5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

Elisabeth Hansson, Per Simonsson, Christer Alling

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.
Originalspråkengelska
Sidor (från-till)1377-1382
TidskriftNeuropharmacology
Volym26
Utgåva9
DOI
StatusPublished - 1987

Ämnesklassifikation (UKÄ)

  • Farmakologi och toxikologi

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