Dietary plasma biomarkers as a complement to self-reported diet when linking food patterns to gut microbiota and cardiometabolic health

Projekt: Forskning

Projektinformation

Beskrivning

Background:
According to the Global Burden of Disease, unhealthy diet contributes to a third of all cardiovascular disease (CVD) deaths globally. Diet is also an important factor shaping our gut microbiota, which is modified in individuals with cardiometabolic disease. Some gut microbiota species use food components to produce metabolites, such as short-chain fatty acids, that can affect glucose and lipid metabolism. Objective dietary plasma biomarker data can improve dietary data and facilitate detection of associations between food patterns and cardiometabolic health.

Objectives:
The aim of this project is to examine dietary patterns, based on dietary biomarkers in plasma and self-reports, and gut microbiota in relation to cardiometabolic disease. We will examine dietary patterns and adherence to the Swedish dietary guidelines in relation to gut microbial species abundance and diversity, SCFA in plasma, risk markers of cardio metabolic disease, and incidence of CVD and type 2 diabetes (T2D).

Study population and data:

We will use data from two large well-characterized cohorts with dietary data; the Swedish CArdioPulmonary bioImage Study (SCAPIS) (n=29,200) and the Malmö offspring study (MOS)(n=3800). Faeces samples were collected in 10,000 of the participants for deep shotgun metagenomics sequencing to evaluate composition and diversity of the gut microbiota.

Significance:
Dietary guidelines have a crucial role in national health efforts as poor diet contributes to a large part of the enormous burden of cardiometabolic disease. Insight about how diet relates to our gut microbiota needs to be addressed as such connection may be an underlying mechanism linking diet to cardiometabolic disease. By adding dietary biomarker data to self-reported dietary data, this project will contribute understanding of interplay between diet, gut microbiota and cardiometabolic health to consider when designing evidence-based dietary guidelines.
StatusPågående
Gällande start-/slutdatum2025/01/012026/12/31

Finansiering

  • Dir Albert Påhlssons stiftelse för forskning och välgörenhet