Targeting metabolic re-programming in the bronchial epithelium for new treatment options of viral-induced asthma exacerbations

Projekt: Forskning

Projektinformation

Beskrivning

Asthma is a chronic inflammatory respiratory disorder that affects many million people around the world. The airway epithelium forms an immunological barrier between innate and adaptive immunity and is the first line of defense against invading pathogens. Infections with respiratory viruses, in particular rhinovirus, are a frequent cause of exacerbations, contributing to disease pathogenesis. Immune tolerance and resistance towards respiratory infections are aberrant in the bronchial epithelium in asthma. Immune activation and differentiation are accompanied by comprehensive changes in cellular metabolism. Metabolic re-programming has been observed in asthma as well as in response to rhinovirus infection. Here we aim to identify metabolic pathways associated with rhinovirus infection in the asthma bronchial epithelium and how alterations of these can normalize immune tolerance and resistance. Findings from this study will contribute to a better understanding of the dysregulated immune response to infection in asthma and may provide novel targets for therapeutic interventions aimed at treating viral-induced asthma exacerbations.
StatusPågående
Gällande start-/slutdatum2024/01/012026/12/31

Finansiering

  • Hjärt-Lungfonden