Staffan Larsson

2022

Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS-5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip

van der Aar, E., Deckx, H., Dupont, S., Fieuw, A., Delage, S., Larsson, S., Struglics, A., Lohmander, L. S., Lalande, A., Leroux, E., Amantini, D. & Passier, P., 2022, I: Clinical Pharmacology in Drug Development. 11, 1, s. 112-122 11 s.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury

Aulin, C., Larsson, S., Vogl, T., Roth, J., Åkesson, A., Swärd, P., Heinbäck, R., Erlandsson Harris, H. & Struglics, A., 2022, I: Osteoarthritis and Cartilage. 30, 9, s. 1198-1209 12 s.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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2021

An Anterior Cruciate Ligament Rupture Increases Levels of Urine N-terminal Cross-linked Telopeptide of Type I Collagen, Urine C-terminal Cross-linked Telopeptide of Type II Collagen, Serum Aggrecan ARGS Neoepitope, and Serum Tumor Necrosis Factor–α

Hagemans, F. J. A., Larsson, S., Reijman, M., Frobell, R. B., Struglics, A. & Meuffels, D. E., 2021, I: American Journal of Sports Medicine. 49, 13, s. 3534-3543

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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2020

Higher aggrecan 1-F21 epitope concentration in synovial fluid early after anterior cruciate ligament injury is associated with worse knee cartilage quality assessed by gadolinium enhanced magnetic resonance imaging 20 years later

Neuman, P., Larsson, S., Lohmander, L. S. & Struglics, A., 2020, I: BMC Musculoskeletal Disorders. 21, 1, 798.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Molecular and imaging biomarkers of local inflammation at 2 years after anterior cruciate ligament injury do not associate with patient reported outcomes at 5 years

Struglics, A., Turkiewicz, A., Larsson, S., Lohmander, L. S., Roemer, F. W., Frobell, R. & Englund, M., 2020 mars 1, I: Osteoarthritis and Cartilage. 28, 3, s. 356-362 7 s.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

2019

Impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Bricca, A., Struglics, A., Larsson, S., Steultjens, M., Juhl, C. B. & Roos, E. M., 2019 nov., I: Arthritis care and research : the official journal of the Arthritis Health Professions Association. 71, 11, s. 1504-1515 12 s.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Molecular and Structural Biomarkers of Inflammation at Two Years After Acute Anterior Cruciate Ligament Injury Do Not Predict Structural Knee Osteoarthritis at Five Years

Roemer, F. W., Englund, M., Turkiewicz, A., Struglics, A., Guermazi, A., Lohmander, L. S., Larsson, S. & Frobell, R., 2019, I: Arthritis and Rheumatology. 71, 2, s. 238-243

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Reply to letter by Deng et al. "Could the levels of inflammation biomarkers predict OA? Comment on the article by Roemer FW et al."

Roemer, F. W., Englund, M., Turkiewicz, A., Struglics, A., Guermazi, A., Lohmander, L. S., Larsson, S. & Frobell, R., 2019, I: Arthritis & Rheumatology. 71, 9, s. 1588-1588

Forskningsoutput: Tidskriftsbidrag › Letter

2018

Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5 years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial

Struglics, A., Larsson, S., Pramhed, A., Frobell, R. & Swärd, P., 2018 jan., I: Osteoarthritis and Cartilage. 26, 10, s. 1351-1358

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., 2018 juni, I: Osteoarthritis and Cartilage. 26, 6, s. 834-843

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Time between anterior cruciate ligament injury and reconstruction and cartilage metabolism six-months following reconstruction

Davis, H. C., Spang, J. T., Loeser, R. F., Larsson, S., Ulici, V., Troy Blackburn, J., Creighton, R. A., Kamath, G. M., Jordan, J. M., Marshall, S. W. & Pietrosimone, B., 2018 mars, I: Knee. 25, 2, s. 296-305

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

α₁-microglobulin protects against bleeding-induced oxidative damage in knee arthropathies

Larsson, S., Åkerström, B., Gram, M., Stefan Lohmander, L. & Struglics, A., 2018 nov. 16, I: Frontiers in Physiology. 9, NOV, 1596.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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2017

Surgical reconstruction of ruptured anterior cruciate ligament prolongs trauma-induced increase of inflammatory cytokines in synovial fluid: An exploratory analysis in the KANON trial

Larsson, S., Struglics, A., Lohmander, L. S. & Frobell, R., 2017 sep., I: Osteoarthritis and Cartilage. 25, 9, s. 1443-1451

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

2015

Changes in synovial fluid and serum cytokines and ARGS-aggrecan, and urine CTX-II and NTX-I over five years after anterior cruciate ligament rupture: An exploratory analysis in the KANON trial.

