli, N., Biendl, S., Hartmann, M., Piazzi, J., Sladojevich, F., Gräslund, S., Brown, P. J., Näreoja, K., Schüler, H., Scheuermann, J., Franzini, R. & Neri, D., 2018 juli 6, I: ChemMedChem. 13, 13, s. 1303-1307 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • DNA A 100%
  • Lysine 100%
  • Tankyrase 50%
  • 4 Aminomethylbenzoic Acid 50%
  • Dextro Lysine 50%

• Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14

  Holechek, J., Lease, R., Thorsell, A.-G., Karlberg, T., McCadden, C., Grant, R., Keen, A., Callahan, E., Schüler, H. & Ferraris, D., 2018 juni 15, I: Bioorganic & Medicinal Chemistry Letters. 28, 11, s. 2050-2054 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Transferase 100%
  • Adenosine Diphosphate 100%
  • Structure Activity Relation 50%
  • PARP1 50%
  • Poly ADP Ribose Polymerase 50%

• Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

  Ekblad, T., Verheugd, P., Lindgren, A. E., Nyman, T., Elofsson, M. & Schüler, H., 2018 apr., I: SLAS Discovery. 23, 4, s. 353-362 10 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Surface Plasmon Resonance 100%
  • Mono Adenosine Diphosphate Ribosylation 77%
  • Concentration Response 33%

• Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity

  Saleeb, M., Sundin, C., Aglar, Ö., Pinto, A. F., Ebrahimi, M., Forsberg, Å., Schüler, H. & Elofsson, M., 2018 jan. 1, I: European Journal of Medicinal Chemistry. 143, s. 568-576 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Structure Activity Relationship 100%
  • Exoenzyme S 100%
  • Adenosine Diphosphate 100%
  • Pseudomonas aeruginosa 100%
  • Structure Activity Relation 100%
• 2017

  Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14

  Upton, K., Meyers, M., Thorsell, A.-G., Karlberg, T., Holechek, J., Lease, R., Schey, G., Wolf, E., Lucente, A., Schüler, H. & Ferraris, D., 2017 juli 1, I: Bioorganic & Medicinal Chemistry Letters. 27, 13, s. 2907-2911 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Transferase 100%
  • Adenosine Diphosphate 100%

• Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors

  Thorsell, A.-G., Ekblad, T., Karlberg, T., Löw, M., Pinto, A. F., Trésaugues, L., Moche, M., Cohen, M. S. & Schüler, H., 2017 feb. 23, I: Journal of Medicinal Chemistry. 60, 4, s. 1262-1271 10 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Tankyrase Inhibitor 100%
  • Rucaparib 20%
  • 7,8 Dihydro 2 [4 (Trifluoromethyl)phenyl] 5h thiopyrano[4,3 D]pyrimidin 4 Ol 20%
  • Talazoparib 20%
  • Olaparib 20%

• Small Molecule Microarray Based Discovery of PARP14 Inhibitors

  Peng, B., Thorsell, A.-G., Karlberg, T., Schüler, H. & Yao, S. Q., 2017 jan. 2, I: Angewandte Chemie (International edition). 56, 1, s. 248-253 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 100%
  • Neoplasm 50%
  • Structure Activity Relationship 50%
  • Cellular Processes 50%
  • Crystallization 50%
• 2016

  Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity

  Pinto, A. F., Ebrahimi, M., Saleeb, M., Forsberg, Å., Elofsson, M. & Schüler, H., 2016 juli, I: Journal of Biomolecular Screening. 21, 6, s. 590-5 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Pseudomonas aeruginosa 100%
  • Exotoxin 100%
  • Dinucleotide 50%

• Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis

  Kouznetsova, E., Kanno, T., Karlberg, T., Thorsell, A.-G., Wisniewska, M., Kursula, P., Sjögren, C. & Schüler, H., 2016 maj 3, I: Structure. 24, 5, s. 789-796 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Glutamic Acid 100%
  • Protein Complexes 100%
  • Chromosome Segregation 100%
  • Acetyl-CoA 100%
  • SMC3 100%

• DNA binding to SMC ATPases-trapped for release

  Schüler, H. & Sjögren, C., 2016 apr. 1, I: EMBO Journal. 35, 7, s. 703-5 3 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Rad50 100%
  • DNA Binding Site 33%

• Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres

  Ekblad, T. & Schüler, H., 2016 mars, I: Chemical Biology and Drug Design. 87, 3, s. 478-82 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Sirtuin 100%
  • Nicotinamide 100%
  • Bioisostere 100%
  • Poly ADP Ribose Polymerase 100%
  • Adenosine Diphosphate 33%
• 2015

  Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

  Samain, F., Ekblad, T., Mikutis, G., Zhong, N., Zimmermann, M., Nauer, A., Bajic, D., Decurtins, W., Scheuermann, J., Brown, P. J., Hall, J., Gräslund, S., Schüler, H., Neri, D. & Franzini, R. M., 2015 juni 25, I: Journal of Medicinal Chemistry. 58, 12, s. 5143-9 7 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Tankyrase 100%
  • Carboxylic Acid 50%
  • Poly(ADPribose) 50%
  • IC50 33%
  • Carboxylate 33%

• Towards small molecule inhibitors of mono-ADP-ribosyltransferases

  Ekblad, T., Lindgren, A. E. G., Andersson, C. D., Caraballo, R., Thorsell, A.-G., Karlberg, T., Spjut, S., Linusson, A., Schüler, H. & Elofsson, M., 2015 maj 5, I: European Journal of Medicinal Chemistry. 95, s. 546-51 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Diphtheria Toxin 100%
  • Cancer Drug Development 50%

• Pivotal and distinct role for Plasmodium actin capping protein alpha during blood infection of the malaria parasite

  Ganter, M., Rizopoulos, Z., Schüler, H. & Matuschewski, K., 2015 apr., I: Molecular Microbiology. 96, 1, s. 84-94 11 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Capping Phenomenon 100%
  • Actin Capping 100%
  • Beta Chain 30%
  • Protein Subunit 20%
  • Alpha Chain 20%

• Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library

  Franzini, R. M., Ekblad, T., Zhong, N., Wichert, M., Decurtins, W., Nauer, A., Zimmermann, M., Samain, F., Scheuermann, J., Brown, P. J., Hall, J., Gräslund, S., Schüler, H. & Neri, D., 2015 mars 23, I: Angewandte Chemie (International edition). 54, 13, s. 3927-31 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Small Molecule 100%
  • Structure Activity Relation 100%
  • DNA Sequence 100%
  • Binding Affinity 100%
  • Enzyme Inhibition 100%

• Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein

  Karlberg, T., Klepsch, M., Thorsell, A.-G., Andersson, C. D., Linusson, A. & Schüler, H., 2015 mars 20, I: The Journal of biological chemistry. 290, 12, s. 7336-44 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Polymerase 100%
  • Adenosine Diphosphate 100%
  • Zinc Finger Protein 100%
  • Antiviral Protein 100%
  • Poly ADP Ribose Polymerase 71%
• 2014

  Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors

  Liscio, P., Carotti, A., Asciutti, S., Karlberg, T., Bellocchi, D., Llacuna, L., Macchiarulo, A., Aaronson, S. A., Schüler, H., Pellicciari, R. & Camaioni, E., 2014 mars 27, I: Journal of Medicinal Chemistry. 57, 6, s. 2807-12 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Tankyrase Inhibitor 100%
  • Phenol 33%
• 2013

  Chemical probes to study ADP-ribosylation: Synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3

  Lindgren, A. E. G., Karlberg, T., Ekblad, T., Spjut, S., Thorsell, A.-G., Andersson, C. D., Nhan, T. T., Hellsten, V., Weigelt, J., Linusson, A., Schüler, H. & Elofsson, M., 2013 dec. 12, I: Journal of Medicinal Chemistry. 56, 23, s. 9556-68 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Ribosylation 100%
  • Ammonium Dihydrogen Phosphate 100%
  • Adenosine Diphosphate 100%
  • Stereochemistry 33%
  • Ethylene 33%

• PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3

  Lindgren, A. E. G., Karlberg, T., Thorsell, A.-G., Hesse, M., Spjut, S., Ekblad, T., Andersson, C. D., Pinto, A. F., Weigelt, J., Hottiger, M. O., Linusson, A., Elofsson, M. & Schüler, H., 2013 aug. 16, I: ACS Chemical Biology. 8, 8, s. 1698-703 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Poly ADP Ribose Polymerase 100%
  • Adenosine Diphosphate 100%
  • Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor 100%
  • PARP Inhibitor 100%
  • Polymerase 50%

