A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

Heidi Marjonen; Minttu Marttila; Teemu Paajanen; Marleena Vornanen; Minna Brunfeldt; Anni Joensuu; Otto Halmesvaara; Kimmo Aro; Mervi Alanne-Kinnunen; Pekka Jousilahti; Katja Borodulin; Seppo Koskinen; Tiinamaija Tuomi; Pirjo Ilanne-Parikka; Jaana Lindström; Merja K. Laine; Kirsi Auro; Helena Kääriäinen; Markus Perola; Kati Kristiansson

doi:10.3389/fgene.2021.763159

A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

Heidi Marjonen, Minttu Marttila, Teemu Paajanen, Marleena Vornanen, Minna Brunfeldt, Anni Joensuu, Otto Halmesvaara, Kimmo Aro, Mervi Alanne-Kinnunen, Pekka Jousilahti, Katja Borodulin, Seppo Koskinen, Tiinamaija Tuomi, Pirjo Ilanne-Parikka, Jaana Lindström, Merja K. Laine, Kirsi Auro, Helena Kääriäinen, Markus Perola, Kati Kristiansson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

Originalspråk	engelska
Artikelnummer	763159
Tidskrift	Frontiers in Genetics
Volym	12
DOI	https://doi.org/10.3389/fgene.2021.763159
Status	Published - 2021 okt. 29

Bibliografisk information

Publisher Copyright:
Copyright © 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindström, Laine, Auro, Kääriäinen, Perola and Kristiansson.

Ämnesklassifikation (UKÄ)

Endokrinologi och diabetes

FN:s Globala mål

Denna forskningsoutput relaterar till följande Globala mål

Tillgång till dokument

10.3389/fgene.2021.763159

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Marjonen, H., Marttila, M., Paajanen, T., Vornanen, M., Brunfeldt, M., Joensuu, A., Halmesvaara, O., Aro, K., Alanne-Kinnunen, M., Jousilahti, P., Borodulin, K., Koskinen, S., Tuomi, T., Ilanne-Parikka, P., Lindström, J., Laine, M. K., Auro, K., Kääriäinen, H., Perola, M., & Kristiansson, K. (2021). A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study. Frontiers in Genetics, 12, Artikel 763159. https://doi.org/10.3389/fgene.2021.763159

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abstract = "We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person{\textquoteright}s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.",

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author = "Heidi Marjonen and Minttu Marttila and Teemu Paajanen and Marleena Vornanen and Minna Brunfeldt and Anni Joensuu and Otto Halmesvaara and Kimmo Aro and Mervi Alanne-Kinnunen and Pekka Jousilahti and Katja Borodulin and Seppo Koskinen and Tiinamaija Tuomi and Pirjo Ilanne-Parikka and Jaana Lindstr{\"o}m and Laine, {Merja K.} and Kirsi Auro and Helena K{\"a}{\"a}ri{\"a}inen and Markus Perola and Kati Kristiansson",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindstr{\"o}m, Laine, Auro, K{\"a}{\"a}ri{\"a}inen, Perola and Kristiansson.",

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month = oct,

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Marjonen, H, Marttila, M, Paajanen, T, Vornanen, M, Brunfeldt, M, Joensuu, A, Halmesvaara, O, Aro, K, Alanne-Kinnunen, M, Jousilahti, P, Borodulin, K, Koskinen, S, Tuomi, T, Ilanne-Parikka, P, Lindström, J, Laine, MK, Auro, K, Kääriäinen, H, Perola, M & Kristiansson, K 2021, 'A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study', Frontiers in Genetics, vol. 12, 763159. https://doi.org/10.3389/fgene.2021.763159

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AU - Marjonen, Heidi

AU - Marttila, Minttu

AU - Paajanen, Teemu

AU - Vornanen, Marleena

AU - Brunfeldt, Minna

AU - Joensuu, Anni

AU - Halmesvaara, Otto

AU - Aro, Kimmo

AU - Alanne-Kinnunen, Mervi

AU - Jousilahti, Pekka

AU - Borodulin, Katja

AU - Koskinen, Seppo

AU - Tuomi, Tiinamaija

AU - Ilanne-Parikka, Pirjo

AU - Lindström, Jaana

AU - Laine, Merja K.

AU - Auro, Kirsi

AU - Kääriäinen, Helena

AU - Perola, Markus

AU - Kristiansson, Kati

N1 - Publisher Copyright: Copyright © 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindström, Laine, Auro, Kääriäinen, Perola and Kristiansson.

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N2 - We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

AB - We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

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KW - finhealth 2017 study

KW - P5 study

KW - polygenic risk sore

KW - precision population health

KW - type 2 diabetes

KW - venous thromboembolism

KW - web portal

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DO - 10.3389/fgene.2021.763159

M3 - Article

C2 - 34777479

AN - SCOPUS:85119034268

SN - 1664-8021

VL - 12

JO - Frontiers in Genetics

JF - Frontiers in Genetics

M1 - 763159

ER -

A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

Sammanfattning

Bibliografisk information

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

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