An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves

Anna Fornell, Mathias Ohlin, Fabio Garofalo, Johan Nilsson, Maria Tenje

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

Originalspråkengelska
Artikelnummer031101
TidskriftBiomicrofluidics
Volym11
Nummer3
DOI
StatusPublished - 2017 maj 1

Ämnesklassifikation (UKÄ)

  • Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

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