Paving the way for anti-inflammatory treatments in Moyamoya disease

1. To test if MRTFs act in synergy with NOTCH to promote NO-signaling.
2. To examine if the MRTF-SRF target gene NEXN counteracts aneurysm-formation.
3. To address if MRTF-SRF signaling regulates focal adhesions and vascular disease in vivo.
4. To examine whether MRTFs regulate plaque stability via MBNL1-AS1.