Tommaso de Marchi

Sökresultat

• 2025

  Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division

  Bui, H., Andersson, S., Sola-Carvajal, A., De Marchi, T., Vähäkangas, E., Holopainen, M., House, A. H., Rovenko, B. M., Englund, J. I., Kasper, M., Kuuluvainen, E., Käkelä, R., Hietakangas, V., Niméus, E. & Katajisto, P., 2025 dec., I: Nature Communications. 16, 1, 3932.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Glucose-6-Phosphate Dehydrogenase 100%
  • Peroxisome 100%
  • Asymmetric Cell Division 100%
  • Daughter Cell 25%
  • Ether Lipid 12%

• The potential radiosensitization target PFKFB3 is related to response to radiotherapy in SweBCG91RT: a randomized clinical trial with long-term follow-up

  Egelberg, M., De Marchi, T., Schultz, N., Tran, L., Karlsson, P., Holmberg, E., Pekar, G., Killander, F. & Niméus, E., 2025, I: BMC Cancer. 25, 1, 374.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Gamma Urogastrone 100%
  • Radiosensitization 100%
  • Cancer Cell 50%
  • DNA Microarray 50%
  • Whole Cell 50%
• 2024

  Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

  De Marchi, T., Lai, C.-F., Simmons, G. M., Goldsbrough, I., Harrod, A., Lam, T., Buluwela, L., Kjellström, S., Brueffer, C., Saal, L. H., Malmström, J., Ali, S. & Niméus, E., 2024 mars 22, I: Scientific Reports. 14, s. 1-16 6873.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Proteomics 100%
  • Protein 25%
  • Regulatory Mechanism 25%
  • Protein Expression 25%
  • Gene 12%

• Evaluation of alternative prognostic thresholds for SP142 and 22C3 immunohistochemical PD-L1 expression in triple-negative breast cancer: results from a population-based cohort

  Sigurjonsdottir, G., De Marchi, T., Ehinger, A., Hartman, J., Ullén, S., Leandersson, K., Bosch, A., Staaf, J., Killander, F. & Niméus, E., 2024, (E-pub ahead of print) I: Breast Cancer Research and Treatment.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Programmed Death-Ligand 1 100%
  • Triple Negative Breast Cancer 100%
  • PD-L1 100%
  • Androgen Receptor 33%
  • Neoplasm 27%
• 2023

  Comparison of SP142 and 22C3 PD-L1 assays in a population-based cohort of triple-negative breast cancer patients in the context of their clinically established scoring algorithms

  Sigurjonsdottir, G., De Marchi, T., Ehinger, A., Hartman, J., Bosch, A., Staaf, J., Killander, F. & Niméus, E., 2023 dec., I: Breast Cancer Research. 25, 1, 123.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Neoplasm 100%
  • Triple Negative Breast Cancer 100%
  • PD-L1 100%
  • Programmed Death-Ligand 1 100%
  • Antibodies 25%

• Proteogenomics decodes the evolution of human ipsilateral breast cancer

  De Marchi, T., Pyl, P. T., Sjöström, M., Reinsbach, S. E., DiLorenzo, S., Nystedt, B., Tran, L., Pekar, G., Wärnberg, F., Fredriksson, I., Malmström, P., Fernö, M., Malmström, L., Malmstöm, J. & Niméus, E., 2023 dec., I: Communications Biology. 6, 1, 139.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Evolution 100%
  • Proteogenomics 100%
  • Recurrent Disease 40%
  • Proteome 33%
  • Somatic Mutation 33%

• Low levels of WRAP53 predict decreased efficacy of radiotherapy and are prognostic for local recurrence and death from breast cancer: a long-term follow-up of the SweBCG91RT randomized trial

  Egelberg, M., De Marchi, T., Pekar, G., Tran, L., Bendahl, P. O., Tullberg, A. S., Holmberg, E., Karlsson, P., Farnebo, M., Killander, F. & Nimeús, E., 2023, I: Molecular Oncology. 17, 10, s. 2029-2040

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Follow up 100%
  • Death 100%
  • Breast Cancer 100%
  • Protein P53 100%
  • P53 100%
• 2022

  Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics

  Chianese, U., Papulino, C., Passaro, E., Evers, T. M., Babaei, M., Toraldo, A., De Marchi, T., Niméus, E., Carafa, V., Nicoletti, M. M., Del Gaudio, N., Iaccarino, N., Randazzo, A., Rotili, D., Mai, A., Cappabianca, S., Mashaghi, A., Ciardiello, F., Altucci, L. & Benedetti, R., 2022 okt., I: Molecular Metabolism. 64, 101561.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Metabolic Pathway 100%
  • Histone 100%
  • Mechanics 100%
  • Demethylase 100%
  • Metabolism 100%

• A somatic mutation in moesin drives progression into acute myeloid leukemia

  Yuan, O., Ugale, A., de Marchi, T., Anthonydhason, V., Konturek-Ciesla, A., Wan, H., Eldeeb, M., Drabe, C., Jassinskaja, M., Hansson, J., Hidalgo, I., Velasco-Hernandez, T., Cammenga, J., Magee, J. A., Niméus, E. & Bryder, D., 2022, I: Science Advances. 8, 16, eabm9987.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Drive 100%
  • Myeloid 100%
  • Somatic Mutation 100%
  • Protein 60%
  • Leukemogenesis 40%
• 2021

  Proteogenomic Workflow Reveals Molecular Phenotypes Related to Breast Cancer Mammographic Appearance

  De Marchi, T., Pyl, P. T., Sjöström, M., Klasson, S., Sartor, H., Tran, L., Pekar, G., Malmström, J., Malmström, L. & Niméus, E., 2021, I: Journal of Proteome Research. 20, 5, s. 2983-3001 19 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Phenotype 100%
  • Protein 100%
  • Proteogenomics 100%
  • RNA 25%

• Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer

  Benedetti, R., Papulino, C., Sgueglia, G., Chianese, U., De Marchi, T., Iovino, F., Rotili, D., Mai, A., Niméus, E., Aversana, C. D. & Altucci, L., 2021, I: Cancers. 13, 3, 19 s., 543.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Regulatory Mechanism 100%
  • MicroRNA 66%
  • Epigenetics 66%
  • Endocrine Therapy 57%
  • Hybrid 33%
• 2019

  Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer

  Benedetti, R., Dell’aversana, C., De Marchi, T., Rotili, D., Liu, N. Q., Novakovic, B., Boccella, S., Di Maro, S., Cosconati, S., Baldi, A., Niméus, E., Schultz, J., Höglund, U., Maione, S., Papulino, C., Chianese, U., Iovino, F., Federico, A., Mai, A. & Stunnenberg, H. G. & 2 andra, Nebbioso, A. & Altucci, L., 2019, I: Cancers. 11, 12, 2027.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Histone 100%
  • Demethylase 100%
  • Lysine 100%
  • Histone Methylation 28%
  • Neoplasm 16%
• 2017

  Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

  De Marchi, T., Timmermans, M. A., Sieuwerts, A. M., Smid, M., Look, M. P., Grebenchtchikov, N., Sweep, F. C. G. J., Smits, J. G., Magdolen, V., van Deurzen, C. H. M., Foekens, J. A., Umar, A. & Martens, J. W. M., 2017 maj 18, I: Scientific Reports. 7, 1, 2099.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Aminotransferase 100%
  • Phosphoserine 100%
  • Recurrent Disease 20%
  • RNA Directed DNA Polymerase 20%
  • Hormone Cancer Therapy 10%
• 2016

  Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients

  Liu, N. Q., De Marchi, T., Timmermans, A. M., Trapman-Jansen, A. M. A. C., Foekens, R., Look, M. P., Smid, M., van Deurzen, C. H. M., Span, P. N., Sweep, F. C. G. J., Brask, J. B., Timmermans-Wielenga, V., Foekens, J. A., Martens, J. W. M. & Umar, A., 2016 aug. 25, I: Scientific Reports. 6, s. 32027

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Kinase 100%
  • Gene Set Enrichment Analysis 100%
  • Uridine Monophosphate 100%
  • Cytidine Monophosphate 100%
  • Patient 100%

• Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer

  De Marchi, T., Foekens, J. A., Umar, A. & Martens, J. W. M., 2016 juli, I: Drug Discovery Today. 21, 7, s. 1181-8 8 s.

  Forskningsoutput: Tidskriftsbidrag › Översiktsartikel › Peer review

  • Hormone Therapy 100%
  • Estrogen Receptor Positive Breast Cancer 100%
  • Therapy Resistance 100%
  • Endocrine Therapy 100%
  • Therapeutic Procedure 50%

• The advantage of laser-capture microdissection over whole tissue analysis in proteomic profiling studies

  De Marchi, T., Braakman, R. B. H., Stingl, C., van Duijn, M. M., Smid, M., Foekens, J. A., Luider, T. M., Martens, J. W. M. & Umar, A., 2016 maj, I: Proteomics. 16, 10, s. 1474-85

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Proteomics 100%
  • Laser Capture Microdissection 100%
  • Protein 71%
  • Biomarker Discovery 14%
  • Peptide 14%

• Targeted MS Assay Predicting Tamoxifen Resistance in Estrogen-Receptor-Positive Breast Cancer Tissues and Sera

