Is good muscle function a protective factor for early features of knee osteoarthritis (SHIELD)? A prospective cohort study

In this longitudinal prospective cohort study including young people with anterior cruciate ligament reconstruction, we will 1) study the association between different measures of muscle function and early future knee OA assessed as patient-reported pain, 2) monitor the patients’ functional status, and early OA development over time, 3) explore potential associations between muscle function and features indicative of early radiographic OA measured with MRI (MRI-OA), and early detection of OA in biomarker profiles, respectively. The main hypothesis is that knee extensor weakness predicts future symptomatic OA of the knee (KOOS pain).

Study whether muscle function is a protective factor for future joint problems after knee injury