A short history of chromosome rearrangements and gene fusions in cancer

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The molecular characterization of recurrent chromosome aberrations in the early 1980s laid the foundation for gene fusion detection in cancer. This approach remained the unrivalled method to identify fusion genes for a quarter of a century and led to the detection of more than 700 neoplasia-associated fusion genes. The advancement of deep sequencing in the mid-2000s revolutionized the search for cytogenetically undetectable fusions, and such studies have dramatically changed the gene fusion landscape. A myriad of new gene fusions-more than 1,300-the great majority involving previously unsuspected genes, have been identified by sequencing-based analyses during the past 10 years.

Titel på värdpublikationChromosomal Translocations and Genome Rearrangements in Cancer
RedaktörerJ D Rowley, M M Le Beau, T H Rabbitts
FörlagSpringer International Publishing
Antal sidor9
ISBN (elektroniskt)9783319199832
ISBN (tryckt)9783319199825
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Medicinsk genetik


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