Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

Oddrun Elise Olsen; Karin Fahl Wader; Hanne Hella; Anne Kærsgaard Mylin; Ingemar Turesson; Ingerid Nesthus; Anders Waage; Anders Sundan; Toril Holien

doi:10.1186/s12964-015-0104-z

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

Oddrun Elise Olsen, Karin Fahl Wader, Hanne Hella, Anne Kærsgaard Mylin, Ingemar Turesson, Ingerid Nesthus, Anders Waage, Anders Sundan, Toril Holien

Avdelningen för hematologi och klinisk immunologi

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

206 Nedladdningar (Pure)

Sammanfattning

Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.

Originalspråk	engelska
Artikelnummer	27
Tidskrift	Cell Communication and Signaling
Volym	13
Nummer	1
DOI	https://doi.org/10.1186/s12964-015-0104-z
Status	Published - 2015

Ämnesklassifikation (UKÄ)

Hematologi

FN:s Globala mål

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10.1186/s12964-015-0104-z

BMC_Olsen_et_al

http://www.ncbi.nlm.nih.gov/pubmed/26047946?dopt=Abstract

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title = "Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.",

abstract = "Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.",

author = "Olsen, {Oddrun Elise} and Wader, {Karin Fahl} and Hanne Hella and Mylin, {Anne K{\ae}rsgaard} and Ingemar Turesson and Ingerid Nesthus and Anders Waage and Anders Sundan and Toril Holien",

year = "2015",

doi = "10.1186/s12964-015-0104-z",

language = "English",

volume = "13",

journal = "Cell Communication and Signaling",

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T1 - Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

AU - Olsen, Oddrun Elise

AU - Wader, Karin Fahl

AU - Hella, Hanne

AU - Mylin, Anne Kærsgaard

AU - Turesson, Ingemar

AU - Nesthus, Ingerid

AU - Waage, Anders

AU - Sundan, Anders

AU - Holien, Toril

PY - 2015

Y1 - 2015

N2 - Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.

AB - Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.

U2 - 10.1186/s12964-015-0104-z

DO - 10.1186/s12964-015-0104-z

M3 - Article

C2 - 26047946

SN - 1478-811X

VL - 13

JO - Cell Communication and Signaling

JF - Cell Communication and Signaling

IS - 1

M1 - 27

ER -

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

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