A new heteropentanuclear complex containing the [Fe2                             IIIZn3                             II(μ-OH)3] structural motif as a model for purple acid phosphatases

Filipy Gobbo Maranha; Graciela Aparecida dos Santos Silva; Adailton J. Bortoluzzi; Ebbe Nordlander; Rosely A. Peralta; Ademir Neves

doi:10.1016/j.ica.2019.119280

A new heteropentanuclear complex containing the [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural motif as a model for purple acid phosphatases

Filipy Gobbo Maranha, Graciela Aparecida dos Santos Silva, Adailton J. Bortoluzzi, Ebbe Nordlander, Rosely A. Peralta, Ademir Neves

Kemisk fysik

Federal University of Santa Catarina

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural unit and the unsymmetrical ligand H₂L²-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [Fe^III(μ-OH)Zn^II(L²-et)] unit that is connected to a second dinuclear [Fe^III(μ-OH)Zn^II(L²-et)] unit through a hydroxo bridge while a third Zn^II ion is coordinated by the pendant 1,2-ethanediamine groups of H₂L²-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear Fe^IIIZn^II complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.

Originalspråk	engelska
Artikelnummer	119280
Tidskrift	Inorganica Chimica Acta
DOI	https://doi.org/10.1016/j.ica.2019.119280
Status	Published - 2019 nov. 13

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Oorganisk kemi

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10.1016/j.ica.2019.119280

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Maranha, F. G., dos Santos Silva, G. A., Bortoluzzi, A. J., Nordlander, E., Peralta, R. A., & Neves, A. (2019). A new heteropentanuclear complex containing the [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural motif as a model for purple acid phosphatases. Inorganica Chimica Acta, [119280]. https://doi.org/10.1016/j.ica.2019.119280

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title = "A new heteropentanuclear complex containing the [Fe2 IIIZn3 II(μ-OH)3] structural motif as a model for purple acid phosphatases",

abstract = "Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.",

keywords = "Diesterase, Hydrolase, Pentanuclear complex",

author = "Maranha, {Filipy Gobbo} and {dos Santos Silva}, {Graciela Aparecida} and Bortoluzzi, {Adailton J.} and Ebbe Nordlander and Peralta, {Rosely A.} and Ademir Neves",

year = "2019",

month = nov,

day = "13",

doi = "10.1016/j.ica.2019.119280",

language = "English",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier",

}

A new heteropentanuclear complex containing the [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural motif as a model for purple acid phosphatases. / Maranha, Filipy Gobbo; dos Santos Silva, Graciela Aparecida; Bortoluzzi, Adailton J. et al.

I: Inorganica Chimica Acta, 13.11.2019.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

TY - JOUR

T1 - A new heteropentanuclear complex containing the [Fe2 IIIZn3 II(μ-OH)3] structural motif as a model for purple acid phosphatases

AU - Maranha, Filipy Gobbo

AU - dos Santos Silva, Graciela Aparecida

AU - Bortoluzzi, Adailton J.

AU - Nordlander, Ebbe

AU - Peralta, Rosely A.

AU - Neves, Ademir

PY - 2019/11/13

Y1 - 2019/11/13

N2 - Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.

AB - Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.

KW - Diesterase

KW - Hydrolase

KW - Pentanuclear complex

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U2 - 10.1016/j.ica.2019.119280

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JO - Inorganica Chimica Acta

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