β-Glucan restores tumor-educated dendritic cell maturation to enhance antitumor immune responses.

Yongling Ning, Dongqin Xu, Xiaohang Zhang, Yu Bai, Jun Ding, Tongbao Feng, Shizhong Wang, Ning Xu, Keqing Qian, Yong Wang, Chunjian Qi

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendritic cells (TEDCs) involved in the tolerance induction have attracted much attention recently. In this study, we investigated the effect of β-glucan on TEDCs and found that β-glucan treatment could promote the maturation and migration of TEDCs and that the suppressive function of TEDCs was significantly decreased. Treatment with β-glucan drastically decreased the levels of regulatory T (Treg) cells but increased the infiltration of macrophages, granulocytes and DCs in tumor masses, thus elicited Th1 differentiation and cytotoxic T-lymphocyte responses and led to a delay in tumor progression. These findings reveal that β-glucan can inhibit the regulatory function of TEDCs, therefore revealing a novel function for β-glucan in immunotherapy and suggesting its potential clinical benefit. β-Glucan directly abrogated tumor-educated dendritic cells-associated immune suppression, promoted Th1 differentiation and cytotoxic T-lymphocyte priming and improved antitumor responses. This article is protected by copyright. All rights reserved.
Originalspråkengelska
Sidor (från-till)2713-2723
TidskriftInternational Journal of Cancer
Volym138
Nummer11
Tidigt onlinedatum2016 jan. 16
DOI
StatusPublished - 2016

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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