TY - JOUR
T1 - Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema
AU - Aaltonen, H. Laura
AU - Petersson Sjögren, Madeleine
AU - Jakobsson, Jonas K.F.
AU - Nicklasson, Hanna
AU - Diaz, Sandra
AU - Sánchez Montiel, Francisco
AU - Zackrisson, Sophia
AU - Ideböhn, Veronica
AU - Engström, Gunnar
AU - Löndahl, Jakob
AU - Wollmer, Per
PY - 2021
Y1 - 2021
N2 - Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.
AB - Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.
KW - emphysema
KW - exhaled airway markers
KW - imaging/CT MRI
KW - respiratory measurement
U2 - 10.1136/thoraxjnl-2020-214523
DO - 10.1136/thoraxjnl-2020-214523
M3 - Article
C2 - 33859054
AN - SCOPUS:85104459368
SN - 0040-6376
VL - 76
SP - 1040
EP - 1043
JO - Thorax
JF - Thorax
IS - 10
ER -