Accuracy of the quantification of organ activity from planar gamma camera images

Kristina Norrgren, SL Svegborn, Johan Areberg, Sören Mattsson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

29 Citeringar (SciVal)

Sammanfattning

The accuracy in determination of organ activity of Tc-99m was investigated, with activity estimated from gamma camera images of phantoms, using the, conjugate view method. The accuracy depends on several parameters such as the choice of background correction method, the accuracy in determination of the effective attenuation coefficient and the thickness of the body and organs and on the determination of the gamma camera sensitivity. The background correction method has a major influence on the quantification of the activity. Methods which take the volume of the source organ into consideration are recommended The discrepancy in the determined organ activity varied between an underestimation of 26% and an overestimation of 16% in the MIRD phantom, depending on which organ was studied and on the correction method used To correct for absorption and scattering, an effective attenuation coefficient was used. A theoretical analysis showed that a change in the effective attenuation coefficient of 0.01 cm(-1) resulted in a 15% change in the calculated activity. Also the thickness of the body and the organ of interest influences the calculated activity. A 2 cm deviation in the body thickness causes a deviation of approximately 10% in the calculated activity. The quantification is improved if the attenuation coefficient is determined by transmission measurements.
Originalspråkengelska
Sidor (från-till)125-131
TidskriftCancer Biotherapy & Radiopharmaceuticals
Volym18
Utgåva1
DOI
StatusPublished - 2003

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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