Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN-trial

Gabriel Adrian; Maria Gebre-Medhin; Elisabeth Kjellén; Elinore Wieslander; Björn Zackrisson; Per Nilsson

doi:10.1002/hed.26142

Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN-trial

Gabriel Adrian, Maria Gebre-Medhin, Elisabeth Kjellén, Elinore Wieslander, Björn Zackrisson, Per Nilsson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.

METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.

RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors.

CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.

Originalspråk	engelska
Sidor (från-till)	2099-2105
Antal sidor	7
Tidskrift	Head and Neck
Volym	42
Nummer	8
Tidigt onlinedatum	2020 mars 20
DOI	https://doi.org/10.1002/hed.26142
Status	Published - 2020 aug.

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Cancer och onkologi
Radiologi och bildbehandling

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10.1002/hed.26142Licens: CC BY

1 Doktorsavhandling (sammanläggning)

Altering Radiation Response with Time, Volume and Fractionation
Adrian, G., 2021, Lund: Lund University, Faculty of Medicine. 93 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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title = "Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN-trial",

abstract = "BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors.CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.",

author = "Gabriel Adrian and Maria Gebre-Medhin and Elisabeth Kjell{\'e}n and Elinore Wieslander and Bj{\"o}rn Zackrisson and Per Nilsson",

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year = "2020",

month = aug,

doi = "10.1002/hed.26142",

language = "English",

volume = "42",

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TY - JOUR

T1 - Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer

T2 - Subgroup analysis of ARTSCAN-trial

AU - Adrian, Gabriel

AU - Gebre-Medhin, Maria

AU - Kjellén, Elisabeth

AU - Wieslander, Elinore

AU - Zackrisson, Björn

AU - Nilsson, Per

PY - 2020/8

Y1 - 2020/8

N2 - BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors.CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.

AB - BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors.CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.

U2 - 10.1002/hed.26142

DO - 10.1002/hed.26142

M3 - Article

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VL - 42

SP - 2099

EP - 2105

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 8

ER -

Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer: Subgroup analysis of ARTSCAN-trial

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Altering Radiation Response with Time, Volume and Fractionation

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