40 Hz invisible spectral flicker and its potential use in Alzheimer's light therapy treatment

Marcus S. Carstensen, Johannes Lindén, N. Mai Nguyen, Henrik E. Hansen, Gustavo M. Feijóo Carrillo, Luna S. Hansen, Dennis D. Corell, Jes Broeng, Lance J. Kriegsfeld, Paul Michael Petersen

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingPeer review


Alzheimer's disease (AD) not only takes an emotional toll on the individual with the disease, their families, relatives, and caretakers, it also has immense socioeconomic consequences on the health care system and society. Moreover, the socioeconomic consequences are expected to increase significantly, thus reducing the social and economic cost of AD is of high importance. Recently, exposure to 40 Hz stroboscopic light therapy, for one hour a day, resulted in slowing the progression of AD in mice and has a considerable potential for treatment in humans. However, exposure to such stroboscopic light carries its own consequences being that it is difficult to implement in a patient's daily routine, irksome to use, and can cause visual discomfort which may result in a lack of patient adherence. Here, we demonstrate a novel technology based on controlling multiple single-color LEDs to produce white light where its spectral composition alternates at a given modulation frequency without visible flicker. We coin this technique as Invisible Spectral Flicker (ISF). We present 40 Hz invisible spectral flicker light as a potential alternative in reducing discomfort compared to 40 Hz stroboscopic light, whilst still entraining oscillations in various areas of the brain. Furthermore, we demonstrate a distinct way to generate a 40 Hz metameric light source with the presented color mixing scheme, and validate that the CIE 1931 (x, y) coordinates match for two different spectral power distributions. Finally, we illustrate the light characteristics of seven 40 Hz color fusion light sources and two 40 Hz stroboscopic light sources. The technology presented here will lead to new, and hopefully improved, designs of light therapy systems for the treatment of Alzheimer's and dementia.

Titel på värdpublikationMechanisms of Photobiomodulation Therapy XV
RedaktörerMichael R. Hamblin, James D. Carroll, Praveen Arany
Antal sidor12
ISBN (elektroniskt)9781510632059
StatusPublished - 2020 mars 11
Externt publiceradJa
EvenemangMechanisms of Photobiomodulation Therapy XV 2020 - San Francisco, USA
Varaktighet: 2020 feb. 1 → …


NamnProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (tryckt)1605-7422


KonferensMechanisms of Photobiomodulation Therapy XV 2020
OrtSan Francisco
Period2020/02/01 → …

Bibliografisk information

Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

Ämnesklassifikation (UKÄ)

  • Geriatrik


Utforska forskningsämnen för ”40 Hz invisible spectral flicker and its potential use in Alzheimer's light therapy treatment”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här