  De Marchi, T., Kuhn, E., Dekker, L. J. M., Stingl, C., Braakman, R. B. H., Opdam, M., Linn, S. C., Sweep, F. C. G. J., Span, P. N., Luider, T. M., Foekens, J. A., Martens, J. W. M., Carr, S. A. & Umar, A., 2016 apr. 1, I: Journal of Proteome Research. 15, 4, s. 1230-42 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Protein 100%
  • Tamoxifen 100%
  • Serum 100%
  • Cancer Tissue 100%
  • Estrogen Receptor Positive Breast Cancer 100%

• Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer

  De Marchi, T., Timmermans, A. M., Smid, M., Look, M. P., Stingl, C., Opdam, M., Linn, S. C., Sweep, F. C. G. J., Span, P. N., Kliffen, M., van Deurzen, C. H. M., Luider, T. M., Foekens, J. A., Martens, J. W. M. & Umar, A., 2016 jan. 19, I: Oncotarget. 7, 3, s. 3098-3110 13 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Protein 100%
  • Mass Spectrometry 60%
  • Staining 40%
  • Staining Technique 40%
  • Resolution (Mass Spectrometry) 20%

• 4-protein signature predicting tamoxifen treatment outcome in recurrent breast cancer

  De Marchi, T., Liu, N. Q., Stingl, C., Timmermans, M. A., Smid, M., Look, M. P., Tjoa, M., Braakman, R. B. H., Opdam, M., Linn, S. C., Sweep, F. C. G. J., Span, P. N., Kliffen, M., Luider, T. M., Foekens, J. A., Martens, J. W. M. & Umar, A., 2016 jan., I: Molecular Oncology. 10, 1, s. 24-39 16 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Therapeutic Procedure 100%
  • Protein 100%
  • Breast Cancer 100%
  • Tamoxifen 100%
  • Patient 28%
• 2015

  Global proteomic characterization of microdissected estrogen receptor positive breast tumors

  De Marchi, T., Liu, N. Q., Sting, C., Smid, M., Tjoa, M., Braakman, R. B. H., Luider, T. M., Foekens, J. A., Martens, J. W. M. & Umar, A., 2015 dec., I: Data in Brief. 5, s. 399-402 4 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Patient 100%
  • Therapeutic Procedure 100%
  • Breast Tumor 100%
  • Estrogen Receptor 100%
  • Training 100%

• Antibody-based capture of target peptides in multiple reaction monitoring experiments

  De Marchi, T., Kuhn, E., Carr, S. A. & Umar, A., 2015, Mammary Stem Cells: Methods and Protocols. Humana Press, s. 123-35 (Methods in Molecular Biology; vol. 1293).

  Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Kapitel samlingsverk › Forskning › Peer review

  • Experiment 100%
  • Antibody 100%
  • Peptide 100%
  • Chemical Reaction 100%
  • Mass Spectrometry 100%
• 2014

  Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response

  Liu, N. Q., De Marchi, T., Timmermans, A. M., Beekhof, R., Trapman-Jansen, A. M. A. C., Foekens, R., Look, M. P., van Deurzen, C. H. M., Span, P. N., Sweep, F. C. G. J., Brask, J. B., Timmermans-Wielenga, V., Debets, R., Martens, J. W. M., Foekens, J. A. & Umar, A., 2014 juli, I: Molecular and Cellular Proteomics. 13, 7, s. 1814-27 14 s.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • T-Cell Response 100%
  • T Cell 100%
  • Patient 40%
  • Mass Spectrum 40%
  • Prognosis 40%

• Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer

  Liu, N. Q., Stingl, C., Look, M. P., Smid, M., Braakman, R. B. H., De Marchi, T., Sieuwerts, A. M., Span, P. N., Sweep, F. C. G. J., Linderholm, B. K., Mangia, A., Paradiso, A., Dirix, L. Y., Van Laere, S. J., Luider, T. M., Martens, J. W. M., Foekens, J. A. & Umar, A., 2014 feb., I: Journal of the National Cancer Institute. 106, 2, djt376.

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  Öppen tillgång

  • Patient 100%
  • Protein 100%
  • Proteome Analysis 100%
  • Prognosis 70%
  • Training 66%
• 2013

  Quantitative proteomic analysis of microdissected breast cancer tissues: comparison of label-free and SILAC-based quantification with shotgun, directed, and targeted MS approaches

  Liu, N. Q., Dekker, L. J. M., Stingl, C., Güzel, C., De Marchi, T., Martens, J. W. M., Foekens, J. A., Luider, T. M. & Umar, A., 2013 okt. 4, I: Journal of Proteome Research. 12, 10, s. 4627-41

  Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

  • Protein 100%
  • Label-Free Quantification 100%
  • Quantitative Proteomics 100%
  • Biomarker Discovery 25%
  • Biomarker Validation 25%