A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

Kristian Soltesz, Klaske van Heusden, Martin Hast, J. Mark Ansermino, Guy A. Dumont

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingPeer review

248 Nedladdningar (Pure)


This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.
Titel på värdpublikationProceedings of the 2016 American Control Conference
FörlagIEEE - Institute of Electrical and Electronics Engineers Inc.
ISBN (elektroniskt)978-1-4673-8682-1
StatusPublished - 2016
EvenemangAmerican Control Conference, 2016 - Boston, USA
Varaktighet: 2016 juli 62016 juli 8


KonferensAmerican Control Conference, 2016
Förkortad titelACC 2016

Ämnesklassifikation (UKÄ)

  • Annan medicinteknik
  • Reglerteknik


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