Imen Chamkha

Sökresultat

• 2023

  A whole blood approach improves speed and accuracy when measuring mitochondrial respiration in intact avian blood cells

  Nord, A., Chamkha, I. & Elmer, E., 2023, I: FASEB Journal. 37, 12 s., e22766.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil

• Plasticity of mitochondrial function safeguards phosphorylating respiration during in vitro simulation of rest-phase hypothermia

  García-Díaz, C. C., Chamkha, I., Elmer, E. & Nord, A., 2023, I: FASEB Journal. 37, 4, e22854.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  Fil
• 2022

  Towards a treatment for mitochondrial disease: current compounds in clinical development

  Åsander Frostner, E., Simon Serrano, S., Chamkha, I., Elmer, E., Donnelly, E. & Hansson, M., 2022 juni 28, I: Bioenergetics Communications. 2022, 4, s. 1-10

  Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

  Öppen tillgång

  • Mitochondrial Diseases 100%
  • Drug Development 30%
  • Coenzymes 20%
  • Organelle Biogenesis 20%
  • Gene Expression Regulation 17%
• 2021

  Cell‐permeable succinate rescues mitochondrial respiration in cellular models of amiodarone toxicity

  Bețiu, A. M., Chamkha, I., Gustafsson, E., Meijer, E., Avram, V. F., Frostner, E. Å., Ehinger, J. K., Petrescu, L., Muntean, D. M. & Elmér, E., 2021 nov. 1, I: International Journal of Molecular Sciences. 22, 21, 11786.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Amiodarone 100%
  • Cell Respiration 89%
  • Prodrugs 82%
  • Platelets 81%
  • respiration 77%

• Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity

  Avram, V. F., Chamkha, I., Åsander-Frostner, E., Ehinger, J. K., Timar, R. Z., Hansson, M. J., Muntean, D. M. & Elmér, E., 2021, I: International Journal of Molecular Sciences. 22, 1, 15 s., 424.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 100%
  • Cell Respiration 97%
  • Platelets 88%
  • respiration 84%
  • toxicity 84%
• 2020

  Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose

  Piel, S., Chamkha, I., Kozak Dehlin, A., Ehinger, J. K., Sjövall, F., Elmér, E. & Hansson, M. J., 2020, I: PLoS ONE. 15, 4, e0231173.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Cell Respiration 100%
  • Succinic Acid 85%
  • Prodrugs 78%
  • Acetaminophen 74%
  • Liver 20%
• 2018

  Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production

  Piel, S., Ehinger, J. K., Chamkha, I., Frostner, E. Å., Sjövall, F., Elmér, E. & Hansson, M. J., 2018 aug. 1, I: Intensive Care Medicine Experimental. 6, 1, 22.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Succinic Acid 100%
  • Methylene Blue 97%
  • Metformin 88%
  • Energy Metabolism 74%
  • Lactic Acid 73%

• Do GSTM1 and GSTT1 polymorphisms influence the risk of developing mitochondrial diseases in a Tunisian population?

  Ghorbel, R., Ben Salah, G., Ghorbel, R., Ben Mahmoud, A., Chamkha, I., Mkaouar-Rebai, E., Ammar-Keskes, L. & Fakhfakh, F., 2018 feb., I: Environmental Science and Pollution Research. 25, 6, s. 5779-5787

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Mitochondrial Diseases 100%
  • Polymorphism 99%
  • polymorphism 84%
  • Reactive Oxygen Metabolite 75%
  • Oxidative Phosphorylation 66%
• 2017

  Co segregation of the m.1555A>G mutation in the MT-RNR1 gene and mutations in MT-ATP6 gene in a family with dilated mitochondrial cardiomyopathy and hearing loss: A whole mitochondrial genome screening

  Alila-Fersi, O., Chamkha, I., Majdoub, I., Gargouri, L., Mkaouar-Rebai, E., Tabebi, M., Tlili, A., Keskes, L., Mahfoudh, A. & Fakhfakh, F., 2017 feb. 26, I: Biochemical and Biophysical Research Communications. 484, 1, s. 71-78 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Mitochondrial Genome 100%
  • Dilated Cardiomyopathy 86%
  • Hearing Loss 75%
  • Mutation 67%
  • Cardiomyopathies 46%
• 2016

