An improved probing controller for substrate feeding in fed-batch culteres of E. coli: simulations and experiments

Mats Åkesson, Per Hagander, Jan Peter Axelsson

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Sammanfattning

A strategy for feedback control of the glucose feed rate in cultivations of E.coli is discussed. By making probing pulses in the feedrate it is possible to detect and avoid undesirable by-productformation using a standard dissolved oxygen sensor. The feasibility of an improved and simplified probing algorithm is demonstrated by simulations as well as laboratory-scale experiments.
Originalspråkengelska
Titel på gästpublikationComputer Applications in Biotechnology 2001
FörlagElsevier
Sidor213-218
ISBN (tryckt)0080436811
StatusPublished - 2002
Evenemang8th IFAC International Conference on Computer Applications in Biotechnology (CAB8) - Quebeq City, Kanada
Varaktighet: 2001 jun 242001 jun 27

Konferens

Konferens8th IFAC International Conference on Computer Applications in Biotechnology (CAB8)
Land/TerritoriumKanada
OrtQuebeq City
Period2001/06/242001/06/27

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