An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Alberto Pagani; Federica Pollastro; Silvia Spera; Mauro Ballero; Olov Sterner; Giovanni Appendino

An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Alberto Pagani, Federica Pollastro, Silvia Spera, Mauro Ballero, Olov Sterner, Giovanni Appendino

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Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

Originalspråk	engelska
Sidor (från-till)	637-642
Tidskrift	Natural Product Communications
Volym	2
Nummer	6
Status	Published - 2007

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

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title = "An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin",

abstract = "A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32\% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.",

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author = "Alberto Pagani and Federica Pollastro and Silvia Spera and Mauro Ballero and Olov Sterner and Giovanni Appendino",

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T1 - An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

AU - Pagani, Alberto

AU - Pollastro, Federica

AU - Spera, Silvia

AU - Ballero, Mauro

AU - Sterner, Olov

AU - Appendino, Giovanni

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2007

Y1 - 2007

N2 - A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

AB - A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

KW - SERCA

KW - Thapsia garganica

KW - neohelmanthicin D

KW - thapsivillosin J

KW - thapsigargin

KW - thapsigargicin

UR - https://www.scopus.com/pages/publications/78549265885

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JO - Natural Product Communications

JF - Natural Product Communications

IS - 6

ER -

An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

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Bibliografisk information

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