  Mitochondrial DNA triplication and punctual mutations in patients with mitochondrial neuromuscular disorders

  Mkaouar-Rebai, E., Felhi, R., Tabebi, M., Alila-Fersi, O., Chamkha, I., Maalej, M., Ammar, M., Kammoun, F., Keskes, L., Hachicha, M. & Fakhfakh, F., 2016 apr. 29, I: Biochemical and Biophysical Research Communications. 473, 2, s. 578-85 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Neuromuscular 100%
  • Mitochondrial Diseases 89%
  • Mitochondrial DNA 75%
  • Disorder 61%
  • Mutation 60%

• Whole mitochondrial genome analysis in two families with dilated mitochondrial cardiomyopathy: detection of mutations in MT-ND2 and MT-TL1 genes

  Alila, O. F., Rebai, E. M., Tabebi, M., Tej, A., Chamkha, I., Tlili, A., Bouguila, J., Tilouche, S., Soyah, N., Boughamoura, L. & Fakhfakh, F., 2016 juli, I: Mitochondrial DNA, Part A: DNA mapping, sequencing, and analysis. 27, 4, s. 2873-80 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Mitochondrial Genome 100%
  • Dilated Cardiomyopathy 86%
  • Mutation 44%
  • Genes 32%
  • Mitochondrial DNA 27%
• 2014

  A mitochondrial implication in a Tunisian patient with Friedreich's ataxia-like

  Maalej, M., Mkaouar-Rebai, E., Mnif, M., Mezghani, N., Ben Ayed, I., Chamkha, I., Abid, M. & Fakhfakh, F., 2014 feb., I: Pathologie Biologie. 62, 1, s. 41-8 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Ataxia with vitamin E deficiency 100%
  • frataxin 41%
  • Friedreich Ataxia 37%
  • Mitochondrial DNA 35%
  • Genes 21%

• A novel MT-CO2 m.8249G>A pathogenic variation and the MT-TW m.5521G>A mutation in patients with mitochondrial myopathy

  Mkaouar-Rebai, E., Ben Mahmoud, A., Chamkha, I., Chabchoub, I., Kammoun, T., Hachicha, M. & Fakhfakh, F., 2014 okt., I: Mitochondrial DNA. 25, 5, s. 394-9 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Mitochondrial Myopathies 100%
  • Transfer RNA 55%
  • Mutation 38%
  • Mitochondrial DNA 35%
  • RNA, Transfer, Trp 31%
• 2013

  A novel MT-CO1 m.6498C>A variation associated with the m.7444G>A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes in a patient with hearing impairment, diabetes and congenital visual loss

  Mkaouar-Rebai, E., Chamkha, I., Kammoun, T., Alila-Fersi, O., Aloulou, H., Hachicha, M. & Fakhfakh, F., 2013 jan. 11, I: Biochemical and Biophysical Research Communications. 430, 2, s. 585-91 7 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • tRNA(Ser) 100%
  • RNA, Transfer, Ser 89%
  • Hearing Loss 50%
  • Mutation 44%
  • tRNA(Leu) 24%

• Screening of mitochondrial mutations in Tunisian patients with mitochondrial disorders: an overview study

  Mkaouar-Rebai, E., Chamkha, I., Mezghani, N., Ben Ayed, I. & Fakhfakh, F., 2013 juni, I: Mitochondrial DNA. 24, 3, s. 163-78 16 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Mitochondrial Diseases 100%
  • Mutation 44%
  • MELAS Syndrome 40%
  • Wolfram Syndrome 29%
  • Kearns-Sayre Syndrome 28%
• 2012

  A novel m.12908T>a mutation in the mitochondrial ND5 gene in patient with infantile-onset Pompe disease

  Chamkha, I., Alila-Fersi, O., Mkaouar-Rebai, E., Aloulou, H., Kifagi, C., Hachicha, M. & Fakhfakh, F., 2012 dec. 7, I: Biochemical and Biophysical Research Communications. 429, 1-2, s. 31-8 8 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Glycogen Storage Disease Type II 100%
  • Mitochondrial Genes 88%
  • Mutation 58%
  • Muscle Hypotonia 55%
  • Glucosidases 34%

• Possible association of a novel missense mutation A6375G in the mitochondrial cytochrome C oxidase I gene with asthenospermia in the Tunisian population

