TY - JOUR
T1 - A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia
AU - Lazarevic, Vladimir Lj
AU - Tomin, Dragica
AU - Jankovic, Gradimir M
AU - Antic, Darko
AU - Dencic, Marija
AU - Gotic, Mirjana
AU - Boskovic, Darinka
PY - 2004/1/1
Y1 - 2004/1/1
N2 - A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
AB - A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
KW - Aged
KW - Chromosomes, Human, Pair 17
KW - Chromosomes, Human, Pair 2
KW - Humans
KW - Leukemia, Myeloid, Acute
KW - Male
KW - Thrombocythemia, Essential
KW - Translocation, Genetic
UR - https://www.scopus.com/pages/publications/0347511684
U2 - 10.1016/S0165-4608(03)00215-2
DO - 10.1016/S0165-4608(03)00215-2
M3 - Article
C2 - 14697645
SN - 0165-4608
VL - 148
SP - 77
EP - 79
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -