Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

Ivan Limachi, Claudia Condo, Camila Palma, Nelida Nina, Efrain Salamanca, Juan C. Ticona, Enrique Udaeta, Ninoska Flores, Alcides Serato, Natalio Marupa, Benigno Chao, Gladys Ibaguari, Constantino Nay, Soffie Manner, Olov Sterner, Alberto Giménez

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

2 Citeringar (SciVal)

Sammanfattning

A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

Originalspråkengelska
Sidor (från-till)55-58
Antal sidor4
TidskriftNatural Product Communications
Volym14
Utgåva1
DOI
StatusPublished - 2019

Ämnesklassifikation (UKÄ)

  • Farmaceutisk vetenskap
  • Mikrobiologi

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