  Baklouti-Gargouri, S., Ghorbel, M., Chamkha, I., Mkaouar-Rebai, E., Sellami, A., Chakroun, N., Fakhfakh, F. & Ammar-Keskes, L., 2012 nov., I: Genetic Testing and Molecular Biomarkers. 16, 11, s. 1298-302 5 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Electron Transport Complex IV 100%
  • Missense Mutation 88%
  • Genes 34%
  • Population 33%
  • Mitochondrial Genes 21%
• 2011

  A novel m.3395A>G missense mutation in the mitochondrial ND1 gene associated with the new tRNA(Ile) m.4316A>G mutation in a patient with hypertrophic cardiomyopathy and profound hearing loss

  Chamkha, I., Mkaouar-Rebai, E., Aloulou, H., Chabchoub, I., Kifagi, C., Fendri-Kriaa, N., Kammoun, T., Hachicha, M. & Fakhfakh, F., 2011 jan. 7, I: Biochemical and Biophysical Research Communications. 404, 1, s. 504-10 7 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • tRNA(Ile) 100%
  • RNA, Transfer, Ile 95%
  • Mitochondrial Genes 67%
  • Hypertrophic Cardiomyopathy 60%
  • Missense Mutation 55%

• A Tunisian patient with Pearson syndrome harboring the 4.977kb common deletion associated to two novel large-scale mitochondrial deletions

  Ayed, I. B., Chamkha, I., Mkaouar-Rebai, E., Kammoun, T., Mezghani, N., Chabchoub, I., Aloulou, H., Hachicha, M. & Fakhfakh, F., 2011 juli 29, I: Biochemical and Biophysical Research Communications. 411, 2, s. 381-6 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Protein Synthesis 100%
  • Refractory 99%
  • Pharmacological Metabolism 74%
  • Refractory Anemia 45%
  • Energy 45%

• Molecular-clinical correlation in a family with a novel heteroplasmic Leigh syndrome missense mutation in the mitochondrial cytochrome c oxidase III gene

  Mkaouar-Rebai, E., Ellouze, E., Chamkha, I., Kammoun, F., Triki, C. & Fakhfakh, F., 2011 jan., I: Journal of Child Neurology. 26, 1, s. 12-20 9 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Leigh Disease 100%
  • Electron Transport Complex IV 78%
  • Mouth Mucosa 72%
  • Missense Mutation 68%
  • Ectoderm 42%
• 2010

  A case of Kearns-Sayre syndrome with two novel deletions (9.768 and 7.253 kb) of the mtDNA associated with the common deletion in blood leukocytes, buccal mucosa and hair follicles

  Mkaouar-Rebai, E., Chamkha, I., Kammoun, T., Chabchoub, I., Aloulou, H., Fendri, N., Hachicha, M. & Fakhfakh, F., 2010 aug., I: Mitochondrion. 10, 5, s. 449-55 7 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Kearns-Sayre Syndrome 100%
  • Hair Follicle 72%
  • Mouth Mucosa 67%
  • Mitochondrial DNA 65%
  • Leukocytes 49%

• A de novo mutation in the adenosine triphosphatase (ATPase) 8 gene in a patient with mitochondrial disorder

  Mkaouar-Rebai, E., Kammoun, F., Chamkha, I., Kammoun, N., Hsairi, I., Triki, C. & Fakhfakh, F., 2010 juni, I: Journal of Child Neurology. 25, 6, s. 770-5 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Mitochondrial Diseases 100%
  • Adenosine Triphosphatases 80%
  • White Matter 48%
  • Mutation 44%
  • Interpeduncular Nucleus 41%
• 2009

  Two new mutations in the MT-TW gene leading to the disruption of the secondary structure of the tRNA(Trp) in patients with Leigh syndrome

  Mkaouar-Rebai, E., Chamkha, I., Kammoun, F., Kammoun, T., Aloulou, H., Hachicha, M., Triki, C. & Fakhfakh, F., 2009 juli, I: Molecular Genetics and Metabolism. 97, 3, s. 179-84 6 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • tRNA(Trp) 100%
  • RNA, Transfer, Trp 98%
  • Leigh Disease 78%
  • Secondary Structure 45%
  • Mutation 44%