Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

Roland Schmitt, Gunnar Lindahl, Diana Karpman

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

5 Citeringar (SciVal)

Sammanfattning

Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.
Originalspråkengelska
Sidor (från-till)3434-3436
TidskriftNephrology Dialysis Transplantation
Volym25
Utgåva10
DOI
StatusPublished - 2010

Ämnesklassifikation (UKÄ)

  • Urologi och njurmedicin

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