Projektinformation

Beskrivning

The dissertation deals with identifying the mechanisms of dexamethasone resistance in B-ALL, and mechanisms of venetoclax resistance in T-ALL. We have also identified mono or combination therapies to overcome this resistance.

Populärvetenskaplig beskrivning

Acute lymphoblastic leukemia comprises both B-ALL and T-ALL. The dissertation deals with identifying the mechanisms of resistance to a glucocorticoid, dexamethasone in B-ALL and a BCL2 inhibitor, venetoclax in T-ALL. We have also identified mono or combination therapies to overcome this resistance.
StatusSlutfört
Gällande start-/slutdatum2017/08/012021/10/31

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi
  • Annan medicinsk grundvetenskap