Sammanfattning
Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
Originalspråk | engelska |
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Sidor (från-till) | 489-490 |
Tidskrift | Nucleic acids symposium series |
Nummer | 52 |
DOI | |
Status | Published - 2008 |
Ämnesklassifikation (UKÄ)
- Biologiska vetenskaper