Struglics, A., Larsson, S., Kumahashi, N., Frobell, R. & Lohmander, S., 2015, I: Arthritis & Rheumatology. 67, 7, s. 1816-1825

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy.

Larsson, S., Englund, M., Struglics, A. & Lohmander, S., 2015, I: Osteoarthritis and Cartilage. 23, 11, s. 1906-1914

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Type II collagen C2C epitope in human synovial fluid and serum after knee injury - associations with molecular and structural markers of injury.

Kumahashi, N., Swärd, P., Larsson, S., Lohmander, S., Frobell, R. & Struglics, A., 2015, I: Osteoarthritis and Cartilage. 23, 9, s. 1506-1512

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

2014

An ARGS-aggrecan assay for analysis in blood and synovial fluid.

Larsson, S., Lohmander, S. & Struglics, A., 2014, I: Osteoarthritis and Cartilage. 22, 2, s. 242-249

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

2012

The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study.

Larsson, S., Englund, M., Struglics, A. & Lohmander, S., 2012, I: Osteoarthritis and Cartilage. 20, 5, s. 388-395

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

2011

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

Chockalingam, P. S., Sun, W., Rivera-Bermudez, M. A., Zeng, W., Dufield, D. R., Larsson, S., Lohmander, S., Flannery, C. R., Glasson, S. S., Georgiadis, K. E. & Morris, E. A., 2011, I: Osteoarthritis and Cartilage. 19, 3, s. 315-323

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

2010

A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid.

Struglics, A. & Larsson, S., 2010, I: Matrix Biology. 29, s. 74-83

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Aggrecan fragments as biomarkers in osteoarthritis

Larsson, S., 2010, Lund Univerity, Faculty of Medicine, Clinical Sciences Lund, Department of Orthopaedics, SE-221 84 Lund, Sweden. 130 s.

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Fil

869 Nedladdningar (Pure)

Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.

Larsson, S., Englund, M., Struglics, A. & Lohmander, S., 2010, I: Arthritis Research and Therapy. 12, 6, R230.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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158 Nedladdningar (Pure)

The association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression of knee osteoarthritis

Larsson, S., Englund, M., Struglics, A. & Lohmander, S., 2010, I: Osteoarthritis and Cartilage. 18, Supplement 2, s. S59-S60

Forskningsoutput: Tidskriftsbidrag › Publicerat konferensabstract

2009

Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study

Larsson, S., Lohmander, S. & Struglics, A., 2009, I: Arthritis Research and Therapy. 11, 3

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases.

Struglics, A., Larsson, S., Björklund, M. & Lohmander, S., 2009, I: Osteoarthritis and Cartilage. 17, s. 497-506

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

2006

Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments

Pratta, M. A., Su, J. L., Leesnitzer, M. A., Struglics, A., Larsson, S., Lohmander, S. & Kumar, S., 2006, I: Osteoarthritis and Cartilage. 14, 7, s. 702-713

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Estimation of the identity of proteolytic aggrecan fragments using PAGE migration and Western immunoblot.

Struglics, A., Larsson, S. & Lohmander, S., 2006, I: Osteoarthritis and Cartilage. 14, 9, s. 898-905

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.

Struglics, A., Larsson, S., Pratta, M. A., Kumar, S., Lark, M. W. & Lohmander, S., 2006, I: Osteoarthritis and Cartilage. 14, 2, s. 101-113

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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164 Nedladdningar (Pure)

2005

Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis.

Lohmander, S., Brandt, K. D., Mazzuca, S. A., Katz, B. P., Larsson, S., Struglics, A. & Lane, K. A., 2005, I: Arthritis and Rheumatism. 52, 10, s. 3160-3167

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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2003

Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells.

Sitnicka Quinn, E., Buza-Vidas, N., Larsson, S., Nygren, J., Liuba, K. & Jacobsen, S. E. W., 2003, I: Blood. 102, 3, s. 881-886

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Staffan Larsson

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