Projektinformation
Beskrivning
Background
Pulmonary hypertension (PH) is associated with significant morbidity and mortality. Pulmonary vasodilator therapy has been shown to reduce pulmonary vascular resistance and alleviate symptoms. Strategies for therapy in children have so far mainly been off-label and based on adult trials and experience. Additional data on safety and efficacy of pulmonary vasodilators in children is needed, as well as data on the mechanisms behind vascular remodeling in different groups of PH and group specific treatment effects.
Aims
-to assess effects of pulmonary vasodilator therapy in children with PH associated with complex congenital heart defects
-to evaluate the national and regional use of pulmonary vasodilator therapy in the Swedish paediatric population and
-to analyse the vascular changes in PH using synchrotron-based phase contrast micro-CT.
Pulmonary hypertension (PH) is associated with significant morbidity and mortality. Pulmonary vasodilator therapy has been shown to reduce pulmonary vascular resistance and alleviate symptoms. Strategies for therapy in children have so far mainly been off-label and based on adult trials and experience. Additional data on safety and efficacy of pulmonary vasodilators in children is needed, as well as data on the mechanisms behind vascular remodeling in different groups of PH and group specific treatment effects.
Aims
-to assess effects of pulmonary vasodilator therapy in children with PH associated with complex congenital heart defects
-to evaluate the national and regional use of pulmonary vasodilator therapy in the Swedish paediatric population and
-to analyse the vascular changes in PH using synchrotron-based phase contrast micro-CT.
| Status | Pågående |
|---|---|
| Gällande start-/slutdatum | 2018/02/01 → … |