A matrix-free algorithm for multiple wavelength fluorescence tomography

Athanasios D. Zacharopoulos, Pontus Svenmarker, Johan Axelsson, Martin Schweiger, Simon R. Arridge, Stefan Andersson-Engels

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

14 Citeringar (SciVal)
150 Nedladdningar (Pure)


In the recent years, there has been an increase in applications of non-contact diffusion optical tomography. Especially when the objective is the recovery of fluorescence targets. The non-contact acquisition systems with the use of a CCD-camera produce much denser sampled boundary data sets than fibre-based systems. When model-based reconstruction methods are used, that rely on the inversion of a derivative operator, the large number of measurements poses a challenge since the explicit formulation and storage of the Jacobian matrix could be in general not feasible. This problem is aggravated further in applications, where measurements at multiple wavelengths are used. We present a matrix-free model-based reconstruction method, that addresses the problems of large data sets and reduces the computational cost and memory requirements for the reconstruction. The idea behind the matrix-free method is that information about the Jacobian matrix could be available through matrix times vector products so that the creation and storage of big matrices can be avoided. We tested the method for multiple wavelength fluorescence tomography with simulated and experimental data from phantom experiments, and we found substantial benefits in computational times and memory requirements. (C) 2009 Optical Society of America
Sidor (från-till)3025-3035
TidskriftOptics Express
StatusPublished - 2009

Ämnesklassifikation (UKÄ)

  • Atom- och molekylfysik och optik


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