Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

Susan Peters, Valentina Gallo, Paolo Vineis, Lefkos T. Middleton, Lars Forsgren, Carlotta Sacerdote, Sabina Sieri, Andreas Kyrozis, María Dolores Chirlaque, Raul Zamora-Ros, Oskar Hansson, Jesper Petersson, Verena Katzke, Tilman Kühn, Olatz Mokoroa, Giovanna Masala, Eva Ardanaz, Salvatore Panico, Manuela M. Bergmann, Timothy J. KeyElisabete Weiderpass, Pietro Ferrari, Roel Vermeulen

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

11 Citeringar (SciVal)

Sammanfattning

Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.

Originalspråkengelska
Sidor (från-till)1258-1263
Antal sidor6
TidskriftMovement Disorders
Volym35
Nummer7
Tidigt onlinedatum2020 maj 1
DOI
StatusPublished - 2020 juli

Ämnesklassifikation (UKÄ)

  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
  • Neurologi

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