An Integrated Thermal Sensor Array For Multianalyte determination demonstrated With Glucose, Urea And Penicillin

Bin Xie; Bengt Danielsson

doi:10.1109/SENSOR.1995.717264

An Integrated Thermal Sensor Array For Multianalyte determination demonstrated With Glucose, Urea And Penicillin

Bin Xie, Bengt Danielsson

Tillämpad biokemi

Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Konferenspaper i proceeding › Peer review

Sammanfattning

An integrated thermal biosensor array was designed and fabricated for the simultaneous determination of glucose, urea and penicillin. The sensor contains ten thin-film thermistors which were fabricated on quartz chip by micromachining and semiconductor technologies. This sensor allows to determine maximum five different analytes nearly simultaneously by serially dividing the single microchannel into five distinct detection regions. Each of the regions contains one immobilized enzyme and a pair of thermistors for differential measurement of the thermal signal corresponding to the enzyme reaction. Using this device, glucose, urea and penicillin mixed samples at different concentrations were determined. The linear ranges of at least 25 mM for urea and penicillin, and up to 20 mM for glucose were obtained using a sample volume of 20 μ/l.

Originalspråk	engelska
Titel på värdpublikation	Proceedings of the International Solid-State Sensors and Actuators Conference - TRANSDUCERS '95
Förlag	IEEE Press
Sidor	501-503
Antal sidor	3
Volym	1
ISBN (tryckt)	91-630-3473-5
DOI	https://doi.org/10.1109/SENSOR.1995.717264
Status	Published - 1995

Ämnesklassifikation (UKÄ)

Analytisk kemi

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10.1109/SENSOR.1995.717264

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title = "An Integrated Thermal Sensor Array For Multianalyte determination demonstrated With Glucose, Urea And Penicillin",

abstract = "An integrated thermal biosensor array was designed and fabricated for the simultaneous determination of glucose, urea and penicillin. The sensor contains ten thin-film thermistors which were fabricated on quartz chip by micromachining and semiconductor technologies. This sensor allows to determine maximum five different analytes nearly simultaneously by serially dividing the single microchannel into five distinct detection regions. Each of the regions contains one immobilized enzyme and a pair of thermistors for differential measurement of the thermal signal corresponding to the enzyme reaction. Using this device, glucose, urea and penicillin mixed samples at different concentrations were determined. The linear ranges of at least 25 mM for urea and penicillin, and up to 20 mM for glucose were obtained using a sample volume of 20 μ/l.",

author = "Bin Xie and Bengt Danielsson",

year = "1995",

doi = "10.1109/SENSOR.1995.717264",

language = "English",

isbn = "91-630-3473-5",

volume = "1",

pages = "501--503",

booktitle = "Proceedings of the International Solid-State Sensors and Actuators Conference - TRANSDUCERS '95",

publisher = "IEEE Press",

}

An Integrated Thermal Sensor Array For Multianalyte determination demonstrated With Glucose, Urea And Penicillin. / Xie, Bin; Danielsson, Bengt.
Proceedings of the International Solid-State Sensors and Actuators Conference - TRANSDUCERS '95. Vol. 1 IEEE Press, 1995. s. 501-503.

Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Konferenspaper i proceeding › Peer review

TY - GEN

T1 - An Integrated Thermal Sensor Array For Multianalyte determination demonstrated With Glucose, Urea And Penicillin

AU - Xie, Bin

AU - Danielsson, Bengt

PY - 1995

Y1 - 1995

N2 - An integrated thermal biosensor array was designed and fabricated for the simultaneous determination of glucose, urea and penicillin. The sensor contains ten thin-film thermistors which were fabricated on quartz chip by micromachining and semiconductor technologies. This sensor allows to determine maximum five different analytes nearly simultaneously by serially dividing the single microchannel into five distinct detection regions. Each of the regions contains one immobilized enzyme and a pair of thermistors for differential measurement of the thermal signal corresponding to the enzyme reaction. Using this device, glucose, urea and penicillin mixed samples at different concentrations were determined. The linear ranges of at least 25 mM for urea and penicillin, and up to 20 mM for glucose were obtained using a sample volume of 20 μ/l.

AB - An integrated thermal biosensor array was designed and fabricated for the simultaneous determination of glucose, urea and penicillin. The sensor contains ten thin-film thermistors which were fabricated on quartz chip by micromachining and semiconductor technologies. This sensor allows to determine maximum five different analytes nearly simultaneously by serially dividing the single microchannel into five distinct detection regions. Each of the regions contains one immobilized enzyme and a pair of thermistors for differential measurement of the thermal signal corresponding to the enzyme reaction. Using this device, glucose, urea and penicillin mixed samples at different concentrations were determined. The linear ranges of at least 25 mM for urea and penicillin, and up to 20 mM for glucose were obtained using a sample volume of 20 μ/l.

U2 - 10.1109/SENSOR.1995.717264

DO - 10.1109/SENSOR.1995.717264

M3 - Paper in conference proceeding

SN - 91-630-3473-5

VL - 1

SP - 501

EP - 503

BT - Proceedings of the International Solid-State Sensors and Actuators Conference - TRANSDUCERS '95

PB - IEEE Press

ER -

An Integrated Thermal Sensor Array For Multianalyte determination demonstrated With Glucose, Urea And Penicillin

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