• Pharmacology of ADP-ribosylation

  Schüler, H. & Ziegler, M., 2013 aug., I: The FEBS Journal. 280, 15, s. 3542

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

  • Adenosine Diphosphate 100%
  • Drug Development 66%
  • Malignant Neoplasm 33%
  • Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor 33%
  • Ischemia 33%

• Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains

  Forst, A. H., Karlberg, T., Herzog, N., Thorsell, A.-G., Gross, A., Feijs, K. L. H., Verheugd, P., Kursula, P., Nijmeijer, B., Kremmer, E., Kleine, H., Ladurner, A. G., Schüler, H. & Lüscher, B., 2013 mars 5, I: Structure. 21, 3, s. 462-75 14 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Macrodomain 100%
  • Adenosine Diphosphate 100%
  • Adenosine Diphosphate Ribose 33%
  • Isothermal Titration Calorimetry 11%
  • Mono Adenosine Diphosphate Ribosylation 11%
• 2012

  Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening

  Andersson, C. D., Karlberg, T., Ekblad, T., Lindgren, A. E. G., Thorsell, A.-G., Spjut, S., Uciechowska, U., Niemiec, M. S., Wittung-Stafshede, P., Weigelt, J., Elofsson, M., Schüler, H. & Linusson, A., 2012 sep. 13, I: Journal of Medicinal Chemistry. 55, 17, s. 7706-18 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Adenosine Diphosphate 100%
  • Virtual Screening 100%
  • Enzyme 50%
  • Clinical Trial 50%
  • Isothermal Titration Calorimetry 50%

• The corky root rot pathogen Pyrenochaeta lycopersici secretes a proteinaceous inducer of cell death affecting host plants differentially

  Clergeot, P.-H., Schuler, H., Mørtz, E., Brus, M., Vintila, S. & Ekengren, S., 2012 sep., I: Phytopathology. 102, 9, s. 878-91 14 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Cell Death 100%
  • Pyrenochaeta lycopersici 100%
  • Currants 25%
  • Root Cell 25%
  • Fast Protein Liquid Chromatography 12%

• Crystal structure of human ADP-ribose transferase ARTD15/PARP16 reveals a novel putative regulatory domain

  Karlberg, T., Thorsell, A.-G., Kallas, Å. & Schüler, H., 2012 juli 13, I: The Journal of biological chemistry. 287, 29, s. 24077-81 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Poly ADP Ribose Polymerase 100%
  • Crystal Structure 100%
  • Enzyme 66%
  • Transcription 33%
  • DNA Repair 33%

• Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

  Thangavelu, K., Pan, C. Q., Karlberg, T., Balaji, G., Uttamchandani, M., Suresh, V., Schüler, H., Low, B. C. & Sivaraman, J., 2012 maj 15, I: Proceedings of the National Academy of Sciences of the United States of America. 109, 20, s. 7705-10 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Glutaminase 100%
  • Sulfide 45%
  • Thioether 45%
  • Glutaminolysis 18%
  • Phosphoprotein Phosphatase 9%

• Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

  Wahlberg, E., Karlberg, T., Kouznetsova, E., Markova, N., Macchiarulo, A., Thorsell, A.-G., Pol, E., Frostell, Å., Ekblad, T., Öncü, D., Kull, B., Robertson, G. M., Pellicciari, R., Schüler, H. & Weigelt, J., 2012 feb. 19, I: Nature Biotechnology. 30, 3, s. 283-8 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor 100%
  • Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 100%
  • Tankyrase Inhibitor 100%
  • Poly ADP Ribose Polymerase 100%
  • Malignant Neoplasm 33%

• Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase

  Collins, R., Johansson, A.-L., Karlberg, T., Markova, N., van den Berg, S., Olesen, K., Hammarström, M., Flores, A., Schüler, H., Schiavone, L. H., Brzezinski, P., Arnér, E. S. J. & Högbom, M., 2012, I: PLoS ONE. 7, 1, e30581.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Selenocysteine 100%
  • Lyase 100%
  • Selenoprotein 22%
  • Selenide 22%
• 2011

  Critical role for a stage-specific actin in male exflagellation of the malaria parasite

