Epidemiology, diagnosis and outcome of aortic graft and endograft infections

Epidemiology of AGEIs: In patients with aortic grafts or endografts suffering from a bloodstream infection, the risk of AGEI is currently unknown. This theses will investigate the incidence and trends of AGEIs in Skåne Sweden and analyze demographic and clinical factors associated with risk of infection. This involves the studying if specific patient-related risk factors contribute to aortic graft and endograft infections. This could involve analyzing factors such as age, comorbidities (diabetes, immunosuppression), pre- existing infections, and lifestyle factors to determine which patients are most vulnerable.

Diagnostic techniques: Improving diagnostic techniques for early detection of aortic graft and endograft infections. Investigating the accuracy of PET-CT scans to diagnose infections more accurately and quickly.

Microbial profiling: Investigating the microbial composition of infections associated with aortic grafts and endografts. This will be done ny studying the types of bacteria commonly responsible for these infections, as well as their antibiotic resistance patterns. Understanding the microbiology can inform targeted antibiotic strategies.
Biofilm formation: Research of the formation of biofilms on aortic grafts and endografts, as these biofilms are often associated with persistent infections. Explore strategies to prevent or disrupt biofilm formation, potentially through the use of antibiofilm agents or coatings.

Long-term outcomes: register-bassed, long-term follow-up studies to assess the outcomes of patients who have undergone treatment for aortic graft and endograft infections. Evaluate factors such as graft durability, quality of life, and incidence of re-infection to guide clinical decision- making.