A multisubstrate deoxyribonucleoside kinase from plants.

Anders Ranegaard Clausen, Lenart Girandon, Wolfgang Knecht, Sabeen Survery, Erik Andreasson, Birgitte Munch-Petersen, Jure Piskur

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
Originalspråkengelska
Sidor (från-till)489-490
TidskriftNucleic acids symposium series
Nummer52
DOI
StatusPublished - 2008

Ämnesklassifikation (UKÄ)

  • Biologiska vetenskaper

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