ApoM: gene regulation and effects on HDL metabolism

Lars B. Nielsen, Christina Christoffersen, Josefin Ahnström, Björn Dahlbäck

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

29 Citeringar (SciVal)

Sammanfattning

The recently discovered apolipoprotein M (apoM) is a plasma protein of the lipocalin family associated with the lipoproteins (mainly high-density lipoproteins, or HDLs). Expression of the apoM gene in the liver is regulated by transcription factors that control key steps in hepatic lipid and glucose metabolism. Although the concentration of plasma apoM correlates with that of cholesterol, apoM was not identified as a risk factor for cardiovascular disease in two prospective studies. In genetically modified mice, however, changes in plasma apoM concentration caused quantitative and qualitative changes in HDLs, and overexpression of the apoM gene reduced atherosclerosis. In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined.
Originalspråkengelska
Sidor (från-till)66-71
TidskriftTrends in Endocrinology and Metabolism
Volym20
Utgåva2
DOI
StatusPublished - 2009

Ämnesklassifikation (UKÄ)

  • Endokrinologi och diabetes

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