Analysis of anti-C1q autoantibodies by western blot

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Sammanfattning

Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of complement, C1q. These different binding specificities can be detected by Western blot analysis of the autoantibodies under reducing conditions. Results may help clinicians to differentiate between SLE and HUVS.

Originalspråkengelska
Titel på värdpublikationMethods in Molecular Biology
FörlagHumana Press
Sidor183-189
Antal sidor7
DOI
StatusPublished - 2019

Publikationsserier

NamnMethods in Molecular Biology
Volym1901
ISSN (tryckt)1064-3745

Ämnesklassifikation (UKÄ)

  • Reumatologi och inflammation

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