A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens

Åsa Hellberg; Emma Pesjak; Jessica Karlsson; Jill R. Storry

doi:10.1111/trf.13679

A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens

Åsa Hellberg, Emma Pesjak, Jessica Karlsson, Jill R. Storry

Avdelningen för hematologi och klinisk immunologi

Region Skåne

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

205 Nedladdningar (Pure)

Sammanfattning

We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.

Originalspråk	engelska
Sidor (från-till)	2391-2392
Antal sidor	2
Tidskrift	Transfusion
Volym	56
Nummer	9
DOI	https://doi.org/10.1111/trf.13679
Status	Published - 2016 sep. 1

Ämnesklassifikation (UKÄ)

Hematologi

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10.1111/trf.13679

13581132Accepterat manuskript från författare, 409 KB

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title = "A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens",

abstract = "We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.",

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AB - We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.

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A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens

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Ämnesklassifikation (UKÄ)

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