  Deligianni, E., Morgan, R. N., Bertuccini, L., Kooij, T. W. A., Laforge, A., Nahar, C., Poulakakis, N., Schüler, H., Louis, C., Matuschewski, K. & Siden-Kiamos, I., 2011 nov., I: Cellular Microbiology. 13, 11, s. 1714-30 17 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Plasmodium 100%
  • Actin 100%
  • Gametogenesis 33%
  • Axoneme 22%
  • Host Cell 11%

• Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)₈ barrel enzymes

  Patton, G. C., Stenmark, P., Gollapalli, D. R., Sevastik, R., Kursula, P., Flodin, S., Schuler, H., Swales, C. T., Eklund, H., Himo, F., Nordlund, P. & Hedstrom, L., 2011 okt. 30, I: Nature Chemical Biology. 7, 12, s. 950-8 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Enzyme 100%
  • Reductase 100%
  • Dehydrogenase 100%
  • Guanosine Monophosphate 100%
  • Oxidoreductase 100%

• Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite

  Singh, B. K., Sattler, J. M., Chatterjee, M., Huttu, J., Schüler, H. & Kursula, I., 2011 aug. 12, I: The Journal of biological chemistry. 286, 32, s. 28256-64 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Plasmodium 100%
  • Depolymerization 100%
  • Globular Actin 9%
  • Apicomplexa 9%
  • Filamentous Actin 9%

• Comparative structural analysis of lipid binding START domains

  Thorsell, A.-G., Lee, W. H., Persson, C., Siponen, M. I., Nilsson, M., Busam, R. D., Kotenyova, T., Schüler, H. & Lehtiö, L., 2011, I: PLoS ONE. 6, 6, e19521.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Lipid 100%
  • Crystal Structure 20%
  • Ligand Binding 10%
  • Biomembrane 10%
  • Sequence Alignment 10%
• 2010

  Arp1, an actin-related protein, in Plasmodium berghei

  Siden-Kiamos, I., Schüler, H., Liakopoulos, D. & Louis, C., 2010 okt., I: Molecular and Biochemical Parasitology. 173, 2, s. 88-96 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Synapsin I 100%
  • Actin Related Protein 100%
  • Ookinete 40%
  • Chromatin Assembly and Disassembly 20%
  • baker's yeast 20%

• Comparative structural analysis of human DEAD-box RNA helicases

  Schütz, P., Karlberg, T., van den Berg, S., Collins, R., Lehtiö, L., Högbom, M., Holmberg-Schiavone, L., Tempel, W., Park, H.-W., Hammarström, M., Moche, M., Thorsell, A.-G. & Schüler, H., 2010 sep. 30, I: PLoS ONE. 5, 9, 11 s., e12791.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • RNA Helicase 100%
  • DEAD Box 100%
  • RNA 75%
  • Enzyme 25%
  • Binding Site 25%

• Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein

  Schütz, P., Wahlberg, E., Karlberg, T., Hammarström, M., Collins, R., Flores, A. & Schüler, H., 2010 juli 23, I: Journal of Molecular Biology. 400, 4, s. 768-82 15 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • RNA Helicase A 100%
  • Guanosine Triphosphate 25%
  • Cytidine Triphosphate 25%

• Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor

  Karlberg, T., Markova, N., Johansson, I., Hammarström, M., Schütz, P., Weigelt, J. & Schüler, H., 2010 juli 22, I: Journal of Medicinal Chemistry. 53, 14, s. 5352-5 4 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Wnt Signaling Pathway 100%
  • Telomere Homeostasis 50%
  • Poly ADP Ribose Polymerase 50%
  • Crystal Structure 50%

• Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite

  Huttu, J., Singh, B. K., Bhargav, S. P., Sattler, J. M., Schüler, H. & Kursula, I., 2010 maj 1, I: Acta crystallographica. Section F, Structural biology communications. 66, Pt 5, s. 583-7 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Actin 100%
  • Plasmodium 100%
  • Depolymerization 100%
  • X Ray 16%
  • Cell Invasion 16%

• Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector

  Hliscs, M., Sattler, J. M., Tempel, W., Artz, J. D., Dong, A., Hui, R., Matuschewski, K. & Schüler, H., 2010 apr. 9, I: The Journal of biological chemistry. 285, 15, s. 11572-83 12 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Cyclase 100%
  • Actin 100%
  • Oocyst 100%
  • Plasmodium 71%
  • C-Terminus 42%