Sammanfattning

Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding.

Originalspråkengelska
Artikelnummer183795
TidskriftBiochimica et Biophysica Acta - Biomembranes
Volym1864
Nummer1
DOI
StatusPublished - 2022 feb. 1

Bibliografisk information

Publisher Copyright:
© 2021 The Authors

Ämnesklassifikation (UKÄ)

  • Biokemi och molekylärbiologi

Fingeravtryck

Utforska forskningsämnen för ”Aquaglyceroporins and orthodox aquaporins in human adipocytes”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här