Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.

Johan S Nilsson; Sissela Broos; Takami Akagi; Mitsuru Akashi; Ann Hermansson; Per Cayé-Thomasen; Malin Lindstedt; Lennart Greiff

doi:10.3109/00016489.2014.918278

Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.

Johan S Nilsson, Sissela Broos, Takami Akagi, Mitsuru Akashi, Ann Hermansson, Per Cayé-Thomasen, Malin Lindstedt, Lennart Greiff

Öron-, näs- och halssjukdomar, Lund

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.

Originalspråk	engelska
Sidor (från-till)	1034-1041
Tidskrift	Acta Oto-Laryngologica
Volym	134
Nummer	10
DOI	https://doi.org/10.3109/00016489.2014.918278
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Oto-rhino-laryngologi

FN:s Globala mål

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10.3109/00016489.2014.918278

http://www.ncbi.nlm.nih.gov/pubmed/25220726?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Dissecting nasopharyngeal cancer. Studies on prerequisites for antigen-specific active immunotherapy.
Nilsson, J., 2020, Lund: Lund University, Faculty of Medicine. 92 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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title = "Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.",

abstract = "Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.",

author = "Nilsson, {Johan S} and Sissela Broos and Takami Akagi and Mitsuru Akashi and Ann Hermansson and Per Cay{\'e}-Thomasen and Malin Lindstedt and Lennart Greiff",

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doi = "10.3109/00016489.2014.918278",

language = "English",

volume = "134",

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journal = "Acta Oto-Laryngologica",

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T1 - Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.

AU - Nilsson, Johan S

AU - Broos, Sissela

AU - Akagi, Takami

AU - Akashi, Mitsuru

AU - Hermansson, Ann

AU - Cayé-Thomasen, Per

AU - Lindstedt, Malin

AU - Greiff, Lennart

PY - 2014

Y1 - 2014

N2 - Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.

AB - Abstract Conclusion: Amphiphilic biodegradable nanoparticles (NPs) composed of poly(γ-glutamic acid) conjugated with L-phenylalanine ethylester (γ-PGA-Phe NPs) applied on the rat middle ear mucosa produce an inflammatory type 1 response. The observation is of relevance for the use of γ-PGA-Phe NPs as a concomitant antigen delivery system and adjuvant measure in the context of vaccinations.

U2 - 10.3109/00016489.2014.918278

DO - 10.3109/00016489.2014.918278

M3 - Article

C2 - 25220726

SN - 1651-2251

VL - 134

SP - 1034

EP - 1041

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 10

ER -

Amphiphilic γ-PGA nanoparticles administered on rat middle ear mucosa produce adjuvant-like immunostimulation in vivo.

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

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Forskningsoutput

Dissecting nasopharyngeal cancer. Studies on prerequisites for antigen-specific active immunotherapy.

Citera det här