An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

Martin Wahlestedt, Gudmundur Norddahl, Gerd Sten, Amol Ugale, Mary-Ann Micha Frisk, Ragnar Mattsson, Tomas Deierborg, Mikael Sigvardsson, David Bryder

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

376 Nedladdningar (Pure)

Sammanfattning

Key points Hematopoietic stem cell aging associate with stable transcriptional alterations that persist through transplantation.Somatic cell reprogramming of aged hematopoietic stem and progenitor cells reverses functional defects associated with hematopoietic aging.
Originalspråkengelska
Sidor (från-till)4257-4264
TidskriftBlood
Volym121
Nummer21
DOI
StatusPublished - 2013

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Stem Cell Center (013041110), Reproductive Immunology (013212062), Stem Cell Aging (013212073), BMC Biomedical Centre (0130322000), Neuroinflammation (013210006)

Ämnesklassifikation (UKÄ)

  • Hematologi

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