A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes

Theresia M. Westers; Leonie Saft; Vincent H.J. van der Velden; Jeroen G. te Marvelde; Alan Dunlop; Robin Ireland; Peter Valent; Anna Porwit; Marie C. Béné; Arjan A. van de Loosdrecht

doi:10.1002/cyto.b.22061

A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes

Theresia M. Westers, Leonie Saft, Vincent H.J. van der Velden, Jeroen G. te Marvelde, Alan Dunlop, Robin Ireland, Peter Valent, Anna Porwit, Marie C. Béné, Arjan A. van de Loosdrecht

Patologi, Lund

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.

Originalspråk	engelska
Sidor (från-till)	87-97
Tidskrift	Cytometry Part B - Clinical Cytometry
Volym	104
Nummer	1
Tidigt onlinedatum	2022
DOI	https://doi.org/10.1002/cyto.b.22061
Status	Published - 2023

Ämnesklassifikation (UKÄ)

Hematologi

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10.1002/cyto.b.22061

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Westers, T. M., Saft, L., van der Velden, V. H. J., te Marvelde, J. G., Dunlop, A., Ireland, R., Valent, P., Porwit, A., Béné, M. C., & van de Loosdrecht, A. A. (2023). A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes. Cytometry Part B - Clinical Cytometry, 104(1), 87-97. https://doi.org/10.1002/cyto.b.22061

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title = "A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes",

abstract = "Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically {\textquoteleft}difficult{\textquoteright} cases.",

keywords = "cytopenia, dysplasia, flow cytometry, integrated diagnostics, MDS",

author = "Westers, {Theresia M.} and Leonie Saft and {van der Velden}, {Vincent H.J.} and {te Marvelde}, {Jeroen G.} and Alan Dunlop and Robin Ireland and Peter Valent and Anna Porwit and B{\'e}n{\'e}, {Marie C.} and {van de Loosdrecht}, {Arjan A.}",

year = "2023",

doi = "10.1002/cyto.b.22061",

language = "English",

volume = "104",

pages = "87--97",

journal = "Cytometry Part B - Clinical Cytometry",

issn = "1552-4949",

publisher = "Wiley-Liss Inc.",

number = "1",

}

Westers, TM, Saft, L, van der Velden, VHJ, te Marvelde, JG, Dunlop, A, Ireland, R, Valent, P, Porwit, A, Béné, MC & van de Loosdrecht, AA 2023, 'A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes', Cytometry Part B - Clinical Cytometry, vol. 104, nr. 1, s. 87-97. https://doi.org/10.1002/cyto.b.22061

TY - JOUR

T1 - A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes

AU - Westers, Theresia M.

AU - Saft, Leonie

AU - van der Velden, Vincent H.J.

AU - te Marvelde, Jeroen G.

AU - Dunlop, Alan

AU - Ireland, Robin

AU - Valent, Peter

AU - Porwit, Anna

AU - Béné, Marie C.

AU - van de Loosdrecht, Arjan A.

PY - 2023

Y1 - 2023

N2 - Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.

AB - Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically ‘difficult’ cases.

KW - cytopenia

KW - dysplasia

KW - flow cytometry

KW - integrated diagnostics

KW - MDS

U2 - 10.1002/cyto.b.22061

DO - 10.1002/cyto.b.22061

M3 - Article

C2 - 35179296

AN - SCOPUS:85124725693

SN - 1552-4949

VL - 104

SP - 87

EP - 97

JO - Cytometry Part B - Clinical Cytometry

JF - Cytometry Part B - Clinical Cytometry

IS - 1

ER -

A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes

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