Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds

Tahzeeb Fatima, Lennart T.H. Jacobsson, Silke Kern, Anna Zettergren, Kaj Blennow, Henrik Zetterberg, Lena Johansson, Mats Dehlin, Ingmar Skoog

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ42/Aβ40 ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ42 in males (β = 0.55 pg/mL, P =.04). There was a positive urate–APOE ε4 interaction (1.24 pg/mL, Pinteraction =.02) in relation to Aβ42 association. The positive urate and Aβ42 association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P =.01). Discussion: The positive association between urate and Aβ42 in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.

Originalspråkengelska
Artikelnummere12241
TidskriftAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volym13
Nummer1
DOI
StatusPublished - 2021

Ämnesklassifikation (UKÄ)

  • Neurologi

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